Are children with attention-deficit/
hyperactivity disorder (ADHD) more
likely to develop celiac disease?
A prospective study

Mohammadi, Mohammad Hasan; Hesaraki, Mehran

doi:10.5114/ppn.2023.127573

Cited by 3 publications

(2 citation statements)

References 29 publications

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“…For instance, in the case of CeD, diagnostic information encompassed not only clinical s y m p t o m a t o l o g y a n d s e r o l o g i c a l m a r k e r s b u t a l s o histopathological identification (24,26). On the other hand, some past studies might have just used quick diagnostic tests for CeD in the absence of such thorough diagnostic protocols (57,58).…”

Section: Discussionmentioning

confidence: 99%

“…(iv) The disparities in our study findings compared to previous research linking CeD and ADHD may stem from differences in population inclusion and diagnostic criteria for the disease. Our study encompassed a broad spectrum of European countries, incorporating various European ethnic groups, whereas previous studies often focused on large cohorts within a single country or non-European populations ( 17 , 18 , 57 ). Furthermore, the GWAS database we used for our research followed strict guidelines for selecting case samples.…”

Section: Discussionmentioning

confidence: 99%

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Celiac disease and attention-deficit/hyperactivity disorder: a bidirectional Mendelian randomization analysis

Chen,

Zhu,

et al. 2024

Front. Psychiatry

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BackgroundRecent observational research suggests a potential link between celiac disease (CeD) and an increased incidence of attention-deficit/hyperactivity disorder (ADHD). However, the genetic relationship between CeD and ADHD remains unclear. In order to assess the potential genetic causality between these two conditions, we conducted a Mendelian randomization (MR) analysis.MethodsWe performed a bidirectional MR analysis to investigate the relationship between CeD and ADHD. We carefully selected single nucleotide polymorphisms (SNPs) from publicly available large-scale genome-wide association studies (GWAS) databases, employing rigorous quality screening criteria. MR estimates were obtained using four different methods: fixed-effect inverse variance weighted (fe-IVW), random-effect inverse variance weighting (re-IVW), weighted median (WM), and MR-Egger. The robustness and reliability of our findings were confirmed through sensitivity analyses, assessment of instrumental variable (IV) strength (F-statistic), and statistical power calculations.ResultsOur MR analyses did not reveal any significant genetic associations between CeD and ADHD (fe-IVW: OR = 1.003, 95% CI = 0.932–1.079, P = 0.934). Similarly, in the reverse direction analysis, we found no evidence supporting a genetic relationship between ADHD and CeD (fe-IVW: OR = 0.850, 95% CI = 0.591–1.221, P = 0.378). Various MR approaches consistently yielded similar results. Sensitivity analysis indicated the absence of significant horizontal pleiotropy or heterogeneity. However, it’s important to note that the limited statistical power of our study may have constrained the causal analysis of the exposure’s influence on the outcome.ConclusionsOur findings do not provide compelling evidence for a genetic association between CeD and ADHD within the European population. While the statistical power of our study was limited, future MR research could benefit from larger-scale datasets or datasets involving similar traits. To validate our results in real-world scenarios, further mechanistic studies, large-sample investigations, multicenter collaborations, and longitudinal studies are warranted.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Celiac disease and attention-deficit/hyperactivity disorder: a bidirectional Mendelian randomization analysis

Chen,

Zhu,

et al. 2024

Front. Psychiatry

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Psychometric Properties of the Arabic Vanderbilt Children's ADHD Diagnostic Rating Scale (VADRS-A) in a Saudi Population Sample

Alqahtani,

Al Saud,

Alsharef

et al. 2024

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology

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Objective This study aimed to utilize Principal Component Analysis (PCA) and Confirmatory Factor Analysis (CFA) to investigate the constructive validity of the Arabic translation of the Vanderbilt Attention Deficit/Hyperactive Disorder (ADHD) Diagnostic Scale (VADRS-A) using its two versions, the Arabic Vanderbilt ADHD Diagnostic Parent Rating Scale (VADPRS-A) and the Arabic Vanderbilt ADHD Diagnostic Teacher Rating Scale (VADTRS-A). Method A descriptive research design was employed. Children were assessed by their parents and teachers, and a cluster sample of 1812 participants was chosen from many schools in Saudi Arabia, divided into two groups: parents (504) and teachers (1308) of children whose ages ranged between 5 to 12 years old. The VADPRS-A and VADTRS-A were administered to parents and teachers under the supervision of the Saudi ADHD Society. Results The results of the PCA of VADPRS-A found that the six factors saturate one general factor that explained (59%) of the total variance of the factor matrix with eigenvalues (3.540). Similarly, the PCA of VADTRS-A demonstrated that the five factors were saturated on a general factor that explained (69.20%) of the total variance of the factor matrix with eigenvalues (3.460). Also, the results indicate the high internal consistency of VADPRS-A and VADTRS-A, all factors correlated together and the total scores positively and significantly statistically (p>.001) correlation coefficients ranged between (0.296 to 0.843) for VADPRS-A, and ranges between (0.432 to 0.939) for VADTRS-A. Also, the Cronbach's α coefficient values for the six factors and total score of VADPRS-A were (.906, .925, .900, .896, .853, .872, .959) respectively, and these values are close to the values of the McDonald's ω for the factors and the total score were (.908, .923, .901, .871, .850, .877, .925) respectively. In the same way, Cronbach's α coefficients were (.967, .921, .914, .858, .948, .971) for all factors and the total score of VADTRS-A respectively, and these values are close to the values of the McDonald's ω (.968, .921, .919, .856, .943, .965) for all factors and the total score of VADTRS-A. In addition CFA for VADPRS-A and VADTRS-A models showed acceptable factor loading and good values of goodness-of-fit indices; CFI, TLI, RMSEA, IFI, and GFI (0.956, 0.942, 0.049, 0.956, 0.952) respectively for VADPRS-A model, and were (0.958, 0.932, 0.051, 0.963, 0.964) for VADTRS-A model, all of these were at an acceptable range. These results suggest a fit with the previous theoretical literature about VADPRS and VADTRS and DSM-5 and ICD-11 criteria of ADHD. Conclusion These findings highlighted the good psychometric properties of VADRS-A in both its versions VADPRS-A and VADTRS-A in the Saudi environment. Due to these findings, we suggest utilizing VADPRS-A and VADTRS-A during ADHD diagnosis in children 5-12 years old in Saudi Arabia, to facilitate early diagnosis and intervention, and to help mitigate the risks of ADHD during subsequent developmental phases in children's lives.

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Çölyak Tanili Bi̇reyleri̇n Motor Beceri̇ Ve Di̇kkat Düzeyleri̇ni̇n Değerlendi̇ri̇lmesi̇- Pi̇lot Çalişma

Ciledag,

Kuş,

Özbay

et al. 2024

İnönü Üniversitesi Sağlık Hizmetleri Meslek Yüksek Okulu Dergisi

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Çölyak hastalığı dünyada yaklaşık %1 oranında görülmektedir. Başta Gastrointestinal Sistem (GİS) problemleri olmak üzere nöroloji, psikiyatri, immünoloji kaynaklı birçok durumla ilişkilendirilmektedir. Sebep olabileceği ekstarintestinal problemler göz önüne alındığında çölyaklı bireylerin motor beceri ve dikkat düzeyleri etkilenmiş olabilir. Araştırmada 22-60 yaş arası ek nörolojik ve ortopedik problemi bulunmayan çölyak ve non çölyaklı bireylerin motor beceri düzeyleri Zamanlı Kalk Yürü ve Zamanlı Merdiven İnip Çıkma Testi ile, dikkat düzeyleri Erişkin Dkkat Eksikliği ve Hiperaktivite Bozukluğu Kendi Bildirim Ölçeği ile değerlendirilmiştir. Motor beceri değerlendirmesinden Merdiven İnip Çıkma Testi istatistiksel olarak anlamlı bulundu (p0.05). Çalışmamıza göre çölyaklı bireylerde motor beceri etkilenimi görülmektedir. İleriki çalışmalarda çölyaklı bireylerin daha büyük örneklem gruplarında ve daha bütüncül olarak değerlendirilmesi gerekmektedir.

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Are children with attention-deficit/ hyperactivity disorder (ADHD) more likely to develop celiac disease? A prospective study

Cited by 3 publications

References 29 publications

Celiac disease and attention-deficit/hyperactivity disorder: a bidirectional Mendelian randomization analysis

Celiac disease and attention-deficit/hyperactivity disorder: a bidirectional Mendelian randomization analysis

Psychometric Properties of the Arabic Vanderbilt Children's ADHD Diagnostic Rating Scale (VADRS-A) in a Saudi Population Sample

Çölyak Tanili Bi̇reyleri̇n Motor Beceri̇ Ve Di̇kkat Düzeyleri̇ni̇n Değerlendi̇ri̇lmesi̇- Pi̇lot Çalişma

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