Ardeemins and citrinin dimer derivatives from Aspergillus terreus harbored in Pinellia ternate

Gu, Liang; Sun, Fu–Juan; Li, Cuiping; Cui, Letian; Yang, Ming‐Hua; Kong, Ling‐Yi

doi:10.1016/j.phytol.2021.02.007

Cited by 5 publications

(4 citation statements)

References 20 publications

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“…Aspergillus sp. [ 17 – 19 , 33 ], Chaetomium globosum [ 34 ], and Stachybotrys chartarum [ 35 ] were reported to have been isolated from P. ternata . Among them, C. globosum and S. chartarum were different from the fungi isolated in this study.…”

Section: Discussionmentioning

confidence: 99%

Diversity, antibacterial and phytotoxic activities of culturable endophytic fungi from Pinellia pedatisecta and Pinellia ternata

et al. 2023

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Background Endophytic fungi of medicinal plants, as special microorganisms, are important sources of antibacterial compounds. However, the diversity and antibacterial activity of endophytic fungi from Pinellia Tenore have not been systematically studied. Results A total of 77 fungi were isolated from roots, stems, leaves, and tubers of Pinellia ternata and P. pedatisecta. All fungi were belonged to five classes and twenty-five different genera. Biological activities tests indicated that 21 extracts of endophytic fungi exhibited antibacterial activities against at least one of the tested bacteria, and 22 fermentation broth of endophytic fungi showed strong phytotoxic activity against Echinochloa crusgalli with the inhibition rate of 100%. Furthermore, four compounds, including alternariol monomethyl ether (1), alternariol (2), dehydroaltenusin (3) and altertoxin II (4), and three compounds, including terreic acid (5), terremutin (6), citrinin (7), were isolated from Alternaria angustiovoidea PT09 of P. ternata and Aspergillus floccosus PP39 of P. pedatisecta, respectively. Compound 5 exhibited strong antibacterial activities against Escherichia coli, Micrococcus tetragenus, Staphylococcus aureus, and Pseudomonas syringae pv. actinidiae with the inhibition zone diameter (IZD) of 36.0, 31.0, 33.7, 40.2 mm and minimum inhibitory concentration (MIC) values of 1.56, 3.13, 1.56, 1.56 μg/mL respectively, which were better than or equal to those of positive gentamicin sulfate. The metabolite 7 also exhibited strong antibacterial activity against P. syringae pv. actinidiae with the IZD of 26.0 mm and MIC value of 6.25 μg/mL. In addition, the compound 7 had potent phytotoxic activity against E. crusgalli with the inhibition rate of 73.4% at the concentration of 100 μg/mL. Conclusions Hence, this study showed that endophytic fungi of P. ternata and P. pedatisecta held promise for the development of new antibiotic and herbicide resources.

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Section: Discussionmentioning

confidence: 99%

Diversity, antibacterial and phytotoxic activities of culturable endophytic fungi from Pinellia pedatisecta and Pinellia ternata

et al. 2023

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“…The marine-derived fungus Aspergillus falconensis yielded five mitorubrins derivative azaphilones with different benzoyl moieties: two new chlorinated azaphilones, falconensins O and P (19 and 20) when the fungus was cultivated in a solid rice medium containing 3.5% NaCl and three additional new azaphilone derivatives (21)(22)(23) when NaCl was replaced by 3.5% NaBr [35]. From the endophytic Aspergillus terreus of Pinellia ternate, the undescribed dimer of citrinin penicitrinol Q (24) was isolated displaying accentuated Gram-positive antibacterial activity [36].…”

Section: Azaphilones From Aspergillus Genusmentioning

confidence: 99%

“…Two dimeric azaphilones, penicitrinol Q ( 24 ) and penctrimertone ( 80 ), showed both excellent inhibitory activities against B. subtilis with MIC of 6.2 and 4.0 µg/mL, respectively. Moreover, ( 24 ) also presented inhibitory activity against bacteria Staphylococcus aureus (4.3 µg/mL) and Pseudomonas aeruginosa (11.2 µg/mL), and the yeast C. albicans (4.0 µg/mL) [ 36 ].…”

Section: Chemistry Biological Activities and Biosynthetic Pathways Of Recently (2020–2021) Reported Azaphilonesmentioning

confidence: 99%

“… Chemical structures of Aspergillus azaphilones 1–2 : sassafrin E-F; 3 : sassafrinamine A; 4 : trans -cavernamine; 5 : cis -cavernamine; 6–10 : Leu, His, Val, Arg, Trp-cavernamine derivatives; 11 : hydroxy-cavernamines; 12–16 : Leu, His, Val, Arg and Trp-hydroxy-cavernamines. ; 17 : cis -cavernine; 18 : trans -cavernine; 19–20 : falconensins O and P; 21–23 : falconensins Q, R, and S; 24 : penicitrinol Q [ 33 , 34 , 35 , 36 ]. …”

Section: Figurementioning

confidence: 99%

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Recent Findings in Azaphilone Pigments

Pimenta

Gomes

Cardoso

et al. 2021

JoF

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Filamentous fungi are known to biosynthesize an extraordinary range of azaphilones pigments with structural diversity and advantages over vegetal-derived colored natural products such agile and simple cultivation in the lab, acceptance of low-cost substrates, speed yield improvement, and ease of downstream processing. Modern genetic engineering allows industrial production, providing pigments with higher thermostability, water-solubility, and promising bioactivities combined with ecological functions. This review, covering the literature from 2020 onwards, focuses on the state-of-the-art of azaphilone dyes, the global market scenario, new compounds isolated in the period with respective biological activities, and biosynthetic pathways. Furthermore, we discussed the innovations of azaphilone cultivation and extraction techniques, as well as in yield improvement and scale-up. Potential applications in the food, cosmetic, pharmaceutical, and textile industries were also explored.

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Aromatic polyketide aspergillones A-D from the endophytic fungus Aspergillus sclerotiorum

Zheng

Zhou

et al. 2023

Phytochemistry Letters

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Ardeemins and citrinin dimer derivatives from Aspergillus terreus harbored in Pinellia ternate

Cited by 5 publications

References 20 publications

Diversity, antibacterial and phytotoxic activities of culturable endophytic fungi from Pinellia pedatisecta and Pinellia ternata

Diversity, antibacterial and phytotoxic activities of culturable endophytic fungi from Pinellia pedatisecta and Pinellia ternata

Recent Findings in Azaphilone Pigments

Aromatic polyketide aspergillones A-D from the endophytic fungus Aspergillus sclerotiorum

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