Are all melanomas the same?

Lee, David A.; Cohen, Jonah N.; Twaddell, William S.; Palacios, Gustavo; Gill, Melissa; Levit, Eyal; Halperin, Alan J.; Mones, Joan M.; Busam, Klaus J.; Silvers, David N.; Çelebi, Jülide Tok

doi:10.1002/cncr.21686

Cited by 41 publications

(3 citation statements)

References 34 publications

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“…HRAS is rarely mutated in malignant melanoma (1, 8, 9). Though the detection of B-RAF gene mutation was recently studied, Lee et al (6) have suggested that in contrast to the majority of cutaneous melanomas, activating hot-spot mutations in B-RAF or N-RAS were not involved in the pathogenesis of spitzoid melanoma. In our case, the mutation of B-RAF gene was negative.…”

Section: Discussionmentioning

confidence: 99%

“…Although spitzoid melanomas are more common in adults, due to extremely low rates of other cutaneous melanoma subtypes in children under the age of 17 yr, the incidence rate appears disproportionately higher in this age group (1, 4, 5). Consequently, there often are spitzoid melanomas originally diagnosed as spitz nevi that metastasize and lead to fatal outcomes in children (6). …”

Section: Introductionmentioning

confidence: 99%

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A Case of Spitzoid Melanoma with Lymph Node Metastasis in a Child

et al. 2012

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The distinction of a spitz nevus from a melanoma can be difficult and in some cases, impossible. A misdiagnosed spitz nevus can metastasize and lead to fatal outcomes, especially in children. A 5-yr-old girl presented with a 1-yr history of a solitary pinkish nodule on her left hand. On physical examination, she had a palpable left axillary lymph node. We performed biopsy and checked 3 sentinel lymph nodes (SLN) on her axillary area. The biopsy specimen showed multiple variably sized and shaped nests with large spindle or polygonal cells and SLN biopsy showed 3 of 3 lymph nodes that were metastasized. Under the diagnosis of spitzoid melanoma, she was treated with excision biopsy and complete left axillary lymph nodes were dissected. She received interferon-α2b subcutaneously at a dose of 8 MIU per day, 3 times weekly for 12 months, and shows no recurrence.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Case of Spitzoid Melanoma with Lymph Node Metastasis in a Child

et al. 2012

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“…16 Furthermore, activating hotspot mutations in the B-RAF, N-RAS, and H-RAS genes were not identified in SMM or SN. 17, 18 This data suggests that SMM might be a distinct form of melanoma with unknown genes and/or signaling pathways involved in its development. 17, 19, 20 …”

Section: Introductionmentioning

confidence: 88%

Imaging Mass Spectrometry—A New and Promising Method to Differentiate Spitz Nevi From Spitzoid Malignant Melanomas

Lazova

Seeley²,

Keenan³

et al. 2012

The American Journal of Dermatopathology

105

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Background Differentiating Spitz nevus (SN) from Spitzoid malignant melanoma (SMM) is one the most difficult problems in Dermatopathology. Specific Aim To identify differences on proteomic level between SN and SMM. Methods We performed Imaging Mass Spectrometry (IMS) analysis on formalin-fixed, paraffin embedded tissue samples (FFPE) to identify differences on proteomic level between SN and SMM. The diagnosis of SN and SMM was based on histopathologic criteria, clinical features, and follow up data, which confirmed that none of the lesions diagnosed as SN recurred or metastasized. The melanocytic component (tumor) and tumor microenvironment (dermis) from 114 cases of SN and SMM from the Yale Spitzoid Neoplasm Repository were analyzed. After obtaining mass spectra from each sample, classification models were built using a training set of biopsies from 26 SN and 25 SMM separately for tumor and for dermis. The classification algorithms developed on the training data set were validated on another set of 30 samples from SN and 33 from SMM. Results We found proteomic differences between the melanocytic components of SN and SMM and identified five peptides that were differentially expressed in the two groups. From these data, 29 out of 30 SN and 26 out of 29 SMM were recognized correctly based on tumor analysis in the validation set. This method correctly classified SN with 97% sensitivity and 90% specificity in the validation cohort. Conclusions IMS analysis can reliably differentiate SN from SMM in FFPE tissue based on proteomic differences.

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Influence of age on survival in childhood spitzoid melanomas

Pol-Rodriquez

Lee

Silvers

et al. 2007

Cancer

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BACKGROUND. Melanoma occurring during childhood and adolescence is rare. Although a few limited studies suggest that the prognosis of childhood melanomas is similar to those in adults, and is dependent on the initial stage of the tumor, there is controversy with respect to the biologic behavior of childhood melanomas. Spitzoid melanoma is a subtype of melanoma with distinct clinical and histopathologic features. The prognosis of spitzoid melanoma in children, despite metastasis, has been suggested to be better than that observed in adults; however, this assertion remains controversial. Whereas a number of spitzoid melanomas with regional lymph node metastasis with no further progression have been reported, cases leading to widespread metastasis and fatal outcomes are also well documented. METHODS. A retrospective review of the literature was conducted between 1949 and 2006. A total of 82 cases of spitzoid melanoma with regional and/or widespread metastasis that occurred in children, 17 years of age and under, were selected for the analysis. RESULTS. The 5‐year survival rate in children diagnosed with metastatic spitzoid melanomas between 0 and 10 years of age was 88% compared with 49% in those between 11 and 17 years of age. CONCLUSIONS. The findings support the notion that younger age (≤10) may be associated with longer survival in children with metastatic spitzoid melanomas. Cancer 2007. © 2007 American Cancer Society.

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Are all melanomas the same?

Cited by 41 publications

References 34 publications

A Case of Spitzoid Melanoma with Lymph Node Metastasis in a Child

A Case of Spitzoid Melanoma with Lymph Node Metastasis in a Child

Imaging Mass Spectrometry—A New and Promising Method to Differentiate Spitz Nevi From Spitzoid Malignant Melanomas

Influence of age on survival in childhood spitzoid melanomas

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