ARCON: a novel biology-based approach in radiotherapy

Kaanders, J.H.A.M.; Bussink, Johan; Kogel, Albert J. van der

doi:10.1016/s1470-2045(02)00929-4

Cited by 234 publications

(134 citation statements)

References 67 publications

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“…One vascular intervention currently being assessed for its ability to improve tumor oxygenation prior to radiotherapy is carbogen (95% CO 2 /5%O 2 ) breathing and nicotinamide in combination. 102 Increases in tumor GRE (gradient recalled echo) image intensity have been reported during carbogen breathing and during hyperoxia. 63,65,[103][104][105][106][107][108][109][110] The main cause of the GRE image intensity change is the increase in blood oxygenation through the breathing of a high-oxygen-content gas, reducing the dHb concentration of tumor blood vessels.…”

Section: Techniques For the Assessment Of Tumor Oxygenationmentioning

confidence: 99%

“…Breathing carbogen (possibly combined with nicotinamide administration) is now applied succesfully in the clinic together with irradiation. 102 The increase in pO 2 in tumors induced by breathing carbogen was shown in several tumor lines using EPR spectroscopy, 107,176,183,224 EPR imaging 146,160,159 or PEDRI. 163 Oxygen images were obtained in tumors before and after breathing carbogen by the group at the NCI using dynamic nuclear polarization and the extraction of T 2 of trityl radicals.…”

Section: Modulations Of Tumor Oxygenation By Modifying the Inspired Gasmentioning

confidence: 99%

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Assessment of tumor oxygenation by electron paramagnetic resonance: principles and applications

2004

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This review paper attempts to provide an overview of the principles and techniques that are often termed electron paramagnetic resonance (EPR) oximetry. The paper discusses the potential of such methods and illustrates they have been successfully applied to measure oxygen tension, an essential parameter of the tumor microenvironment. To help the reader understand the motivation for carrying out these measurements, the importance of tumor hypoxia is first discussed: the basic issues of why a tumor is hypoxic, why these hypoxic microenvironments promote processes driving malignant progression and why hypoxia dramatically influences the response of tumors to cytotoxic treatments will be explained. The different methods that have been used to estimate the oxygenation in tumors will be reviewed. To introduce the basics of EPR oximetry, the specificity of in vivo EPR will be discussed by comparing this technique with NMR and MRI. The different types of paramagnetic oxygen sensors will be presented, as well as the methods for recording the information (EPR spectroscopy, EPR imaging, dynamic nuclear polarization). Several applications of EPR for characterizing tumor oxygenation will be illustrated, with a special emphasis on pharmacological interventions that modulate the tumor microenvironment. Finally, the challenges for transposing the method into the clinic will also be discussed.

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Section: Techniques For the Assessment Of Tumor Oxygenationmentioning

confidence: 99%

Section: Modulations Of Tumor Oxygenation By Modifying the Inspired Gasmentioning

confidence: 99%

Assessment of tumor oxygenation by electron paramagnetic resonance: principles and applications

2004

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“…In contrast to previous strategies, the goal of the ''provascular'' approaches is to increase tumor perfusion and oxygenation temporarily through pharmacologic interventions. For this latter approach, radiotherapy could benefit from tumor reoxygenation because oxygen is a key factor in the response to irradiation (5). Additionally, a decrease in tumor interstitial pressure (6) or a normalization of the tumor vasculature at the early phase of an antiangiogenic treatment (7 -9) could facilitate tumor accessibility to circulating chemotherapeutic drugs.…”

mentioning

confidence: 99%

Botulinum toxin potentiates cancer radiotherapy and chemotherapy.

Ansiaux

Baudelet

Cron

et al. 2006

Clinical Cancer Research

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Purpose: Structural and functional abnormalities in the tumor vascular network are considered factors of resistance of solid tumors to cytotoxic treatments.To increase the efficacy of anticancer treatments, efforts must be made to find new strategies for transiently opening the tumor vascular bed to alleviate tumor hypoxia (source of resistance to radiotherapy) and improve the delivery of chemotherapeutic agents. We hypothesized that Botulinum neurotoxin type A (BoNT-A) could interfere with neurotransmitter release at the perivascular sympathetic varicosities, leading to inhibition of the neurogenic contractions of tumor vessels and therefore improving tumor perfusion and oxygenation. Experimental Design: To test this hypothesis, BoNT-A was injected locally into mouse tumors (fibrosarcoma FSaII, hepatocarcinoma transplantable liver tumor), and electron paramagnetic resonance oximetry was used to monitor pO 2 in vivo repeatedly for 4 days. Additionally, contrast-enhanced magnetic resonance imaging was used to measure tumor perfusion in vivo. Finally, isolated arteries were mounted in wire myograph to monitor specifically the neurogenic tone developed by arterioles that were co-opted by the surrounding growing tumor cells. Results: Using these tumor models, we showed that local administration of BoNT-A (two sites; dose, 29 units/kg) substantially increases tumor oxygenation and perfusion, leading to a substantial improvement in the tumor response to radiotherapy (20 Gy of 250-kV radiation) and chemotherapy (cyclophosphamide, 50 mg/kg). This observed therapeutic gain results from an opening of the tumor vascular bed by BoNT-A because we showed that BoNT-A could inhibit neurogenic tone in the tumor vasculature. Conclusions: The opening of the vascular bed induced by BoNT-A offers a way to significantly increase the response of tumors to radiotherapy and chemotherapy.

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“…The use of anatomical imaging such as CT or MRI alone to select patients for oncologic therapies, including chemotherapy, radiotherapy, and surgery, is insufficient. Noninvasive and repetitive measurements of biological tumor characteristics have the potential to predict which patients will benefit from a particular treatment and enable more specific patient selection (Bussink et al, 2011;Kaanders et al, 2002;Mandrekar and Sargent, 2010). While FDG-PET/CT is mainly used as a staging tool in current clinical practice, its potential is more far-reaching than that.…”

Section: Treatment Guidancementioning

confidence: 99%

Molecular imaging for personalized cancer care

2012

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Molecular imaging is rapidly gaining recognition as a tool with the capacity to improve every facet of cancer care. Molecular imaging in oncology can be defined as in vivo characterization and measurement of the key biomolecules and molecularly based events that are fundamental to the malignant state. This article outlines the basic principles of molecular imaging as applied in oncology with both established and emerging techniques. It provides examples of the advantages that current molecular imaging techniques offer for improving clinical cancer care as well as drug development. It also discusses the importance of molecular imaging for the emerging field of theranostics and offers a vision of how molecular imaging may one day be integrated with other diagnostic techniques to dramatically increase the efficiency and effectiveness of cancer care.

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ARCON: a novel biology-based approach in radiotherapy

Cited by 234 publications

References 67 publications

Assessment of tumor oxygenation by electron paramagnetic resonance: principles and applications

Assessment of tumor oxygenation by electron paramagnetic resonance: principles and applications

Botulinum toxin potentiates cancer radiotherapy and chemotherapy.

Molecular imaging for personalized cancer care

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