Are clinical parameters and biomarkers predictive of severity of acute pulmonary emboli on CTPA?

Abstract

These findings suggest that clinical parameters and biomarkers have a role in predicting the radiological severity of PE. These data support the need for further studies of risk stratification in patients presenting with acute PE.

Pulmonary artery obstruction index is not associated with elevated heart-type fatty acid-binding protein and mortality in patients with pulmonary embolism at intermediate risk: short-term mortality results

“…According to Ghaye et al (10) and van der Meer et al (9), RV/LV ratio is a strong predictor of the severity of PE and patient outcome. This is in contrast to the studies of Araoz et al (11) and Jeebun et al (15), in which no association between the RV/LV ratio and death was reported. Similarly, in our study, RV/LV ratio did not predict mortality at 30-day followup.…”

“…The strong correlation between troponin I levels and both PAOI and RV/LV ratio has recently been emphasized by Shokoohi et al (14) and Jeebun et al (15). Consistent with these studies, we also found a significant but low correlation between troponin I levels and both PAOI and RV/LV ratio.…”

Dual energy CT pulmonary blood volume assessment in acute pulmonary embolism – correlation with D-dimer level, right heart strain and clinical outcome

“…The level of d-dimers has been shown to correlate with right heart dysfunction and clot burden as well as to be a negative outcome predictor, since short and long term survival after acute PE is limited with increasing d-dimer levels [25][26][27][28][29][30]. However, keeping in mind the low specificity of this test, the mean d-dimer level was also slightly elevated in the control group without PE, but it was significantly lower than in patients with PE.…”

Computed tomography to assess risk of death in acute pulmonary embolism: a meta-analysis

“…15 studies were initially excluded [10,19,20,22,26,31,33,35,38,39,41,43,46,50,52]. For six of them, the inclusion in the analysis was possible following contact with the authors [22,35,38,39,43,52].…”