Arachidonic acid improves aged rats' spatial cognition

Arachidonic Acid Supplementation Decreases P300 Latency and Increases P300 Amplitude of Event-Related Potentials in Healthy Elderly Men

“…As noted above, in animal studies, it has been reported that, with aging, spatial cognition and learning ability are decreased, as are ARA and DHA contents in cerebral phospholipids, and that recovery of these abilities can be obtained with the addition of ARA-and DHA-containing oils to feed [12][13][14]20] .…”

“…Similarly, in a study of ARA supplementation to aged rats with measurement of LTP in the CA1 subfield of the hippocampus, Kotani et al [13] found that in responding to tetanic stimulation, ARA-fed aged rats exhibited an increase in excitatory postsynaptic potential slope change that matched that in the young control rats. Moreover, ARA-fed aged rats exhibited better performance in Morris water maze training [14] .…”

Phospholipase A2 activation as a therapeutic approach for cognitive enhancement in early-stage Alzheimer disease

“…Animal studies have shown that long-term intake of dietary compounds enriched with AA preserves hippocampal synaptic plasticity and neuronal membrane fluidity and enhances spatial memory performance of aged rats. A significant correlation was observed between the behavioral performance and AA composition in hippocampal phospholipids (Kotani et al 2003;Okaichi et al 2005;Fukaya et al 2007). Additionally, long-term dietary supplementation with PtdCho enhanced spatial learning ability of aged mice Suzuki 2000a, b, 2002).…”

TRP channels, omega-3 fatty acids, and oxidative stress in neurodegeneration: from the cell membrane to intracellular cross-links

“…In aged rats, spatial memory and hippocampal long-term potentiation can be improved with dietary supplementation of arachidonic acid and the memory function of human subjects is significantly improved with PUFA supplementation (56)(57)(58). DHA is also essential for neural development and brain function (59), and is responsible for the antiapoptotic effect on neuronal death and the prevention of ischemic brain damage (60,61).…”