Architects in neural circuit design: Glia control neuron numbers and connectivity

Corty, Megan M.; Freeman, Marc

doi:10.1083/jcb.201306099

Cited by 77 publications

(71 citation statements)

References 79 publications

(127 reference statements)

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“…A role for neurons and glia in regulating the death of their parental stem cells has important implications for how we think about the composition and role of the stem cell niche, and may influence the design and implementation of stem cell-based therapies for disease. 51 Materials and methods Fly stocks and genotypes. Flies were raised at 25°C.…”

Section: Discussionmentioning

confidence: 99%

Neural stem cell progeny regulate stem cell death in a Notch and Hox dependent manner

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Neural stem cell progeny regulate stem cell death in a Notch and Hox dependent manner

et al. 2015

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“…In turn, glial responses to drugs of abuse could influence neuronal function directly through physical remodeling of structural components (Brown and Neher, 2014;Corty and Freeman, 2013), as described in the previous section, or indirectly through a variety of released compounds (see Block et al, 2007). This chemical communication from glia can be both anti-inflammatory and neuroprotective (eg, IL-10, TGF-β, and BDNF) or proinflammatory and neurotoxic (eg, IL-1β, TNFα, and NADPH oxidase) (see Figure 1).…”

Section: Opioids Glia and Neuroimmune Signalingmentioning

confidence: 99%

Glial and Neuroimmune Mechanisms as Critical Modulators of Drug Use and Abuse

Lacagnina

Rivera

Bilbo

2016

Neuropsychopharmacol

223

170

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Drugs of abuse cause persistent alterations in synaptic plasticity that may underlie addiction behaviors. Evidence suggests glial cells have an essential and underappreciated role in the development and maintenance of drug abuse by influencing neuronal and synaptic functions in multifaceted ways. Microglia and astrocytes perform critical functions in synapse formation and refinement in the developing brain, and there is growing evidence that disruptions in glial function may be implicated in numerous neurological disorders throughout the lifespan. Linking evidence of function in health and under pathological conditions, this review will outline the glial and neuroimmune mechanisms that may contribute to drug-abuse liability, exploring evidence from opioids, alcohol, and psychostimulants. Drugs of abuse can activate microglia and astrocytes through signaling at innate immune receptors, which in turn influence neuronal function not only through secretion of soluble factors (eg, cytokines and chemokines) but also potentially through direct remodeling of the synapses. In sum, this review will argue that neural-glial interactions represent an important avenue for advancing our understanding of substance abuse disorders.

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“…Despite this, many fundamental aspects of glia, such as their spatial proximity and relative distribution to neurons, remain mysterious. Thus, a comprehensive analysis of glial cell number, morphology, and their location in proximity to neurons would be extremely valuable for understanding glia-mediated neuronal functions and their detailed roles in circuitry [2,8,13].…”

Section: Introductionmentioning

confidence: 99%

Analysis of Glial Distribution in Drosophila Adult Brains

Gao

et al. 2016

Neurosci. Bull.

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Neurons and glia are the two major cell types in the nervous system and work closely with each other to program neuronal interplay. Traditionally, neurons are thought to be the major cells that actively regulate processes like synapse formation, plasticity, and behavioral output. Glia, on the other hand, serve a more supporting role. To date, accumulating evidence has suggested that glia are active participants in virtually every aspect of neuronal function. Despite this, fundamental features of how glia interact with neurons, and their spatial relationships, remain elusive. Here, we describe the glial cell population in Drosophila adult brains. Glial cells extend and tightly associate their processes with major structures such as the mushroom body (MB), ellipsoid body (EB), and antennal lobe (AL) in the brain. Glial cells are distributed in a more concentrated manner in the MB. Furthermore, subsets of glia exhibit distinctive association patterns around different neuronal structures. Whereas processes extended by astrocyte-like glia and ensheathing glia wrap around the MB and infiltrate into the EB and AL, cortex glia stay where cell bodies of neurons are and remain outside of the synaptic regions structured by EB or AL.

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Architects in neural circuit design: Glia control neuron numbers and connectivity

Cited by 77 publications

References 79 publications

Neural stem cell progeny regulate stem cell death in a Notch and Hox dependent manner

Neural stem cell progeny regulate stem cell death in a Notch and Hox dependent manner

Glial and Neuroimmune Mechanisms as Critical Modulators of Drug Use and Abuse

Analysis of Glial Distribution in Drosophila Adult Brains

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