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Purpose of review The purpose of this review is to provide a comprehensive update of literature published between January 2018 and April 2024, examining suicidal thoughts and behavior (STB) prevalence, risk factors, theoretical models, and interventions in autism. Recent findings We identified four recent meta-analyses and two systematic reviews. Pooled prevalence estimates in autism ranged from 34.2% for suicide ideation to 24.3% for suicide attempts. Autistic traits, interpersonal factors, and depressive symptoms were identified as STB risk factors, with elevated risk observed across the lifespan. Summary We included 80 studies examining STB in diagnosed autistic people or autistic traits in non-clinical samples. Autistic people were found to have an up to eightfold increased risk of death by suicide compared to non-autistic people, although reported rates varied considerably between studies; co-occurring mental health conditions, social, psychological, and cognitive factors exacerbated risk. Validated STB assessment tools and interventions for autistic people were notably scarce.
Purpose of review The purpose of this review is to provide a comprehensive update of literature published between January 2018 and April 2024, examining suicidal thoughts and behavior (STB) prevalence, risk factors, theoretical models, and interventions in autism. Recent findings We identified four recent meta-analyses and two systematic reviews. Pooled prevalence estimates in autism ranged from 34.2% for suicide ideation to 24.3% for suicide attempts. Autistic traits, interpersonal factors, and depressive symptoms were identified as STB risk factors, with elevated risk observed across the lifespan. Summary We included 80 studies examining STB in diagnosed autistic people or autistic traits in non-clinical samples. Autistic people were found to have an up to eightfold increased risk of death by suicide compared to non-autistic people, although reported rates varied considerably between studies; co-occurring mental health conditions, social, psychological, and cognitive factors exacerbated risk. Validated STB assessment tools and interventions for autistic people were notably scarce.
The increased prevalence of suicide among autistic people highlights the need for validated clinical suicide screening and assessment instruments that are accessible and meet the unique language and communication needs of this population. We describe the preliminary preregistered psychometric validation of the Suicide Assessment Kit-Modified Interview, in a sample of 98 autistic adults (58% women, 34% men, 7% nonbinary; MAGE = 41.65, SD = 12.96). A four-item negative affect score derived from the Suicide Assessment Kit-Modified Interview demonstrated adequate reliability (ω = 0.796, BCa 95% confidence interval = [0.706, 0.857]), as well as good convergent validity with related measures. Ordinal Suicide Assessment Kit-Modified Interview “categories” (1–5) demonstrated divergent validity ( rs = −0.067 to 0.081) and good convergent validity, strongly correlating with mental health ( rs = 0.446 to 0.744) and suicide assessment instruments ( rs = 0.576 to 0.696). Suicide Assessment Kit-Modified Interview categories showed strong ability to predict participants identified by clinicians as “above low risk” of future suicide attempt (area under the curve = 0.887, posterior Mdn = 0.889, 95% credible interval = [0.810, 0.954], PAUC > 0.8 = 0.976). Suicide Assessment Kit-Modified Interview classifications > “Category 3” provided an observed sensitivity of 0.750 ( Mdn = 0.810, [0.669, 0.948], PSe > 0.8 = 0.544) and an observed specificity of 0.895 ( Mdn = 0.899, [0.833, 0.956], PSp > 0.8 = 0.995) for “above low risk” status. Our findings indicate that the Suicide Assessment Kit-Modified Interview is a psychometrically strong clinical assessment tool for suicidal behavior that can be validly administered to autistic adults without intellectual disability. Lay Abstract People with a diagnosis of autism are at increased risk of death by suicide. There is a need for clinical instruments that are adapted to the needs of autistic people. In this study, we modified and evaluated a clinical suicide interview (Suicide Assessment Kit-Modified Interview) for use with autistic people who do not have an intellectual disability. Autistic people helped us to modify the original version of the instrument by improving the questions, providing explanations for difficult terms or concepts, and recommending that we use different rating scales. Our results support the use of Suicide Assessment Kit-Modified Interview for assessing autistic adults without intellectual disability for suicidal thoughts and behavior. In the future, we will test how well Suicide Assessment Kit-Modified Interview works in clinical settings and with different clinical populations.
Despite very high rates of suicidal thoughts and behaviors (STB) in autistic adults, the key psychosocial drivers of this phenomenon remain unknown. To investigate, we examined how lifetime stressor exposure and severity, which have been found to predict STB in non-autistic populations, related to STB in a multinational dataset of 226 autistic adults from the United Kingdom and Australia (67% female; Mage = 41.8, SD = 13.6, range = 19–73 years old). Results revealed that autistic men and women differ with respect to the count, severity, and type of stressors they experienced over the life course. Whereas autistic men were exposed to more numerous legal/crime-related stressors, autistic women experienced more stressors related to social relationships and chronic humiliation and typically experienced stressors as more severe. In addition, whereas chronic interpersonal loss was related to STB for men, acute stressors involving physical danger and lower exposure to chronic entrapment were related to STB in autistic women. These findings indicate that certain lifetime stressors may be differentially experienced, and relevant to STB, in autistic men versus women. They also suggest that screening for lifetime stressor exposure may help identify autistic individuals at greatest risk of suicide. Lay abstract When we encounter life events that we experience as stressful (“stressors”), it sets off a biological stress response that can impact mental health and contribute to suicidal thoughts and behaviors (STB). Although we know about specific stressors that are associated with STB in the general population, little is known about the kinds of stressors that increase the risk of STB in autistic people and whether these associations differ by gender. To examine this issue, we cataloged the life stressors that autistic men and women experienced over the entire life course and investigated how these stressors were related to STB. Data were derived from a multinational sample of 226 autistic adults from the United Kingdom and Australia who completed the Stress and Adversity Inventory for Adults. We found that autistic men and women differed in terms of both the lifetime stressors they experienced as well as their perceived severity. Whereas men experienced more legal/crime-related stressors, women experienced more stressors related to relationships with other people and more long-lasting stressors associated with humiliation. Autistic women often perceived life stressors as more severe than men, which is important given that it is the perceived severity of stressors that most strongly affects our health. We also found that different stressors may predict STB in autistic men versus women. Whereas loss of loved ones was most strongly associated with STB for men, for women, physically dangerous stressors were most relevant. In addition, women with fewer lifetime stressors involving entrapment had higher lifetime STB. These results suggest that lifetime stressor exposure may be important to assess to understand suicide risk in autistic people. Additional research is needed to confirm these associations and to examine possible mechanisms linking stress and STB.
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