Are allergic reactions to indocyanine green really that uncommon? A single institution experiences

Papadia, Andrea; Gasparri, Maria Luisa; Mueller, Michael D.

doi:10.15761/ogr.1000111

Cited by 10 publications

(9 citation statements)

References 16 publications

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“…On the other hand, SLN in open surgery has been largely described with the use of other tracers such as blue dye, radioactive tracer (technetium) or combined technique (Silva 2005 ; Wydra 2006 ; Altgassen 2007 ; Kara 2008 ; Dostalek 2020 ). Nevertheless, ICG shows some advantages compared to other tracers: the low-risk of allergic reaction compared to blue dye (Papadia 2017 ); possibility of performing SLN biopsy in one-step at the time of surgery and the absence of patients exposure to ionizing radiation compared to radioactive tracer; lastly, it allows a real-time visualization of lymphatic channels.…”

Section: Discussionmentioning

confidence: 99%

Sentinel lymph node mapping with indocyanine green in cervical cancer patients undergoing open radical hysterectomy: a single-institution series

Bizzarri

Anchora

Ferrandina

et al. 2020

J Cancer Res Clin Oncol

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Purpose To assess the rate of bilateral sentinel lymph node (SLN) detection with indocyanine green (ICG), to evaluate the sensitivity and the negative predictive value of cervical cancer patients undergoing open radical hysterectomy; to compare open versus minimally invasive SLN biopsy performance and to assess factors related to no/unilateral SLN mapping. Methods We retrospectively reviewed consecutive patients with FIGO 2018 stage IA1 with lymph-vascular space involvement to IIB and IIIC1p cervical carcinoma who underwent SLN mapping with ICG followed by systematic pelvic lymphadenectomy between 05/2017 and 06/2020. Patients were divided according to surgical approach for statistical analysis. Results Eighty-five patients met inclusion criteria. Twenty-seven (31.8%) underwent open and 58 (68.2%) underwent minimally invasive SLN mapping. No difference in any SLN mapping (laparotomy 92.6% and minimally invasive 91.4%) or in SLN bilateral detection (laparotomy 72.0% and minimally invasive 84.9%) (p = 0.850 and p = 0.222, respectively), in median number of SLNs mapped and retrieved (2 in both groups, p = 0.165) and in site of SLN mapping per hemi-pelvis (right side, p = 0273 and left side, p = 0.618) was evident between open and minimally invasive approach. Per-patient sensitivity of SLN biopsy in laparotomy was 83.3% (95% CI 35.9–99.6%) and the negative predictive value was 95.0% (95% CI 76.0–99.1%). No difference in per-patient sensitivity was noted between two approaches (p = 0.300). None of the analyzed variables was associated with no/unilateral SLN mapping. Conclusion The use of ICG to detect SLN in cervical cancer treated with open surgery allows a bilateral detection, sensitivity and negative predictive value comparable to minimally invasive surgery with potential advantages of ICG compared to other tracers.

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Section: Discussionmentioning

confidence: 99%

Sentinel lymph node mapping with indocyanine green in cervical cancer patients undergoing open radical hysterectomy: a single-institution series

Bizzarri

Anchora

Ferrandina

et al. 2020

J Cancer Res Clin Oncol

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“…Firstly, non-specific probes demonstrate enhanced microcirculation, and ICG is the only Food and Drug Administration approved fluorescent dye. ICG was created by the film company Kodak in the 1950s and was approved for use in human medicine in 1956 (182).…”

Section: Measurement Propertiesmentioning

confidence: 99%

“…ICG has been applied in several medical fields, from the visualization of microcirculation in surgery (184), chorioretinal angiography in ophthalmology (185,186), and liver cancer assessment (187). Allergic reactions are rare, and it has a well-established safety profile (182,188,189). The main caveat for ICG is its limited fluorescent efficiency.…”

Section: Measurement Propertiesmentioning

confidence: 99%

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Associations between fluorescence optical imaging and magnetic resonance imaging and symptoms in hand osteoarthritis

Maugesten

Ohrndorf

Slatkowsky-Christensen

et al. 2021

Rheumatology

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Objectives To investigate whether Fluorescence Optical Imaging (FOI) enhancement and Magnetic Resonance Imaging (MRI)-defined synovitis are associated with pain and physical function in hand osteoarthritis (OA) patients. Methods Bilateral FOI scans and MRI of the dominant hand were available for 221 patients. Finger joints were examined for tenderness on palpation. Pain in individual finger joints during the last 24 h and last 6 weeks and hand pain intensity by the Australian/Canadian hand index and Numeric Rating Scale were self-reported. On joint level, we applied logistic regression with generalized estimating equations to examine whether FOI enhancement and MRI-defined synovitis were associated with pain in the same joint. On subject level, we applied linear regression to assess whether FOI and MRI sum scores were associated with pain intensity and physical function. Results Metacarpophalangeal and thumb base joints were excluded from analyses due to little/no FOI enhancement. Finger joints with FOI enhancement on the composite image had higher odds (95% confidence interval) of pain during the last 6 weeks (grade 1: 1.4 (1.2–1.6), grade 2–3: 2.1 (1.7–2.6)). Similar results were found for joint pain during the last 24 h and joint tenderness in fingers. Numerically stronger associations were found between MRI-defined synovitis and finger joint pain/tenderness. FOI and MRI sum scores demonstrated no/weak associations with hand pain and physical function. Conclusion FOI enhancement and MRI-defined synovitis were associated with pain in the same finger joint. None of the imaging modalities demonstrated consistent associations with pain, stiffness and physical function on subject level.

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“…ICG is considered to be a safe tracer, it should, however, be avoided in patients with iodine allergies as it contains iodine. Allergic reactions to ICG have been described even in the absence of iodine allergy (Papadia et al 2017b). ICG has been injected both intracervically and peritumorally under hysteroscopic guidance (Papadia et al 2017c;Ditto et al 2015).…”

Section: Tracersmentioning

confidence: 99%

Surgical staging in endometrial cancer

Gasparri

Caserta

Panici

et al. 2018

J Cancer Res Clin Oncol

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In several malignancies, it has been demonstrated that the lymph nodal status is the most important pathologic factor affecting prognosis and giving the indication to further adjuvant treatment. The surgical assessment of the lymph nodal status in endometrial cancer is debated since 30 years. Recently, the sentinel lymph node mapping is rapidly gaining clinical acceptance in endometrial cancer. The adoption of Indocyanine Green as a safe and user friendly tracer for sentinel lymph node mapping increased the speed to which this procedure is getting applied in clinical practice. As a consequence of this rapid growth, several fundamental questions have been raised and are still debatable. In this manuscript, we discuss the importance of a known pathological lymph nodal status, the technique of the sentinel lymph node mapping with the reported false negative rates and detection rates according to the different tracers adopted, and the clinical scenarios in which a sentinel lymph node mapping could be employed.

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Are allergic reactions to indocyanine green really that uncommon? A single institution experiences

Cited by 10 publications

References 16 publications

Sentinel lymph node mapping with indocyanine green in cervical cancer patients undergoing open radical hysterectomy: a single-institution series

Sentinel lymph node mapping with indocyanine green in cervical cancer patients undergoing open radical hysterectomy: a single-institution series

Associations between fluorescence optical imaging and magnetic resonance imaging and symptoms in hand osteoarthritis

Surgical staging in endometrial cancer

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