Are antioxidant enzymes essential markers in the diagnosis and monitoring of cancer patients – A review

Cecerska-Heryć, Elżbieta; Surowska, Oliwia; Heryć, Rafał; Serwin, Natalia; Napiontek-Balińska, Sylwia; Dołęgowska, Barbara

doi:10.1016/j.clinbiochem.2021.03.008

Cited by 79 publications

(52 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CAT is an ubiquitous enzyme that physiologically catalyzes the decomposition of H2O2 to water and oxygen: CAT protects cells from excessive ROS production, thus preventing H2O2 accumulation. In many tumors, a decreased CAT expression and activity have been reported [ 34 ]: an altered CAT expression has been widely demonstrated in association with different types of cancers compared to their normal counterparts, as reported by some authors, who have shown an increased expression of CAT in tumors [ 39 ]. The regulation of CAT expression in cancer cells is a complex process, where various mechanisms appear to be involved: a recent review [ 40 ] explored these different crucial mechanisms in the CAT regulation, mainly via Akt/PKB in the PI3K signaling pathway in cancer cells.…”

Section: Oxidative Stress In Cancer Metabolismmentioning

confidence: 99%

“…Among the main enzymes involved in antioxidant cellular defense, SOD, which is dependent on metal ions, is essential. SOD protects cells from oxidizing toxic products produced during aerobic respiration; this enzyme is involved in the conversion of superoxide radicals into oxygen and it has been shown that some defects in SOD activity are related to various cancers [ 34 ], although these data are often contradictory with each other; reduced SOD activity has been observed in brain tumor patients compared to normal subjects, while high SOD levels have been demonstrated to be associated with other cancers, such as breast and laryngeal carcinomas [ 35 ]. In general, reduced SOD activity is often associated with an increase in intracellular H2O2 levels, which would first favor DNA damage and consequently cancer development [ 36 ].…”

Section: Oxidative Stress In Cancer Metabolismmentioning

confidence: 99%

See 1 more Smart Citation

Transforming Growth Factor-β and Oxidative Stress in Cancer: A Crosstalk in Driving Tumor Transformation

Ramundo

Giribaldi

Aldieri

2021

Cancers

View full text Add to dashboard Cite

Cancer metabolism involves different changes at a cellular level, and altered metabolic pathways have been demonstrated to be heavily involved in tumorigenesis and invasiveness. A crucial role for oxidative stress in cancer initiation and progression has been demonstrated; redox imbalance, due to aberrant reactive oxygen species (ROS) production or deregulated efficacy of antioxidant systems (superoxide dismutase, catalase, GSH), contributes to tumor initiation and progression of several types of cancer. ROS may modulate cancer cell metabolism by acting as secondary messengers in the signaling pathways (NF-kB, HIF-1α) involved in cellular proliferation and metastasis. It is known that ROS mediate many of the effects of transforming growth factor β (TGF-β), a key cytokine central in tumorigenesis and cancer progression, which in turn can modulate ROS production and the related antioxidant system activity. Thus, ROS synergize with TGF-β in cancer cell metabolism by increasing the redox imbalance in cancer cells and by inducing the epithelial mesenchymal transition (EMT), a crucial event associated with tumor invasiveness and metastases. Taken as a whole, this review is addressed to better understanding this crosstalk between TGF-β and oxidative stress in cancer cell metabolism, in the attempt to improve the pharmacological and therapeutic approach against cancer.

show abstract

Section: Oxidative Stress In Cancer Metabolismmentioning

confidence: 99%

Section: Oxidative Stress In Cancer Metabolismmentioning

confidence: 99%

Transforming Growth Factor-β and Oxidative Stress in Cancer: A Crosstalk in Driving Tumor Transformation

Ramundo

Giribaldi

Aldieri

2021

Cancers

View full text Add to dashboard Cite

show abstract

“…XOR, CAT, SOD, and GPx expression is decreased in patients with ovarian cancer. Colorectal cancer is characterized by increased MnSOD expression (in vitro studies) and SOD expression while CAT, GPx, and GR are decreased (in vivo study); and finally, (iii) SOD, CAT, and XOR are proposed as prognostic markers in cancer of the lung, bladder, ovarian, and colon [81]. Moreover, antioxidants can also be chemically synthesized, such as N-acetyl cysteine (NAC), pyruvate, selenium, butylated hydroxytoluene (BHT), butylated hydroxyanisole (BHA), and propyl gallate [82].…”

Section: Antioxidants As a Defense Mechanism Against Oxidative Stressmentioning

confidence: 99%

Halophilic Carotenoids and Breast Cancer: From Salt Marshes to Biomedicine

Giani

Montoyo-Pujol²,

Peiró³

et al. 2021

Marine Drugs

View full text Add to dashboard Cite

Breast cancer is the leading cause of death among women worldwide. Over the years, oxidative stress has been linked to the onset and progression of cancer. In addition to the classical histological classification, breast carcinomas are classified into phenotypes according to hormone receptors (estrogen receptor—RE—/progesterone receptor—PR) and growth factor receptor (human epidermal growth factor receptor—HER2) expression. Luminal tumors (ER/PR-positive/HER2-negative) are present in older patients with a better outcome. However, patients with HER2-positive or triple-negative breast cancer (TNBC) (ER/PR/HER2-negative) subtypes still represent highly aggressive behavior, metastasis, poor prognosis, and drug resistance. Therefore, new alternative therapies have become an urgent clinical need. In recent years, anticancer agents based on natural products have been receiving huge interest. In particular, carotenoids are natural compounds present in fruits and vegetables, but algae, bacteria, and archaea also produce them. The antioxidant properties of carotenoids have been studied during the last years due to their potential in preventing and treating multiple diseases, including cancer. Although the effect of carotenoids on breast cancer during in vitro and in vivo studies is promising, clinical trials are still inconclusive. The haloarchaeal carotenoid bacterioruberin holds great promise to the future of biomedicine due to its particular structure, and antioxidant activity. However, much work remains to be performed to draw firm conclusions. This review summarizes the current knowledge on pre-clinical and clinical analysis on the use of carotenoids as chemopreventive and chemotherapeutic agents in breast cancer, highlighting the most recent results regarding the use of bacterioruberin from haloarchaea.

show abstract

“…Oxidation is an important process for the energy productive of many biological organs [50]. Studies have shown that cancer, inflammation, blood diseases, and other diseases are closely related to oxidative free radicals, and excessive free radicals in the human body will lead to aging [51][52][53]. Commonly, antioxidant capacity can be assessed by in vivo and in vitro methods [54].…”

Section: Antioxidant Activities Of 21 Batches Of Saffronmentioning

confidence: 99%

Multivariate Statistical Analysis Uncovers Spectrum–Effect Relationship between HPLC Fingerprints and Antioxidant Activity of Saffron

You

Zhong

et al. 2021

Journal of Chemistry

View full text Add to dashboard Cite

Crocus sativus L. is commonly used as functional food and medicinal herb in traditional Chinese medicine. In this study, the spectrum–effect relationship was established between HPLC fingerprints and in vitro antioxidant activity of saffron to improve the quality evaluation method of saffron. The fingerprints of 21 batches of saffron collected from different regions were assessed, and the data were further analyzed by chemometric methods, including similarity analysis, hierarchical clustering analysis, principal component analysis, and orthogonal partial least squares discriminant analysis. The spectrum–effect relationship between fingerprints and antioxidant effect of saffron was analyzed by grey relational analysis and partial least square methods to figure out the antioxidant component of saffron. Thirteen common peaks of 21 batches of saffron were included in the analysis, and peak 3 (picrocrocin), peak 7 (crocin I), and peak 10 (crocin II) were identified as the main active components responsible for antioxidant efficacy. Besides, a multi-index quality control method was developed for simultaneous determination of these three antioxidant components in saffron. Taken together, this study provided new strategies for the quality control and the development of new bioactive products of saffron in the future.

show abstract

Are antioxidant enzymes essential markers in the diagnosis and monitoring of cancer patients – A review

Cited by 79 publications

References 36 publications

Transforming Growth Factor-β and Oxidative Stress in Cancer: A Crosstalk in Driving Tumor Transformation

Transforming Growth Factor-β and Oxidative Stress in Cancer: A Crosstalk in Driving Tumor Transformation

Halophilic Carotenoids and Breast Cancer: From Salt Marshes to Biomedicine

Multivariate Statistical Analysis Uncovers Spectrum–Effect Relationship between HPLC Fingerprints and Antioxidant Activity of Saffron

Contact Info

Product

Resources

About