Arbutamine: A Novel Catecholamine for Pharmacologie Diagnosis of Coronary Disease

Young, Mark A.; Valcke, C; Mullane, Kevin; Gardiner, Peter

doi:10.1111/j.1527-3466.1995.tb00221.x

Cited by 4 publications

(1 citation statement)

References 45 publications

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“…Simulink software is the industry-standard tool for modeling and simulating, multivariate, and dynamic responses in biological systems. [14][15][16]…”

Section: Proposed Dismentioning

confidence: 99%

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Chandramouli¹

2020

AJP

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Aim: Managing hypertensive emergencies are a common occurrence in critical care setups. Mean arterial pressure (MAP) is an important hemodynamic variable indicative of hypertensive control and its regulation and needs to be controlled by a constrained set of physiological values. Materials and Methods: Sodium nitroprusside is a potent vasoactive drug which is used in the critical care setups to regulate hypertensive emergencies, administered through intravenous route. Many closed-loop drug infusion systems (CL-DIS) powered by fuzzy logic, artificial neural networks, and state-space models have been used to regulate the infusion. In this work, an attempt using proportional resonance controller and fractional-order proportional integral derivative (PID) with a closed loop is modeled and simulated. Results and Discussion: This work proposes a CL-DIS-based proportional resonance controller and fractional-order PID controller, which will respond rationally to the changes in the patient's condition and activate drug infusion to continue the MAP at the set physiological values of 60 and 70 mmHg. Conclusion:The planned controller setup has potential to be used as a controller for intravenous infusion of drugs and in our work maintained the MAP constrained by set values for the time domain responses for ideal physiological set points.

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“…Simulink software is the industry-standard tool for modeling and simulating, multivariate, and dynamic responses in biological systems. [14][15][16]…”

Section: Proposed Dismentioning

confidence: 99%

Untitled

Chandramouli¹

2020

AJP

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A comparison of adenosine and arbutamine for myocardial perfusion imaging

Anagnostopoulos

Pennell

Francis

et al. 1998

European Journal of Nuclear Medicine and Molecular Imaging

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We have compared our standard stress protocol (adenosine combined with exercise) with the new stress agent arbutamine, for thallium-201 myocardial perfusion imaging (MPI) in order to assess the comparative value of arbutamine. We studied 23 patients referred for MPI, and each patient had two studies (18 males, median age 66 years, five with previous myocardial infarction). Uptake scores were assigned to each of nine segments, and the extent and severity of defects were measured using a polar plot. Haemodynamic changes were greater with arbutamine (rate-pressure product increase 78% vs 51%, P = 0.003). Symptoms were experienced by 21 patients with arbutamine and 16 with adenosine (P = 0.07). Agreement between the techniques for classification of patients as normal or as having reversible, fixed or mixed defects was good (19 of 23 studies, 83%, kappa = 0.76). Agreement for similar classification of segments was also good (82%, kappa = 0.71). Segmental agreement for stress scores was good (86%, kappa = 0.77). However, mean size of stress defect was larger with adenosine (83+/-52 pixels vs 65+/-48 pixels, P<0.05), though severity and reversibility were similar (P = NS). We conclude that arbutamine provides comparable results to those obtained with adenosine and exercise and that the observed differences are not clinically significant.

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Closed-loop drug infusion for control of heart-rate trajectory in pharmacological stress tests

Valcke

Chizeck

1997

IEEE Trans. Biomed. Eng.

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The diagnosis of coronary artery disease (CAD) is an important task in the management of cardiology patients. Recently, the use of pharmacological stress testing has become available as an alternative to exercise stress testing (ETT). A new system (device-drug combination) was developed specifically for the diagnosis of coronary artery disease. The system uses a novel catecholamine, arbutamine, which is infused intravenously to increase heart rate (HR) and cardiac contractility in order to evoke signs of ischemia. The development of a closed-loop control algorithm for the delivery of this drug and a pharmacodynamic (PD) model representing the HR response to arbutamine infusions are presented. Model parameters are estimated from clinical data on normal volunteers and patients. Based on this mathematical model, a rule-based control algorithm is designed. The structure of the control algorithm is discussed and testing of the algorithm based on simulations and animal and human trials are summarized. Results from clinical trials shows that the algorithm controls the HR increase according to a selected trajectory. The automated delivery of the drug can provide the cardiologist with an efficient, effective, and safe method for administering a pharmacological stress test.

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Arbutamine: A Novel Catecholamine for Pharmacologie Diagnosis of Coronary Disease

Cited by 4 publications

References 45 publications

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A comparison of adenosine and arbutamine for myocardial perfusion imaging

Closed-loop drug infusion for control of heart-rate trajectory in pharmacological stress tests

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