Arachidonic acid and lipoxinA4 attenuate streptozotocin-induced cytotoxicity to RIN5 F cells in vitro and type 1 and type 2 diabetes mellitus in vivo

Gundala, Naveen K.V.; Naidu, V.G.M.; Das, Undurti N.

doi:10.1016/j.nut.2016.10.004

Cited by 86 publications

(70 citation statements)

References 47 publications

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“…In a series of previous studies, we showed that oral feeding of oils rich in ω-3 EPA and DHA and ω-6 GLA and AA or pure FFAs (GLA, AA, EPA, and DHA) prevent apoptosis of insulin-secreting rat insulinoma (RIN5F) cells in vitro and alloxan-induced type 1 DM and STZ-induced type 1 and type 2 DM in experimental animals ( 15 – 18 , 137 , 420 ). This beneficial action of PUFAs against chemical-induced type 1 and type 2 DM is not abrogated by COX and LOX inhibitors, suggesting that fatty acids themselves are active and/or their anti-inflammatory LXs, resolvins, protectins, and maresins may have antidiabetic actions [see Figures 6 – 8 and Ref.…”

Section: Conclusion: Pufas and Their Metabolites In Dmmentioning

confidence: 99%

“…This beneficial action of PUFAs against chemical-induced type 1 and type 2 DM is not abrogated by COX and LOX inhibitors, suggesting that fatty acids themselves are active and/or their anti-inflammatory LXs, resolvins, protectins, and maresins may have antidiabetic actions [see Figures 6 – 8 and Ref. ( 15 – 18 , 137 , 420 )], while pro-inflammatory PGs, LTs, and TXs are ineffective ( 131 , 132 ). Our recent studies showed that fish oil (a rich source of EPA and DHA) altered the growth of Helicobacter, Clostridiales, Sphingomonadales, Firmicutes, Pseudomonas species, and several other bacteria ( 421 ).…”

Section: Conclusion: Pufas and Their Metabolites In Dmmentioning

confidence: 99%

“…It is interesting that AA and LXA4 prevented both alloxan-induced type 1 DM and type 1 and type 2 DM induced by STZ [see Figure 13 , results with LXA4 only are shown ( 137 , 420 )]. LXA4 treatment decreased plasma TNF-α level.…”

Section: Conclusion: Pufas and Their Metabolites In Dmmentioning

confidence: 99%

“…Expression of genes Pdx1 and IKB were increased while that of NF-kB was decreased in pancreatic tissue in LXA4-treated animals, suggesting that anti-inflammatory action is one of the mechanisms by which LXA4 can prevent type 2 DM. In addition, the expressions of lipocalin-2 and NF-kB were decreased, whereas that of IKB was enhanced in LXA4-treated animals in adipose tissue ( 420 ). It is worth noting that alloxan STZ and HFD inhibit the activity of both Δ 6 and Δ 5 desaturases and enhance concentrations of pro-inflammatory PGE2 and, thus, induce insulin resistance, the hallmark of obesity, type 2 DM and metabolic syndrome [unpublished data, see Figure 4 , and Ref.…”

Section: Conclusion: Pufas and Their Metabolites In Dmmentioning

confidence: 99%

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Is There a Role for Bioactive Lipids in the Pathobiology of Diabetes Mellitus?

Das¹

2017

Front. Endocrinol.

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Inflammation, decreased levels of circulating endothelial nitric oxide (eNO) and brain-derived neurotrophic factor (BDNF), altered activity of hypothalamic neurotransmitters (including serotonin and vagal tone) and gut hormones, increased concentrations of free radicals, and imbalance in the levels of bioactive lipids and their pro- and anti-inflammatory metabolites have been suggested to play a role in diabetes mellitus (DM). Type 1 diabetes mellitus (type 1 DM) is due to autoimmune destruction of pancreatic β cells because of enhanced production of IL-6 and tumor necrosis factor-α (TNF-α) and other pro-inflammatory cytokines released by immunocytes infiltrating the pancreas in response to unknown exogenous and endogenous toxin(s). On the other hand, type 2 DM is due to increased peripheral insulin resistance secondary to enhanced production of IL-6 and TNF-α in response to high-fat and/or calorie-rich diet (rich in saturated and trans fats). Type 2 DM is also associated with significant alterations in the production and action of hypothalamic neurotransmitters, eNO, BDNF, free radicals, gut hormones, and vagus nerve activity. Thus, type 1 DM is because of excess production of pro-inflammatory cytokines close to β cells, whereas type 2 DM is due to excess of pro-inflammatory cytokines in the systemic circulation. Hence, methods designed to suppress excess production of pro-inflammatory cytokines may form a new approach to prevent both type 1 and type 2 DM. Roux-en-Y gastric bypass and similar surgeries ameliorate type 2 DM, partly by restoring to normal: gut hormones, hypothalamic neurotransmitters, eNO, vagal activity, gut microbiota, bioactive lipids, BDNF production in the gut and hypothalamus, concentrations of cytokines and free radicals that results in resetting glucose-stimulated insulin production by pancreatic β cells. Our recent studies suggested that bioactive lipids, such as arachidonic acid, eicosapentaneoic acid, and docosahexaenoic acid (which are unsaturated fatty acids) and their anti-inflammatory metabolites: lipoxin A4, resolvins, protectins, and maresins, may have antidiabetic actions. These bioactive lipids have anti-inflammatory actions, enhance eNO, BDNF production, restore hypothalamic dysfunction, enhance vagal tone, modulate production and action of ghrelin, leptin and adiponectin, and influence gut microbiota that may explain their antidiabetic action. These pieces of evidence suggest that methods designed to selectively deliver bioactive lipids to pancreatic β cells, gut, liver, and muscle may prevent type 1 and type 2 DM.

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Section: Conclusion: Pufas and Their Metabolites In Dmmentioning

confidence: 99%

Section: Conclusion: Pufas and Their Metabolites In Dmmentioning

confidence: 99%

Section: Conclusion: Pufas and Their Metabolites In Dmmentioning

confidence: 99%

Section: Conclusion: Pufas and Their Metabolites In Dmmentioning

confidence: 99%

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Is There a Role for Bioactive Lipids in the Pathobiology of Diabetes Mellitus?

Das¹

2017

Front. Endocrinol.

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“…Gundala NKV Arachidonic acid and lipoxinA4 attenuate streptozotocin-induced cytotoxicity to RIN5 F cells in vitro and type 1 and type 2 diabetes mellitus in vivo Basic nutritional investigation 17 123…”

mentioning

confidence: 99%

The Journal of Cachexia, Sarcopenia and Muscle stays the front‐runner in geriatrics and gerontology

Anker

Coats

et al. 2019

J cachexia sarcopenia muscle

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This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. also looked at the top cited scientific papers ever published in the three journals (Tables 10-12) and found that on average, the top 10 papers in JCSM were cited 152 times, in Nutrition 670 times, and in JNHA 406 times-which is mainly due to the fact that Nutrition has been listed in Scopus 265 since 1987 and JNHA since 1997, while JCSM started only in 2010. So far, JCSM has published 563 papers, Nutrition 6198 papers, and JNHA 2396 papers. On average, JCSM has published 56 papers/year, Nutrition 188 papers/year, and JNHA 104 papers/year, which of course are major determinants of the respective journal's impact factor. This also underscores that all three journals have different approaches towards the number of papers published per year. We are grateful and look forward to more submissions of excellent research in the field of wasting and muscle disorders and are confident to maintain high quality in the Journal.

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Pyridoxine, essential fatty acids, and protection against doxorubicin‐induced cardiotoxicity

Das

2024

J Biochem & Molecular Tox

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Sun et al. [1] showed that vitamin B6 (pyridoxine) protects against doxorubicin-(DOX) induced cardiotoxicity by its antioxidant and antiapoptotic actions principally by decreasing NHE1 (Na + /H + exchanger) expression and thus, improved DOX-induced cardiotoxicity. I would like to suggest an alternative explanation for the interesting results obtained.Data sharing is not applicable to this article as no new data were created or analyzed in this study.

show abstract

Arachidonic acid and lipoxinA4 attenuate streptozotocin-induced cytotoxicity to RIN5 F cells in vitro and type 1 and type 2 diabetes mellitus in vivo

Cited by 86 publications

References 47 publications

Is There a Role for Bioactive Lipids in the Pathobiology of Diabetes Mellitus?

Is There a Role for Bioactive Lipids in the Pathobiology of Diabetes Mellitus?

The Journal of Cachexia, Sarcopenia and Muscle stays the front‐runner in geriatrics and gerontology

Pyridoxine, essential fatty acids, and protection against doxorubicin‐induced cardiotoxicity

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