Arctigenin but not arctiin acts as the major effective constituent of Arctium lappa L. fruit for attenuating colonic inflammatory response induced by dextran sulfate sodium in mice

Protective effect of the essential oil of Zanthoxylum myriacanthum var. pubescens against dextran sulfate sodium-induced intestinal inflammation in mice

“…Moreover, the overproduction of reactive oxygen species and nitrogen species in inflamed tissue can induce severe oxidative stress for IBD patients. To reduce this impairment, the redox-sensitive signaling pathway was activated and released related enzymes including MPO ( Wu et al, 2014 ). Immunohistochemical staining showed the high level of MPO and MMP-9 in colon tissue in the DSS-induced intestinal inflammation group and markedly decreased after MQEO treatment.…”

“…Colon length was measured and the distal part was excised for histological assessment with H&E staining. The degree of lesion was scored according to the previous report ( Wu et al, 2014 ) (Table S2).…”

“…Immunohistochemical analysis of colon sections was performed according to methods previously described ( Wu et al, 2014 ).…”

Arctigenin exerts anti-colitis efficacy through inhibiting the differentiation of Th1 and Th17 cells via an mTORC1-dependent pathway

“…Colitis was induced in mice by DSS as previously described [17]. Arctigenin (25,50 mg/kg) was orally administered daily for 10 days.…”

“…In our previous studies, the ethanol extract of ALF was shown to attenuate dextran sulfate sodium (DSS)-induced colitis in mice, and arctigenin (a dibenzylbutyrolactone lignan) rather than arctiin was identified to be the main active ingredient [17]. Arctigenin was able to inhibit the expressions of several inflammation-related genes in colon tissues, including TNF-α, IL-6, MIP-2, MCP-1, MAdCAM-1 and VCAM-1, with an efficacy comparable or even superior to that of mesalazine (a first-line drug for UC).…”