Arc/Arg3.1 Is Essential for the Consolidation of Synaptic Plasticity and Memories

Plath, Niels; Ohana, Ora; Dammermann, Björn; Errington, Mick L.; Schmitz, Dietmar; Groß, Christina; Mao, Xiaosong; Engelsberg, Arne; Mahlke, Claudia; Welzl, Hans; Kobalz, Ursula; Stawrakakis, Anastasia; Fernández, Esperanza; Waltereit, Robert; Bick-Sander, Anika; Therstappen, Eric; Cooke, Sam; Blanquet, Véronique; Wurst, Wolfgang; Salmen, Benedikt; Bösl, Michael R.; Lipp, Hans‐Peter; Grant, Seth G. N.; Bliss, T. V. P.; Wolfer, David P; Kuhl, Dietmar

doi:10.1016/j.neuron.2006.08.024

Cited by 755 publications

(726 citation statements)

References 43 publications

(41 reference statements)

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“…A recent study in this Journal (Gallitano-Mendel, Izumi et al 2007) found that when the transcriptional IEG Egr3 is knocked out, mice show a hyperactive response in the open field. These authors suggest that the absence of this IEG, which transcribes the effector IEG Arc (Li, Carter et al 2005) and regulates long term potentiation (LTP) and long term depression (LTD) of neuronal synapses (Plath, Ohana et al 2006), results in open field hyperactivity due to decreased habituation to its novelty. Consistent with this, impaired expression of the IEG Arc is associated with deficient long term memory and increased exploration of a novel object (Plath, Ohana et al 2006).…”

Section: Link Between Between Behavioral and Ieg Changes During Isolamentioning

confidence: 99%

“…These authors suggest that the absence of this IEG, which transcribes the effector IEG Arc (Li, Carter et al 2005) and regulates long term potentiation (LTP) and long term depression (LTD) of neuronal synapses (Plath, Ohana et al 2006), results in open field hyperactivity due to decreased habituation to its novelty. Consistent with this, impaired expression of the IEG Arc is associated with deficient long term memory and increased exploration of a novel object (Plath, Ohana et al 2006). LTD (which is associated with altered IEG expression) is also associated with impaired spatial memory (Nakao, Ikegaya et al 2002) and brief exposure to stressful situations (Xu, Anwyl et al 1997).…”

Section: Link Between Between Behavioral and Ieg Changes During Isolamentioning

confidence: 99%

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Isolation rearing impairs wound healing and is associated with increased locomotion and decreased immediate early gene expression in the medial prefrontal cortex of juvenile rats

Levine¹,

Leeder²,

Parekkadan³

et al. 2008

Neuroscience

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In addition to its maladaptive effects on psychiatric function, psychosocial deprivation impairs recovery from physical illness. Previously, we found that psychosocial deprivation, modeled by isolation rearing, depressed immediate early gene (IEG) expression in the medial prefrontal cortex (mPFC) and increased locomotion in the open field test (Levine, Youngs et al. 2007). In the present study, we examined whether similar changes in behavior and gene expression are associated with the maladaptive effects of psychosocial deprivation on physical injury healing. After weaning, anesthetized rats were subjected to a 20% total body surface area third degree burn injury and were subsequently either group or isolation reared. After four weeks of either isolation or group rearing (a period that encompasses rodent childhood and early adolescence), rats were sacrificed, and their healing and gene expression in the mPFC were assessed. Locomotion in the open field test was examined at 3 weeks post burn injury. We found that: 1) gross wound healing was significantly impaired in isolation reared rats compared to group reared rats, 2) locomotion was increased and IEG expression was suppressed for isolation reared rats during burn injury healing, 3) the decreased activity in the open field and increased IEG expression was greater for burn injury healing group reared rats than for uninjured group reared rats, 4) the degree of hyperactivity and IEG suppression was relatively similar between isolation reared rats during burn injury compared to uninjured isolation reared rats, 5) behavioral hyperactivity to novelty (the open

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Section: Link Between Between Behavioral and Ieg Changes During Isolamentioning

confidence: 99%

Section: Link Between Between Behavioral and Ieg Changes During Isolamentioning

confidence: 99%

Isolation rearing impairs wound healing and is associated with increased locomotion and decreased immediate early gene expression in the medial prefrontal cortex of juvenile rats

Levine¹,

Leeder²,

Parekkadan³

et al. 2008

Neuroscience

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“…IEGs, like the transcription factors, c-fos and zif/268, and the effector, activity-regulated cytoskeleton-associated gene (arc), contribute to the promotion and maintenance of synaptic plasticity (Rial Verde et al 2006), associative learning Malkani et al 2004), and long-term storage and retrieval of memories (Guzowski et al 2000;Hall et al 2001;Thomas et al 2002;Bozon et al 2003;Plath et al 2006). The expression of all of these IEGs is transiently induced by cocaine (Graybiel et al 1990;Young et al 1991;Moratalla et al 1992;Bhat and Baraban 1993;McGinty 1994, 1995;Fosnaugh et al 1995;Tan et al 2000;Fumagalli et al 2006) and cocaineassociated cues (Brown et al 1992;Crawford et al 1995;Everitt and Robbins 2000;Neisewander et al 2000;Ciccocioppo et al 2001;Thomas et al 2003: Zavala et al 2007).…”

Section: Introductionmentioning

confidence: 99%

Relapse to cocaine-seeking increases activity-regulated gene expression differentially in the striatum and cerebral cortex of rats following short or long periods of abstinence

2008

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One of the most insidious features of cocaine addiction is a high rate of relapse even after extended periods of abstinence. A wide variety of drug-associated stimuli, including the context in which a drug is taken, can gain incentive motivational properties that trigger drug desire and relapse to drug-seeking. Both animal and clinical studies suggest that extensive cocaine exposure may induce a transition from cortical to striatal control over decision-making as compulsive drugseeking emerges. Using an animal model of relapse to cocaine-seeking, the present study investigated the expression patterns of three different activity-related genes (c-fos, zif/268, and arc) in cortical and striatal brain regions implicated in compulsive drug-seeking in order to determine the neuroadaptations that occur during context-induced relapse following brief or prolonged abstinence from cocaine self-administration. Re-exposure to the environment previously associated with cocaine self-administration following 22 h or 15 days of abstinence produced a significant increase in zif/268 and arc, but not c-fos mRNA, in the caudate-putamen and nucleus accumbens. With the exception of arc mRNA levels following 15 days of abstinence, all three genes were increased in the anterior cingulate cortex of animals with a cocaine history when they were re-exposed to the operant chamber. Additionally, c-fos, zif/268, and arc expression was differentially affected in the motor and sensory cortices at both timepoints. Together, these results support convergent evidence that drug-seeking induced by a cocaine-paired context changes the activity of corticostriatal circuits.

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“…Okuno et al (12) reported that Arc plays a role in the inverse synaptic tagging of silent synapses; Arc accumulated in silent synapses to reduce surface AMPA receptors (12). Thus, Arc is a unique molecule involved in the control of synaptic plasticity (10,13,14). Kawashima et al (4) demonstrated that a distal enhancer, synaptic activity-responsive element (SARE), which contains binding sites for cAMP-response element (CRE)-binding protein (CREB), myocyte enhancer factor 2 (MEF2), and serum response factor (SRF), located Ϫ7 kbp upstream of the Arc transcription start site, was essential for activity-dependent transcriptional activation of Arc (4).…”

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confidence: 99%

Class I Histone Deacetylase-mediated Repression of the Proximal Promoter of the Activity-regulated Cytoskeleton-associated Protein Gene Regulates Its Response to Brain-derived Neurotrophic Factor

Nakashima

Tabuchi

Shimotori

et al. 2015

Journal of Biological Chemistry

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Background: Activity-regulated cytoskeleton-associated protein (Arc) transcription is activated by BDNF. Results: BDNF activated the Arc proximal promoter, whereas class I histone deacetylases (HDACs) inhibited this activation. Conclusion: Class I HDACs repress BDNF-induced Arc transcription through its serum response element-containing proximal promoter. Significance: Neuronal Arc expression is regulated by chromatin structure, which may lead to long-lasting changes in neuronal functions.

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Arc/Arg3.1 Is Essential for the Consolidation of Synaptic Plasticity and Memories

Cited by 755 publications

References 43 publications

Isolation rearing impairs wound healing and is associated with increased locomotion and decreased immediate early gene expression in the medial prefrontal cortex of juvenile rats

Isolation rearing impairs wound healing and is associated with increased locomotion and decreased immediate early gene expression in the medial prefrontal cortex of juvenile rats

Relapse to cocaine-seeking increases activity-regulated gene expression differentially in the striatum and cerebral cortex of rats following short or long periods of abstinence

Class I Histone Deacetylase-mediated Repression of the Proximal Promoter of the Activity-regulated Cytoskeleton-associated Protein Gene Regulates Its Response to Brain-derived Neurotrophic Factor

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