We describe a multi-segmented foot model comprising lower leg, rearfoot, midfoot, lateral forefoot, medial forefoot, and hallux for routine use in a clinical setting. The Ghent Foot Model describes the kinematic patterns of functional units of the foot, especially the midfoot, to investigate patient populations where midfoot deformation or dysfunction is an important feature, for example, rheumatoid arthritis patients. Data were obtained from surface markers by a 6 camera motion capture system at 500 Hz. Ten healthy subjects walked barefoot along a 12 m walkway at self-selected speed. Joint angles (rearfoot to shank, midfoot to rearfoot, lateral and medial forefoot to midfoot, and hallux to medial forefoot) in the sagittal, frontal, and transverse plane are reported according to anatomically based reference frames. These angles were calculated and reported during the foot rollover phases in stance, detected by synchronized plantar pressure measurements. Repeated measurements of each subject revealed low intra-subject variability, varying between 0.78 and 2.38 for the minimum values, between 0.58 and 2.18 for the maximum values, and between 0.88 and 5.88 for the ROM. The described movement patterns were repeatable and consistent with biomechanical and clinical knowledge. As such, the Ghent Foot model permits intersegment, in vivo motion measurement of the foot, which is crucial for both clinical and research applications. Keywords: multi-segment foot model; foot and ankle kinematics; gait analysis; Ghent Foot Model Multi-segmented foot models can provide better insight into foot kinematics (and to a less extent segmental foot kinetics) during gait than single segments models. Clinically, they are used to describe and analyze functional characteristics associated with foot impairments. A number of multi-segmented foot models, using either bone pins or surface markers, have been proposed. They vary according to the number of segments and functional unit definition, in the methods of calculating intersegment angles, and in the definition of the neutral foot reference position. 1,2The need exists for a clinically relevant, user-friendly multi-segment foot model that would include the lower leg, hindfoot, midfoot, medial and lateral forefoot, and the hallux, with wide utility to investigate single joint/segment joint dysfunction through to complex foot deformities. Models with <5 segments often can not describe whole foot kinematics. [3][4][5][6][7] In contrast, those with nine segments 8 are not always easily applicable in clinical settings. To our knowledge and based upon a recent review, 2 no such model is currently available.There are two main reasons why a 6 segment model is clinically relevant. First, these segments are examined clinically by physical therapists and podiatrists. The medial arch, formed by the rearfoot (talus), the medial part of the midfoot, and the first ray, plays an important role in foot function during weight bearing activities. 9 Different arch configurations are an intrinsic ris...