Are diet–prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-1 and IGFBP-3 in healthy middle-aged men

Gunnell, David; Oliver, Steven; Peters, Tim J.; Donovan, Jenny; Persad, Raj; Maynard, Maria; Gillatt, David; Pearce, A.; Hamdy, Freddie C.; Neal, David E.; Holly, Jeff M.P.

doi:10.1038/sj.bjc.6600946

Cited by 116 publications

(114 citation statements)

References 26 publications

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“…Both energy and protein are needed to restore IGF-I after fasting [11]. Our results, in a study population with adequate intake of energy and protein, are consistent with most previous cross-sectional studies, in which no association between energy and protein intake and circulating IGF-I and IGFBP-3 was observed [12][13][14][15][16][17][18][19][20]. The two largest cross-sectional studies did show a positive association between IGF-I and protein intake within the normal range [22,23], as is also found by two smaller studies [21,24].…”

Section: Discussionsupporting

confidence: 89%

“…In our study, no association between either tomatoes or lycopene and IGF-I or IGFBP-3 was observed. Four cross-sectional studies have investigated the relationship between tomato consumption [14,15,18] or lycopene intake [22] and IGF-I and IGFBP-3. In three of these studies, higher intake of cooked or processed tomatoes or lycopene was associated with either lower IGF-I levels [14], higher IGFBP-3 levels [22], or a lower IGF-I/IGFBP-3 molar ratio [18].…”

Section: Discussionmentioning

confidence: 99%

“…Four cross-sectional studies have investigated the relationship between tomato consumption [14,15,18] or lycopene intake [22] and IGF-I and IGFBP-3. In three of these studies, higher intake of cooked or processed tomatoes or lycopene was associated with either lower IGF-I levels [14], higher IGFBP-3 levels [22], or a lower IGF-I/IGFBP-3 molar ratio [18]. Two in vitro studies have shown that lycopene can inhibit IGF-I-stimulated growth of endometrium and mammary cancer cell lines [34,35].…”

Section: Discussionmentioning

confidence: 99%

“…Severe energy and protein restriction was found to lower serum IGF-I levels in both animals and humans [11]. Results of cross-sectional studies investigating the relation between the normal range of energy and protein intake and serum IGF-I levels are conflicting [12][13][14][15][16][17][18][19][20], with only few studies showing a significant positive association [21][22][23][24]. Alcohol consumption can possibly increase IGF-I production by the liver [25], but has been inconsistently related to IGF-I and IGFBP-3 levels in cross-sectional studies [14,15,17,22,26].…”

Section: Introductionmentioning

confidence: 99%

“…Lycopene is an anti-oxidant mainly found in cooked or processed tomatoes, and has been suggested to interfere with IGF signaling in experimental studies [34][35][36]. Also in cross-sectional studies lycopene [22] or cooked or processed tomatoes [14,18] were associated with IGF-I or IGFBP-3.…”

Section: Introductionmentioning

confidence: 99%

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Dietary Determinants of Circulating Insulin-like Growth Factor (IGF)-I and IGF Binding Proteins 1, -2 and -3 in Women in the Netherlands

Vrieling

Voskuil

Mesquita

et al. 2004

Cancer Causes Control

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Objective: Epidemiological studies suggest that individuals with elevated plasma concentrations of insulin-like growth factor (IGF-I) are at increased risk of developing cancer. We assessed whether dietary intake of total energy, protein, alcohol, phytoestrogens and related foods, and tomatoes and lycopene was associated with plasma levels of IGF-I and IGF binding proteins (IGFBPs) in Dutch women. Methods: A cross-sectional study was conducted in 224 premenopausal and 162 postmenopausal women, aged 49-69, participating in the Prospect-EPIC study in the Netherlands. Diet was assessed using a food frequency questionnaire. Results: In postmenopausal women, higher alcohol intake was associated with lower plasma IGFBP-1 concentrations (alcohol 1.4 to 20 g/day: 20% decrease in IGFBP-1; p ¼ 0.04), and higher intake of plant lignans was associated with higher IGFBP-1 concentrations (plant lignans 0 to 1 mg/day: 59% increase in IGFBP-1; p ¼ 0.02). Higher soy intake was associated with higher plasma IGFBP-2 concentrations in premenopausal women (soy 0 to 2.5 g/day: 3% increase in IGFBP-2; p ¼ 0.04). No independent associations of dietary factors with IGF-I or IGFBP-3 concentrations were observed. However, in premenopausal women alcohol intake was inversely associated with IGF-I and positively associated with IGFBP-3 after mutual adjustment. Conclusions: In this study population, with limited variation in dietary intake, total energy, protein, phytoestrogens and lycopene were not associated with IGF-I and IGFBP-3. Alcohol was inversely, and some measures of phytoestrogen intake were positively associated with plasma IGFBP-1 or -2 concentrations. The roles of IGFBP-1 and -2 in relation to IGF-I bioactivity and cancer deserve further investigation.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Dietary Determinants of Circulating Insulin-like Growth Factor (IGF)-I and IGF Binding Proteins 1, -2 and -3 in Women in the Netherlands

Vrieling

Voskuil

Mesquita

et al. 2004

Cancer Causes Control

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Affinity Peptidomics Approach to Protein Detection, Quantification, and Protein Affinity Assays: Application to Forensics and Biometrics

Bailes

Soloviev

2007

Peptidomics

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Dairy and milk consumption and child growth: Is BMI involved? An analysis of NHANES 1999–2004

Wiley

2010

American J Hum Biol

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Humans are unique among mammals in that many consume cow's milk or other dairy products well beyond the traditional age of weaning. Milk provides various nutrients and bioactive molecules to support growth and development, and the question arises as to whether this dietary behavior influences growth parameters. There is evidence that milk makes positive contributions to growth in height, but its associations with other aspects of body size, such as body mass index (BMI), are not well-established. National Health and Nutrition Examination Survey (NHANES) data from 1999 to 2004 and multivariate regression analysis were used to test the hypothesis that milk (g) or total dairy product consumption (kJ) is associated with higher BMI percentile among US White, Black, and Mexican-American children of age 2-4 years (n = 1,493) and 5-10 years (n = 2,526). Younger children in the highest quartile of dairy intake had higher BMIs (beta = 7.5-8.0; P < 0.01) than those in the lowest two quartiles. Controlling for energy intake eliminated differences between QIV and QI. Among children of 5-10 years of age dairy intake had no relationship to BMI. Young children in the highest quartile of milk intake had higher BMIs than all lower quartiles (beta = 7.1-12.8; beta = 6.3-11.8 in energy-controlled models; P < 0.05). Among children of 5-10 years of age, those in QIV for milk intake had higher BMIs than those in QII (beta = 8.3; beta = 7.1 in energy-controlled model; P < 0.01). Controlling for total protein or calcium did not change the results. Milk had more consistent positive associations with BMI than did dairy products, and these were strongest among children of 2-4 years of age.

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Are diet–prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-1 and IGFBP-3 in healthy middle-aged men

Cited by 116 publications

References 26 publications

Dietary Determinants of Circulating Insulin-like Growth Factor (IGF)-I and IGF Binding Proteins 1, -2 and -3 in Women in the Netherlands

Dietary Determinants of Circulating Insulin-like Growth Factor (IGF)-I and IGF Binding Proteins 1, -2 and -3 in Women in the Netherlands

Affinity Peptidomics Approach to Protein Detection, Quantification, and Protein Affinity Assays: Application to Forensics and Biometrics

Dairy and milk consumption and child growth: Is BMI involved? An analysis of NHANES 1999–2004

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