Are different subtypes of autism spectrum disorders associated with different factors?

Dealberto, Marie-José

doi:10.1111/acps.12063

Cited by 4 publications

(2 citation statements)

References 10 publications

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“…While the strength of the association between parental immigrant status and offspring neurodevelopmental problems, including ASD, varies across studies, systematic reviews have found support for this association [Abdullahi et al, 2018;Crafa & Warfa, 2015;Dealberto, 2011;Kawa et al, 2017;Ng, de Montigny, Ofner, & Docé, 2017]. There is suggestion that elevations in ASD risk in children of immigrants are mainly attributable to particular neurodevelopmental phenotypes, characterized by intellectual disability and language delay [Abdullahi et al, 2019;Dealberto, 2013]. Children of first generation immigrants may be at higher risk than those of second generation immigrants or nonimmigrant ethnic minority parents, but evidence in this area is mixed and results vary depending on the mother's region of origin.…”

Section: Introductionmentioning

confidence: 99%

Maternal immigrant status and signs of neurodevelopmental problems in early childhood: The French representative ELFE birth cohort

et al. 2019

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A growing body of evidence suggests that children of immigrants may have increased risks of neurodevelopmental disorders. However, evidence based on parent report and on very young children is lacking. We therefore investigated the association between maternal immigrant status and early signs of neurodevelopmental problems in a population‐based sample of 2‐year‐old children using standardized parent‐report instruments. We used data from the French representative Étude Longitudinale Française depuis l'Enfance birth cohort, initiated in 2011. The study sample included 9,900 children of nonimmigrant French, 1,403 children of second, and 1,171 children of first generation immigrant women followed‐up to age 2 years. Neurodevelopment was assessed using the Modified Checklist for Autism in Toddlers (M‐CHAT) and an adaptation of the MacArthur‐Bates Communicative Development Inventories (MB‐CDI). In fully adjusted linear regression models, maternal immigrant status was associated with M‐CHAT scores, with stronger associations in children of first (β‐coefficient: 0.19; 95% CI 0.08–0.29) than second generation immigrants (0.09; 0.01–0.17). This association was especially strong among children of first generation immigrant mothers native of North Africa (vs. nonimmigrant French: 0.33; 0.16–0.49) and French‐speaking Sub‐Saharan Africa (0.26; 0.07–0.45). MB‐CDI scores were lowest among children of first generation immigrant mothers, particularly from mostly non‐francophone regions. Children of first generation immigrant mothers were most likely to have simultaneously low MB‐CDI and high M‐CHAT scores. Our findings suggest that maternal immigrant status is associated with early signs of neurodevelopmental difficulties, with strong variations according to maternal region of origin. Further research is necessary to test whether these associations persist and to determine the underlying mechanisms. Autism Res 2019, 12: 1845–1859. © 2019 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary We asked immigrant and nonimmigrant mothers in France about early signs of neurodevelopmental problems in their 2‐year‐old children. Overall, we found that children of immigrants may be at higher risk of showing these early warning signs, as compared to children of nonimmigrants. This is in line with previous studies, which were based on doctors' diagnoses at later ages. However, our results differed depending on the mothers' regions of origin. We found the highest risks in children of first generation immigrants from North and French‐speaking Sub‐Saharan Africa, who also seemed especially at risk of neurodevelopmental problems combined with low language development.

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Section: Introductionmentioning

confidence: 99%

Maternal immigrant status and signs of neurodevelopmental problems in early childhood: The French representative ELFE birth cohort

et al. 2019

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“…Autism is a heterogeneous neurodevelopmental disorder that is characterized by a wide spectrum of social and communication difficulties, repetitive and restricted behaviors, and a variety of clinical symptoms (Antshel et al 2013;Georgiades et al 2012;Kohane et al 2012;Lai et al 2013;Lenroot and Yeung 2013;Nazeer and Ghaziuddin 2012). While the DSM5 defined all individuals with autism as belonging to a single diagnostic category, it has been proposed that classification of autism into more homogenous subtypes will facilitate research, diagnosis, and treatment of the disorder (Dealberto 2013;Gabis and Pomeroy 2014;Kim et al 2015;Lane et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Brief Report: The Negev Hospital-University-Based (HUB) Autism Database

Meiri

Dinstein

Michaelowski

et al. 2017

J Autism Dev Disord

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Elucidating the heterogeneous etiologies of autism will require investment in comprehensive longitudinal data acquisition from large community based cohorts. With this in mind, we have established a hospital-university-based (HUB) database of autism which incorporates prospective and retrospective data from a large and ethnically diverse population. The collected data includes social-demographic characteristics, standardized behavioral testing, detailed clinical history from electronic patient records, genetic samples, and various neurological measures. We describe the initial cohort characteristics following the first 18 months of data collection (188 children with autism). We believe that the Negev HUB autism database offers a unique and valuable resource for studying the heterogeneity of autism etiologies across different ethnic populations.

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The Negev hospital-university-based (HUB) autism database

Meiri

Dinstein

Michaelowski

et al. 2017

Preprint

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Elucidating the heterogeneous etiologies of autism will require investment in comprehensive longitudinal data acquisition from large community based cohorts. With this in mind, we have established a hospital-university-based (HUB) database of autism which incorporates prospective and retrospective data from a large and ethnically diverse population. Here we present initial findings from 188 children who were diagnosed with autism during the first eighteen months of the study. The unique characteristics of this cohort included: significant differences between Bedouin and Jewish children in different risk factors and clinical characteristics; complete birth records for >90% of the children; and a high frequency of consanguineous marriages. Thus, the Negev HUB autism database comprises a remarkably unique resource to study different aspects of autism.

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Are different subtypes of autism spectrum disorders associated with different factors?

Cited by 4 publications

References 10 publications

Maternal immigrant status and signs of neurodevelopmental problems in early childhood: The French representative ELFE birth cohort

Maternal immigrant status and signs of neurodevelopmental problems in early childhood: The French representative ELFE birth cohort

Brief Report: The Negev Hospital-University-Based (HUB) Autism Database

The Negev hospital-university-based (HUB) autism database

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