Architectural and Fiber Type Distribution Properties of Selected Rhesus Leg Muscles: Feasibility of Multiple Independent Biopsies

Roy, Roland R.; Bodine, Sue C.; Kim, J.; Haque, N.; Leon, D. De; Rudolph, W; Edgerton, V. Reggie

doi:10.1159/000147081

Cited by 24 publications

(14 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In agreement with histoenzymatic studies in nonhuman primates [15,18,19,42,43) and other mammals [44|, we found significant variations between the superficial and deep parts of the various muscles, with the exception of the relatively homo geneous soleus. Maximum heterogeneity of fibre percentages was found in triceps medialis (newborn as well as adult).…”

Section: Resultssupporting

confidence: 91%

Developmental Changes in the Fibre Composition of Elbow, Knee, and Ankle Extensor Muscles in Cercopithecid Monkeys

Jouffroy

Médina²

1996

IJFP

View full text Add to dashboard Cite

Developmental changes of muscle fibre composition in the various heads of the elbow, knee, and ankle extensors have been studied in three genera of cercopithecid monkeys. In order to circumvent the technical hindrances of usual histoenzymological procedures (fresh muscles need to be frozen at once at -80 °C), immunofluorescence methods were used and technical adjustments were successfully carried out to make the study of formaldehyde-preserved muscles possible. Clear responses to antibodies against adult fast myosin in newborn macaques demonstrated that, at birth, adult myosins have already replaced the fetal isoforms, thus providing a reliable marker for the study of postnatal evolution of the muscle fibre composition. For each one of the three joints, from birth to adulthood, the percentage of slow, fatigue-resistant fibres increases only in that head of the extensor muscle groups which is specialized in maintaining posture by counteracting gravity (the ‘postural’ head). Hence, the question is raised of the relationships between such cytological evolution, developmental changes in postural behaviour, and body weight increase.

show abstract

Section: Resultssupporting

confidence: 91%

Developmental Changes in the Fibre Composition of Elbow, Knee, and Ankle Extensor Muscles in Cercopithecid Monkeys

Jouffroy

Médina²

1996

IJFP

View full text Add to dashboard Cite

show abstract

“…Each muscle was sampled at one location, and this biopsy was considered representative of the entire muscle, thereby assuming that regional variation within a muscle is smaller than variation between muscles. This assumption is supported by past work in rhesus monkeys, where fiber-type percentage variability between subjects was demonstrated to be much greater than between biopsies within a muscle in a single subject (Roy et al, 1991), and in human paraspinal muscles, where fiber-type distribution was independent of biopsy depth (Regev et al, 2010).…”

Section: Limitationsmentioning

confidence: 54%

Human skeletal muscle biochemical diversity

Tirrell

Cook

Carr

et al. 2012

Journal of Experimental Biology

View full text Add to dashboard Cite

SUMMARY The molecular components largely responsible for muscle attributes such as passive tension development (titin and collagen), active tension development (myosin heavy chain, MHC) and mechanosensitive signaling (titin) have been well studied in animals but less is known about their roles in humans. The purpose of this study was to perform a comprehensive analysis of titin, collagen and MHC isoform distributions in a large number of human muscles, to search for common themes and trends in the muscular organization of the human body. In this study, 599 biopsies were obtained from six human cadaveric donors (mean age 83 years). Three assays were performed on each biopsy – titin molecular mass determination, hydroxyproline content (a surrogate for collagen content) and MHC isoform distribution. Titin molecular mass was increased in more distal muscles of the upper and lower limbs. This trend was also observed for collagen. Percentage MHC-1 data followed a pattern similar to collagen in muscles of the upper extremity but this trend was reversed in the lower extremity. Titin molecular mass was the best predictor of anatomical region and muscle functional group. On average, human muscles had more slow myosin than other mammals. Also, larger titins were generally associated with faster muscles. These trends suggest that distal muscles should have higher passive tension than proximal ones, and that titin size variability may potentially act to ‘tune’ the protein's mechanotransduction capability.

show abstract

“…Another similarity between the Rhesus and other mammals was the differential recruitment of slow versus fast muscles with respect to speed of locomotion. For example, the MG muscle, composed of a high proportion of fast, fatigable motor units (Roy et al 1991a), was more heavily recruited at the faster than the slower speeds of locomotion, whereas the predominantly slow Sol muscle was already heavily recruited at the slower treadmill speeds (Figs. 7 and 8).…”

Section: Speed-related Changes In Gait Parameters and Muscle Activitymentioning

confidence: 99%

Kinematic and EMG Determinants in Quadrupedal Locomotion of a Non-Human Primate (Rhesus)

Courtine

Roy²,

Hodgson³

et al. 2005

Journal of Neurophysiology

134

102

View full text Add to dashboard Cite

. Kinematic and EMG determinants in quadrupedal locomotion of a non-human primate (Rhesus). J Neurophysiol 93: 3127-3145, 2005. First published January 12, 2005 doi:10.1152/jn.01073.2004. We hypothesized that the activation patterns of flexor and extensor muscles and the resulting kinematics of the forelimbs and hindlimbs during locomotion in the Rhesus would have unique characteristics relative to other quadrupedal mammals. Adaptations of limb movements and in motor pool recruitment patterns in accommodating a range of treadmill speeds similar to other terrestrial animals in both the hindlimb and forelimb were observed. Flexor and extensor motor neurons from motor pools in the lumbar segments, however, were more highly coordinated than in the cervical segments. Unlike the lateral sequence characterizing subprimate quadrupedal locomotion, non-human primates use diagonal coordination between the hindlimbs and forelimbs, similar to that observed in humans between the legs and arms. Although there was a high level of coordination between hind-and forelimb locomotion kinematics, limb-specific neural control strategies were evident in the intersegmental coordination patterns and limb endpoint trajectories. Based on limb kinematics and muscle recruitment patterns, it appears that the hindlimbs, and notably the distal extremities, contribute more to body propulsion than the forelimbs. Furthermore, we found adaptive changes in the recruitment patterns of distal muscles in the hind-and forelimb with increased treadmill speed that likely correlate with the anatomical and functional evolution of hand and foot digits in monkeys. Changes in the properties of both the spinal and supraspinal circuitry related to stepping, probably account for the peculiarities in the kinematic and EMG properties during non-human primate locomotion. We suggest that such adaptive changes may have facilitated evolution toward bipedal locomotion.

show abstract

Architectural and Fiber Type Distribution Properties of Selected Rhesus Leg Muscles: Feasibility of Multiple Independent Biopsies

Cited by 24 publications

References 21 publications

Developmental Changes in the Fibre Composition of Elbow, Knee, and Ankle Extensor Muscles in Cercopithecid Monkeys

Developmental Changes in the Fibre Composition of Elbow, Knee, and Ankle Extensor Muscles in Cercopithecid Monkeys

Human skeletal muscle biochemical diversity

Kinematic and EMG Determinants in Quadrupedal Locomotion of a Non-Human Primate (Rhesus)

Contact Info

Product

Resources

About