2019
DOI: 10.1016/j.lfs.2019.03.037
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Arctigenin ameliorates renal impairment and inhibits endoplasmic reticulum stress in diabetic db/db mice

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Cited by 24 publications
(16 citation statements)
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“…Histology evaluation. Renal tissues from the mice were fixed for 24 h at 20˚C in 10% neutral formalin, embedded in paraffin, manually sectioned into 4-µm thick tissue sections and stained with hematoxylin and eosin (H&e), periodic acid-Schiff (PaS) and Masson reagent as previously described (19,20). The paraffin-embedded renal tissue sections were analyzed using immunohistochemistry as described in our previous study (19).…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…Histology evaluation. Renal tissues from the mice were fixed for 24 h at 20˚C in 10% neutral formalin, embedded in paraffin, manually sectioned into 4-µm thick tissue sections and stained with hematoxylin and eosin (H&e), periodic acid-Schiff (PaS) and Masson reagent as previously described (19,20). The paraffin-embedded renal tissue sections were analyzed using immunohistochemistry as described in our previous study (19).…”
Section: Methodsmentioning
confidence: 99%
“…Renal tissues from the mice were fixed for 24 h at 20°C in 10% neutral formalin, embedded in paraffin, manually sectioned into 4-µm thick tissue sections and stained with hematoxylin and eosin (H&E), periodic acid-Schiff (PAS) and Masson reagent as previously described ( 19 , 20 ).…”
Section: Methodsmentioning
confidence: 99%
“…Arctigenin (ATG), a lignan extract from Fructus arctii , has renoprotective effects on diabetes-related renal injury by inhibiting ER stress and apoptosis [173]. It is not surprising that ATG also induces HO-1 [174].…”
Section: Diabetes Mellitusmentioning
confidence: 99%
“…These changes were accompanied by decreased expression of both ER stress-related markers and caspase 12 levels in the kidneys of db/db mice. In vitro, high glucose activated ER stress signal transduction pathway and induced cell apoptosis in HK2 cells, which were blocked by ATG [78]. Treatment with arctiin significantly decreased the levels of 24-h urinary albumin, prevented the sclerosis of glomeruli and effectively restored the glomerular filtration barrier damage by upregulating the expression of nephrin and podocin and downregulating HPSE level [79].…”
Section: Vasodilatory and Vasculoprotective Activitymentioning
confidence: 99%