Archaeometric analysis of the pottery from the Chalcolithic site of El Cortijo de Montiel Bajo (Santo Tomé de la Vega, Jaén, Spain)

Granja, Paula Pinillos de la; Alejos, Alberto Dorado; Serrano, Juan Antonio Cámara; Bareas, Cristóbal Pérez

doi:10.1007/s12520-022-01652-w

Cited by 2 publications

(1 citation statement)

References 62 publications

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“…TME has many different physicochemical properties compared to the normal human internal environment, especially its low oxygen, low pH, and high-stress characteristics [ 79 ], it includes all non-malignant host cells and non-cellular components [ 80 , 81 ], and it includes, without limitation, the immune system, blood cells, endothelial cells, adipocytes, and stroma [ 82 ]. Also, TME has a large number of growth factors, cell chemokines, and diverse protein hydrolases in TME, which are extremely favorable for tumor proliferation, invasion, adhesion, and angiogenesis.…”

Section: Active Targeting Of Drug Deliverymentioning

confidence: 99%

Recent Advances in Targeted Drug Delivery Strategy for Enhancing Oncotherapy

Li,

Wang,

Xia

et al. 2023

Pharmaceutics

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Targeted drug delivery is a precise and effective strategy in oncotherapy that can accurately deliver drugs to tumor cells or tissues to enhance their therapeutic effect and, meanwhile, weaken their undesirable side effects on normal cells or tissues. In this research field, a large number of researchers have achieved significant breakthroughs and advances in oncotherapy. Typically, nanocarriers as a promising drug delivery strategy can effectively deliver drugs to the tumor site through enhanced permeability and retention (EPR) effect-mediated passive targeting and various types of receptor-mediated active targeting, respectively. Herein, we review recent targeted drug delivery strategies and technologies for enhancing oncotherapy. In addition, we also review two mainstream drug delivery strategies, passive and active targeting, based on various nanocarriers for enhancing tumor therapy. Meanwhile, a comparison and combination of passive and active targeting are also carried out. Furthermore, we discuss the associated challenges of passive and active targeted drug delivery strategies and the prospects for further study.

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Section: Active Targeting Of Drug Deliverymentioning

confidence: 99%

Recent Advances in Targeted Drug Delivery Strategy for Enhancing Oncotherapy

Li,

Wang,

Xia

et al. 2023

Pharmaceutics

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¿Época de cambios? La cerámica del Cobre Tardío (2600?2400 a. C.) de Los Castillejos (Montefrío, Granada)

López-López,

Gámiz Caro,

Cámara Serrano

2023

CuPAUAM

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El presente trabajo estudia de manera exhaustiva y sistemática el complejo cerámico de las fases 20 y 21 del poblado prehistórico de Los Castillejos en Las Peñas de los Gitanos (Montefrío, Granada), recuperado de las excavaciones realizadas entre 1991 y 1994. Dichas fases se adscriben cronológicamente al Cobre Tardío (2600-2400 a. C.), caracterizado por la intensificación de ciertas dinámicas económicas y sociales así como por la irrupción del llamado fenómeno campaniforme en la península ibérica. A través del empleo de una metodología que pasa por el estudio tecnológico de las pastas mediante estereomicroscopio y análisis mineralógico (DRX), la elaboración de una tipología y el estudio de la decoración de las muestras, se han podido detectar continuidades y discontinuidades en las tradiciones alfareras. Los cambios detectados a nivel tecnológico coinciden con otros atestiguados en el ámbito del consumo y del paleoambiente, dando cuenta de una posible y marcada época de transformaciones sociales y económicas a finales del III milenio a. C.

show abstract

Archaeometric analysis of the pottery from the Chalcolithic site of El Cortijo de Montiel Bajo (Santo Tomé de la Vega, Jaén, Spain)

Cited by 2 publications

References 62 publications

Recent Advances in Targeted Drug Delivery Strategy for Enhancing Oncotherapy

Recent Advances in Targeted Drug Delivery Strategy for Enhancing Oncotherapy

¿Época de cambios? La cerámica del Cobre Tardío (2600?2400 a. C.) de Los Castillejos (Montefrío, Granada)

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