Are Capillary DBS Applicable for Therapeutic Drug Monitoring of Common Antipsychotics? A Proof of Concept

Patteet, Lisbeth; Maudens, Kristof E.; Stove, Christophe; Lambert, Willy E.; Morrens, Manuel; Sabbe, Bernard; Neels, Hugo

doi:10.4155/bio.15.100

Cited by 23 publications

(17 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In that study using samples taken from subjects receiving stable doses of their antipsychotics for at least 7 days, concentrations in dried blood spots obtained from finger-stick-based capillary sampling were similar to those in dried blood spots obtained from venous sampling. 16 In the current study, there was a close agreement between the capillary and venous concentrations in plasma: the regression analyses confirmed a linear correlation between (log-transformed) capillary and venous plasma concentrations for all measured parent drugs, metabolites, and sums of parent drug and metabolite. Except for olanzapine, no statistical differences were found between the capillary and venous drug concentrations.…”

Section: Discussionsupporting

confidence: 75%

“…Likewise, in the literature, finger‐stick‐based capillary and venous concentrations were reported to be similar after repeated dosing for a number of antipsychotics16 and for, for example, theophylline,17 cyclosporin,18 and tobramycin 19…”

Section: Discussionmentioning

confidence: 73%

“…In parallel with the study pre-sented here, a similar study was initiated by another group of researchers, the results of which were recently published. 16…”

mentioning

confidence: 99%

See 2 more Smart Citations

Comparison of Capillary and Venous Plasma Drug Concentrations After Repeated Administration of Risperidone, Paliperidone, Quetiapine, Olanzapine, or Aripiprazole

Remmerie

Meulder

Ariyawansa

et al. 2016

Clinical Pharm in Drug Dev

View full text Add to dashboard Cite

Quantification of blood levels of antipsychotic drugs may be useful for managing medication therapy. This open‐label, parallel‐group study was performed to compare finger‐stick‐based capillary with corresponding venous plasma concentrations for risperidone, paliperidone, quetiapine, olanzapine, and aripiprazole and their major metabolites after repeated dosing in patients with schizophrenia or related illnesses. Finger‐stick‐based capillary and venous blood samples were collected at various times within a dosing interval. All drug concentration measurements in the derived plasma samples were performed with validated liquid chromatography–tandem mass spectrometry methods. Finger‐stick‐based capillary and venous plasma drug concentrations after repeated dosing were generally similar. Olanzapine capillary plasma concentrations, however, were on average approximately 20% higher than venous concentrations, with a trend for a relatively greater difference occurring shortly after dosing. In addition, smaller capillary–venous differences were observed for extended‐release and long‐acting intramuscular formulations and for aripiprazole, a drug with a long half‐life, compared with drugs administered as an immediate‐release formulation (risperidone, olanzapine). After repeated dosing, plasma derived from finger‐stick‐based blood was observed to be predictive of the venous concentrations. Capillary sampling may be an appropriate alternative to venous sampling to readily evaluate systemic drug concentrations.

show abstract

Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 73%

See 1 more Smart Citation

Comparison of Capillary and Venous Plasma Drug Concentrations After Repeated Administration of Risperidone, Paliperidone, Quetiapine, Olanzapine, or Aripiprazole

Remmerie

Meulder

Ariyawansa

et al. 2016

Clinical Pharm in Drug Dev

View full text Add to dashboard Cite

show abstract

“…To our knowledge, published results of well-designed studies conducted to evaluate the correlation between capillary and venous concentrations of antipsychotic medications, particularly of risperidone, paliperidone (9-hydroxyrisperidone), quetiapine, olanzapine, aripiprazole, and dehydroaripiprazole, are limited to 1 study comparing capillary and venous concentrations in dried blood spots. 10 However, this study evaluated the correlation under steady-state conditions only. The present study was initiated to compare the capillary and corresponding venous plasma and whole-blood concentrations of these antipsychotics after administration of a single oral dose to healthy participants.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Capillary and Venous Drug Concentrations After Administration of a Single Dose of Risperidone, Paliperidone, Quetiapine, Olanzapine, or Aripiprazole

Remmerie

Meulder

Weiner

et al. 2016

Clinical Pharm in Drug Dev

View full text Add to dashboard Cite

Risperidone, paliperidone, quetiapine, olanzapine, and aripiprazole are antipsychotic drugs approved for treating various psychiatric disorders, including schizophrenia. The objective of this randomized, parallel‐group, open‐label study was to compare finger‐stick‐based capillary with corresponding venous whole‐blood and plasma concentrations for these drugs after administration of a single dose to healthy volunteers. All whole‐blood and plasma drug concentrations were measured with validated liquid chromatography–tandem mass spectrometry methods. Capillary and venous concentrations (both in plasma and whole blood) were in close agreement, although a time‐dependent difference was observed, most obviously for olanzapine and paliperidone, with slightly higher capillary versus venous drug concentrations during the first hours after administering a single dose. The observed difference between capillary and venous plasma drug concentrations is expected not to be relevant in clinical practice, considering the wide window of therapeutic concentrations and the wide range of drug concentrations in the patient population for a given dose. Based on these results, finger‐stick‐based capillary drug concentrations have been shown to approximate venous drug concentrations.

show abstract

“…Another practical issue in interpreting DBS results is the fact that existing reference intervals and therapeutic ranges are generally established using serum or plasma. So either new reference intervals need to be set up for the specific matrix or bridging studies have to be conducted to correlate alternative matrix levels to systemic plasma or serum levels, whenever a correlation between both is assumed 117 . However, thorough clinical validation is often lacking, as generally only a limited number of samples are included in these studies or the included samples are not true patient samples.…”

Section: Limiting Factorsmentioning

confidence: 99%

Opening the toolbox of alternative sampling strategies in clinical routine: A key-role for (LC-)MS/MS

Velghe

Capiau

Stove

2016

TrAC Trends in Analytical Chemistry

View full text Add to dashboard Cite

Alternative sampling strategies such as dried blood sampling, liquid microsampling and the sampling of oral fluid, hair, meconium, interstitial fluid, sweat, exhaled breath condensate and sputum offer interesting opportunities for many applications in clinical routine. Here, we provide an overview of different applications, with special attention to the pivotal role of LC-MS/MS in facilitating analysis of the collected matrices. Covered clinical fields include newborn screening, endocrinology, therapeutic drug monitoring, phenotyping, toxicology, proteomics and metabolomics. Furthermore, specific advantages, challenges and limitations of each alternative sampling strategy are discussed, along with recent advances and future trends that may contribute to routine implementation of these sampling strategies. Given the development of many recent potentially valuable clinical applications, the possibility of home sampling and the opportunity to obtain information that is hard to procure using traditional sampling, a well-balanced role for alternative sampling strategies can be envisaged in patient healthcare in the (near) future.

show abstract

Are Capillary DBS Applicable for Therapeutic Drug Monitoring of Common Antipsychotics? A Proof of Concept

Cited by 23 publications

References 29 publications

Comparison of Capillary and Venous Plasma Drug Concentrations After Repeated Administration of Risperidone, Paliperidone, Quetiapine, Olanzapine, or Aripiprazole

Comparison of Capillary and Venous Plasma Drug Concentrations After Repeated Administration of Risperidone, Paliperidone, Quetiapine, Olanzapine, or Aripiprazole

Comparison of Capillary and Venous Drug Concentrations After Administration of a Single Dose of Risperidone, Paliperidone, Quetiapine, Olanzapine, or Aripiprazole

Opening the toolbox of alternative sampling strategies in clinical routine: A key-role for (LC-)MS/MS

Contact Info

Product

Resources

About