Arbuscular mycorrhizal symbiosis modulates the apocarotenoid biosynthetic pathway in saffron

Stelluti, Stefania; Grasso, Gianluca; Nebauer, Sergio G.; Alonso, Gonzalo Luis; Renau-Morata, Begoña; Caser, Matteo; Demasi, Sonia; Lumini, Erica; Gómez-Gómez, María Lourdes; Molina, Rosa Victoria; Bianciotto, Valeria; Scariot, Valentina

doi:10.1016/j.scienta.2023.112441

Cited by 2 publications

(1 citation statement)

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“…Carotenoid cleavage oxygenases (CCOs) are a class of enzymes that can specifically catalyze the oxidative cleavage of various unsaturated bonds in carotenoids to produce secondary carotenoid metabolites. Depending on the substrate and double-bond specificity, CCOs can be divided into 9-cis-epoxycarotenoid cleavage dioxygenases (NCEDs), which generate abscisic acid, and carotenoid cleavage dioxygenases (CCDs), which are involved in the biosynthesis of crocin and other carotenoids [91,92]. Zeaxanthin cleavage dioxygenase (ZCD), which is considered to be the main CCD in C. sativus, can cleave zeaxanthin to generate crocetin dialdehyde in the stigma of C. sativus [93].…”

Section: Biosynthesis Of Crocin In C Sativusmentioning

confidence: 99%

Research Progress in Heterologous Crocin Production

Zhou,

Huang,

Liu

et al. 2023

Marine Drugs

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Crocin is one of the most valuable components of the Chinese medicinal plant Crocus sativus and is widely used in the food, cosmetics, and pharmaceutical industries. Traditional planting of C. sativus is unable to fulfill the increasing demand for crocin in the global market, however, such that researchers have turned their attention to the heterologous production of crocin in a variety of hosts. At present, there are reports of successful heterologous production of crocin in Escherichia coli, Saccharomyces cerevisiae, microalgae, and plants that do not naturally produce crocin. Of these, the microalga Dunaliella salina, which produces high levels of β-carotene, the substrate for crocin biosynthesis, is worthy of attention. This article describes the biosynthesis of crocin, compares the features of each heterologous host, and clarifies the requirements for efficient production of crocin in microalgae.

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Section: Biosynthesis Of Crocin In C Sativusmentioning

confidence: 99%