Arctigenin attenuates CCl4-induced hepatotoxicity through suppressing matrix metalloproteinase-2 and oxidative stress

Abstract

Background In spite of the huge advances in recent medicine, there is no effective drug that completely protects the liver from toxic materials. This study was conducted to investigate the hepatoprotective effect of arctigenin from burdock (Arctium lappa) against carbon tetrachloride (CCl4)-induced liver injury. Results Arctigenin pre-administration reduced hepatotoxicity markers significantly as compared to CCl4 group. In addition, both silymarin and arctigenin declined matrix metalloproteinase-2 (MMP-2) in the serum (1177 ± 176), (978 ± 135) significantly as compared to CCl4 group (1734 ± 294). The hepatic antioxidant parameters (total glutathione, superoxide dismutase, and glutathione reductase) were significantly decreased after CCl4 injection, an effect that has been prevented by pre-administration of both silymarin and arctigenin. Histological examinations illustrated that arctigenin reduced CCl4 damage, where it decreased inflammation, congestion, and ballooning. Conclusions Arctigenin exerted a hepatoprotective effect against CCl4-induced liver damage in terms of suppressing MMP-2 and oxidative stress comparative to that of silymarin.

Role of dietary selenium in alleviating bisphenol A toxicity of liver albino rats: Histological, ultrastructural, and biomarker assessments

“…The injury also occurs in the form of central vein and hepatic sinusoidal dilatation, vascular congestion, and vacuolar degeneration as noticed by Dianzani et al (1969) and Kakar et al (2004). Such knowledge is in accordance with the Hassan et al (2012Hassan et al ( , 2013 and Eid et al (2015). Degenerative alterations in liver cells have also been observed by Boshra and Moustafa (2013), Mourad and Khadrawy (2012).…”

“…This study design of repeated serum biomarker measurements for each treatment provides a good opportunity to distinguish these effects of changes in BPA concentrations on liver function. Liver function activity of enzymes such as AST and ALT level was also increased compared with control rats (Hassan et al, 2012;Korkmaz et al, 2010). Nonetheless, a recovery of the balance relative to control rats was observed after being fed with Se concomitantly with BPA (Favier, 2003;Helal et al, 2016).…”

The Role of Pomegranate Peel Extract in Improving Hepatotoxicity, and hMSH2 Expression in CCI 4 -Treated Rats

“…An increase in their concentration is a symbol of liver injury and disease [24]. Our results showed that the serum levels of AST and ALT significantly increased in response to CCl 4 and this agreed with previous studies [18,25]. This increase in the serum levels of these enzymes has been associated with liver damage since they are usually produced from hepatocytes during hepatonecrosis [26].…”

Role of Psyllium Husk (Plantago ovata) on Liver Function Alterations Induced by Carbon Tetrachloride (CCl4) in Adult Male Albino Rats

“…AST is localized in the mitochondria whereas ALT is distributed throughout the cytoplasm, ALT is more specific to the liver and is thus a better parameter for detecting liver injury (Lee et al,2017, Palanivel et al,2008. Lipid peroxidation caused by CCl4 causes cell membrane disruption leading to increased cell membrane permeability and AST and ALT leakage out from the liver into the bloodstream which explains the elevation of these enzymes level in blood after administration of CCl4 (Hus et al,2020, Kanawati et al,2021. The treatment of intoxicated rats with PSH in PS+CCl4 reduced ALT and AST serum activities to the normal level.…”