Are cytokines involved in osteoarthritic pathophysiology?

Pelletier, Jean‐Pierre; Roughley, Peter J.; DiBattista, John A.; McCollum, Robert W.; Martel‐Pelletier, Johanne

doi:10.1016/0049-0172(91)90024-t

Cited by 129 publications

(72 citation statements)

References 94 publications

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“…The uncompensated actions of such a potent cytokine can have deleterious consequences, and indeed IL-1 has been implicated in a wide range of pathological processes including sepsis, septic shock, and inflammatory diseases such as arthritis and periodontitis (2)(3)(4). The cellular responses to IL-1 stimulation are well documented and include increased production of matrix metalloproteinases (5, 6), prostaglandin E 2 (7), and reactive oxygen species (8).…”

Section: Interleukin-1 (Il-1)mentioning

confidence: 99%

Requirements of Focal Adhesions and Calcium Fluxes for Interleukin-1-induced ERK Kinase Activation and c-fos Expression in Fibroblasts

Lo¹,

Luo²,

McCulloch³

et al. 1998

Journal of Biological Chemistry

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Section: Interleukin-1 (Il-1)mentioning

confidence: 99%

Requirements of Focal Adhesions and Calcium Fluxes for Interleukin-1-induced ERK Kinase Activation and c-fos Expression in Fibroblasts

Lo¹,

Luo²,

McCulloch³

et al. 1998

Journal of Biological Chemistry

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“…The synovial inflammatory reaction is responsible for the osteoarthrosis symptoms, thus playing an important part in the pathophysiology by aggravating cartilage metabolism. 31,32 The apparent enlargement of the operated joint was possibly due to the inflammatory response and proliferation of soft tissue vascularity around the bones. Bone scintigraphy with 99 DMPtechnetium performed in the sixth month postoperatively in three beagles demonstrated n.s., not significant.…”

Section: Discussionmentioning

confidence: 99%

“…These enzymes in turn, degrade the cartilage in a perennial cyclic process. 31,32 Experimental [33][34][35][36] and clinical 37,38 trials demonstrated the efficacy of an interleukin-1b inhibitor, diacerein (DAR), in restraining the osteoarthrosic process.…”

Section: Introductionmentioning

confidence: 99%

Effect of oral diacerein (DAR) in an experimental hip chondrolysis model

Kitadai

Takahashi

Straus

et al. 2006

Journal Orthopaedic Research

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We aimed to reproduce the articular cartilage structural changes in a joint exposed to a metallic implant as in the adolescent pinned hip with persistent joint penetration and secondly, to test the effect of an interleukin inhibitor, diacerein (DAR) in the ensuing articular cartilage lesion. Twenty immature beagles were submitted to a surgical K-wire implantation in the hip with the material left in the joint space for 6 months. Twelve animals were sacrificed for histological and biochemical tests. Eight animals were sacrificed at 10 months (half of them treated with DAR) and analyzed by scanning electron microscopy (SEM) and biochemistry of the articular cartilage. Preoperative and monthly C3 and C4 complement and immunoglobulins serum levels were determined. The histological and the electrophoretic profile changes were significative at 6 months. At 10 months the migration profile (CaCl 2 ) recovered to normal levels in the operated hip and the SEM scores for the acetabulum were similar to the non operated control hip after treatment. The serum level of IgA was elevated at the 4th and 6th month postoperatively. The persistence of a metallic implant resulted in degenerative changes parallel to that described for hip chondrolysis as a complication of in-situ pinning; and the cartilage lesion improved with DAR treatment. ß

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“…Interleukin -1 tumour necrosis factor þ are thought to activate enzymes associated with the proteolytic digestion of cartilage [14]. Insulin growth factor 1 and tissue growth factor þ may be involved in cartilage synthesis and repair processes [15].…”

Section: Overviewmentioning

confidence: 99%

Topical diclofenac: clinical effectiveness and current uses in osteoarthritis of the knee and soft tissue injuries

Banning

2008

Expert Opinion on Pharmacotherapy

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Topical diclofenac: Clinical effectiveness and current uses in osteoarthritis of the knee and soft tissue injuries.Maggi Banning, EdD, M.Sc, PGDE, B.Sc. Senior lecturer, Brunel University.Background: Diclofenac is a commonly used non steroidal anti-inflammatory drug (NSAID) for symptom control in osteoarthritis (OA) of the knee and soft tissue injuries. Although treatment with oral diclofenac is associated with serious adverse effects involving both the gastrointestinal and renal systems, these adverse effects are thought to be limited with topical diclofenac formulations without loss of efficacy.Objective: the aim of this review is to explore the available evidence in relation to the pharmacokinetics, efficacy and reported adverse effects of the topical diclofenac formulations available. Results/conclusions: In the majority of studies examined, topical diclofenac formulations with sodium lotion, lecithin or epolamine gel, patch or plaster were either superior or equivalent to oral diclofenac formulations or placebo.Topical diclofenac significantly reduced pain and morning stiffness and improved physical function and patient global assessment without major adverse effects reported in patients with OA of the knee and provided significant pain relief in patients with sports and soft tissue injuries involving the ankle, knee or shoulder. In the majority of studies reported the predominant adverse effect involved pruritus or rash at the site of application or nausea. The principle outcome of these studies is that topical diclofenac is a safe and practical alternative as a method of treatment in OA of the knee or as an alternative treatment for sports and soft tissue injury.

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Are cytokines involved in osteoarthritic pathophysiology?

Cited by 129 publications

References 94 publications

Requirements of Focal Adhesions and Calcium Fluxes for Interleukin-1-induced ERK Kinase Activation and c-fos Expression in Fibroblasts

Requirements of Focal Adhesions and Calcium Fluxes for Interleukin-1-induced ERK Kinase Activation and c-fos Expression in Fibroblasts

Effect of oral diacerein (DAR) in an experimental hip chondrolysis model

Topical diclofenac: clinical effectiveness and current uses in osteoarthritis of the knee and soft tissue injuries

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