Arando na profilaxia das infecções urinárias recorrentes: Revisão baseada na evidência

Abstract

Introduction: Urinary tract infections (UTIs) are an important health problem, both in terms of morbidity and economic impact. Emerging antibiotic resistance increases the need for alternative preventive approaches. Aim: To review the available evidence on the efficacy of cranberries in preventing recurrent uncomplicated UTIs in adult women. Sources: MEDLINE database and the following evidence based medical sites: UpToDate, Clinical Evidence, Bandolier, EBM Online, ACP Journal Club, TRIP, InfoPOEMs, The Cochrane Library, DARE, Guidelines Finder, National Guideline Clearinghouse, Canadian Medical Association Infobase, USPSTF, NIC and Canadian Task Force on Preventive Health Care. Methods: Search for systematic reviews, meta-analyses, clinical guidelines and randomized clinical trials published between January 2000 and December 2010 in English, Portuguese and Spanish. We used the MeSH terms: Vaccinium macrocarpon and UTI and the word cranberry. The American Family Physician`s Strength of Recommendation Taxonomy was used to establish the quality of the studies and define the strength of the recommendation. Results: Of the 127 articles found, only nine fulfilled the inclusion criteria and were selected. These included one clinical decision support system, three systematic reviews, four clinical guidelines and one clinical trial. In its various forms, cranberries seem to effectively decrease the recurrence of UTIs in adult women without associated comorbidities Discussion: Available evidence shows that cranberries are beneficial in preventing recurrent urinary infections (Strength of Recommendation B). However, this recommendation is limited by the heterogeneity of studies and lack of agreement concerning dosage and presentation. Better studies are needed to establish safety and tolerability as well as the adequate dosage, presentation and duration of the treatment.

Infecções Do Trato Urinário: Uma Revisão Sobre as Evidências Científicas Das Principais Plantas Medicinais Utilizadas Na Prática Clínica

“…As ITUr em mulheres têm um grande impacto em termos de morbidade e custos em saúde, por isso é fundamental a sua prevenção. As cistites agudas não complicadas são frequentes em mulheres adultas e aproximadamente um terço destas mulheres apresenta ITU recorrente (21).…”

Avaliação in Vitro Do Extrato De Cranberry Em Cepas Isoladas De Exames De Urina De Rotina Na Terceira Idade

“…Após a análise e correlação do exame EAS com a urocultura, foi testado o perfil de sensibilidade da solução do pó de cranberry (Cranberry CR -Herbarium), o qual se apresentou eficaz de maneira em que foi exibido ações inibitórias e bactericidas nas cepas clínicas. Estudos comprovam que o fruto possui um mecanismo de ação baseado no poder das proantocianidinas e a frutose de inibirem a aderência das fímbrias das bactérias uropatogênicas às células do tecido epitelial, inibindo o desenvolvimento e proliferação bacteriana (PINA, et al, 2011).…”