Araloside A, an Antiulcer Constituent from the Root Bark of Aralia elata

Triterpenoid Saponins from the Seeds of Pharbitis nil

“…In the 13 C-NMR spectrum, the signal due to the C-30 hydroxymethyl carbon at d 65.6 in 1 was displaced by a methyl carbon at d 24.9 in 2. All other signals were almost superimposable between 1 and 2, with the exception of signals for C-16, 21, and C-22 of the aglycon, as shown in Ta Comparison of the 13 C-NMR data of the aglycon moiety of 2 with oleanolic acid 17) showed that the signals for C-19 and 29-CH 3 of the aglycon were significantly shifted upfield by Ϫ5.1 ppm, respectively, due to a g-gauche effect, 20) which was consistent with the presence of the C-21 axial (a) hydroxyl group. Therefore, the structure of the aglycon was determined to be 21a-hydroxyoleanolic acid.…”

“…There have been several reports on the isolation of resin glycosides, [2][3][4] a diterpenoid, pharbitic acid, 5) flavonoids, caffeic acid, and chlorogenic acid derivatives, 6) and anthocyanins [7][8][9][10] from the seeds and flowers of this plant but there has been no report on the chemical investigation of the saponins in the seeds. In continuation of our studies on phytochemical studies on naturally occurring bioactive glycosides, [11][12][13][14] we became interested in the saponin content of the seeds of the plant. This paper describes the structural determination of the two new saponins isolated from the MeOH extract of the seeds.…”

Studies on gastroprotective activity of ethyl acetate leave fraction obtained from Canthium coromandelicum (Burm.f.) Alston in albino rats

“…Meanwhile, the total acidity was reduced in 100 and 200 mg/kg b.w. of EA-MECC about 55 The secretion of pepsin in to gastric juice was also significantly (p<0.0001) decreased in treatment groups in dose depended manner of EA-MECC. Both the doses reduced the pepsin content about 41.01% and 71.06% respectively as compared with control.…”

“…Like flavonoids, saponins were also exerting their protective activities in ulceration by the activation of mucus membrane protective factors [54] . They act mainly through antisecretary mechanism by inhibiting acid secretion, total acid output and lowered PH value of gastric juice [55] . Similarly, tannins are known to "tan" the outer layer of mucosa and it allows less permeable and strong resistant to chemical and mechanical injury or irritation [56] .…”

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“…According to phylogenic and biogeographic analysis, approximately sixty eight accepted species of genus Aralia (Family Araliaceae) are distributed in Asia and North America [1][2][3] . Several species of genus Aralia have pharmacological importance [4][5][6][7][8] and have been used in traditional medicine to treat rheumatic arthritis, nephritis, lumbago, lameness [9][10][11] , gastritis 12 inflammation 13 and diabetes mellitus 14 .…”