Are E‐cigarettes a safe and good alternative to cigarette smoking?

Rom, Oren; Pecorelli, Alessandra; Valacchi, Giuseppe; Reznick, Abraham Z.

doi:10.1111/nyas.12609

Cited by 185 publications

(149 citation statements)

References 40 publications

Supporting

Mentioning

142

Contrasting

Unclassified

Order By: Relevance

“…E-Cig users are a fast-growing subset of nicotine users who are described as "vapers" rather than smokers, since E-Cigs heat and generate aerosols but do not burn e-liquids. There is considerable controversy regarding the disease risk and toxicity of E-Cigs (112,116,127). However, because E-Cigs do not currently fall under the auspices of the Food and Drug Administration (FDA), they have not undergone the typical toxicological evaluation, followed by human clinical trials that are required of other inhaled products (e.g., inhaled therapeutic agents), and, as such, no safety data exist from either humans or animals.…”

mentioning

confidence: 99%

Will chronic e-cigarette use cause lung disease?

Rowell

Tarran

2015

American Journal of Physiology-Lung Cellular and Molecular Phys

105

View full text Add to dashboard Cite

Chronic tobacco smoking is a major cause of preventable morbidity and mortality worldwide. In the lung, tobacco smoking increases the risk of lung cancer, and also causes chronic obstructive pulmonary disease (COPD), which encompasses both emphysema and chronic bronchitis. E-cigarettes (E-Cigs), or electronic nicotine delivery systems, were developed over a decade ago and are designed to deliver nicotine without combusting tobacco. Although tobacco smoking has declined since the 1950s, E-Cig usage has increased, attracting both former tobacco smokers and never smokers. E-Cig liquids (e-liquids) contain nicotine in a glycerol/propylene glycol vehicle with flavorings, which are vaporized and inhaled. To date, neither E-Cig devices, nor e-liquids, are regulated by the Food and Drug Administration (FDA). The FDA has proposed a deeming rule, which aims to initiate legislation to regulate E-Cigs, but the timeline to take effect is uncertain. Proponents of E-Cigs say that they are safe and should not be regulated. Opposition is varied, with some opponents proposing that E-Cig usage will introduce a new generation to nicotine addiction, reversing the decline seen with tobacco smoking, or that E-Cigs generally may not be safe and will trigger diseases like tobacco. In this review, we shall discuss what is known about the effects of E-Cigs on the mammalian lung and isolated lung cells in vitro. We hope that collating this data will help illustrate gaps in the knowledge of this burgeoning field, directing researchers toward answering whether or not E-Cigs are capable of causing disease.

show abstract

mentioning

confidence: 99%

Will chronic e-cigarette use cause lung disease?

Rowell

Tarran

2015

American Journal of Physiology-Lung Cellular and Molecular Phys

105

View full text Add to dashboard Cite

show abstract

“…E-cigarette use significantly reduces the exposure to tobacco-related carcinogens and toxicants when used instead of regular cigarettes (McNeill et al, 2015). However, they are not harmless (Goniewicz et al, 2014; Rom et al, 2014). In many countries, advertising of e-cigarettes is not subject to the same restrictions as those imposed on the advertising of regular cigarettes.…”

Section: Introductionmentioning

confidence: 99%

E-cigarette advertisements, and associations with the use of e-cigarettes and disapproval or quitting of smoking: Findings from the International Tobacco Control (ITC) Netherlands Survey

Nagelhout

Heijndijk²,

Cummings

et al. 2016

International Journal of Drug Policy

View full text Add to dashboard Cite

Background Much attention has been directed towards the possible effects of e-cigarette advertisements on adolescent never smokers. However, e-cigarette advertising may also influence perceptions and behaviors of adult smokers. The aim of our study was to examine whether noticing e-cigarette advertisements is associated with current use of e-cigarettes, disapproval of smoking, quit smoking attempts, and quit smoking success. Methods We used longitudinal data from two survey waves of the ITC Netherlands Survey among smokers aged 16 years and older (n=1198). Respondents were asked whether they noticed e-cigarettes being advertised on television, on the radio, and in newspapers or magazines in the previous 6 months. Results There was a significant increase in noticing e-cigarette advertisements between 2013 (13.3%) and 2014 (36.0%), across all media. The largest increase was for television advertisements. There was also a substantial increase in current use of e-cigarettes (from 3.1% to 13.3%), but this was not related to noticing advertisements in traditional media (OR=0.99, p=0.937). Noticing advertisements was bivariately associated with more disapproval of smoking (Beta=0.05, p=0.019) and with a higher likelihood of attempting to quit smoking (OR=1.37, p=0.038), but these associations did not reach significance in multivariate analyses. There was no significant association between noticing advertisements and quit smoking success in either the bivariate or multivariate regression analysis (OR=0.92, p=0.807). Conclusion Noticing e-cigarette advertisements increased sharply in the Netherlands between 2013 and 2014 along with increased e-cigarette use, but the two appear unrelated. The advertisements did not seem to have adverse effects on disapproval of smoking and smoking cessation.

show abstract

“…Even more impressive, the effectiveness of e-cigarettes for smoking cessation or reduction was examined in a survey of 222 smokers who had tried ecigarettes: 31% reported smoking abstinence after 6 months and 67% reported a reduction in the number of cigarettes they smoked (Rom et al, 2015). A study following 40 switchers, showed sustained smoking abstinence after six months in 23%, with 6/9 still using the e-cigarette by the end of the study.…”

Section: The Promise Of E-cigarettesmentioning

confidence: 99%

“…More pragmatic health professionals will see the opportunity to help many smokers to quit. (Rom et al, 2015). But should this be left to prescription controlled by physicians?…”

Section: E-cigarettes -The Ugly Duckling Of Public Health?mentioning

confidence: 99%

E-cigarettes and the need and opportunities for alternatives to animal testing

Hartung

2016

ALTEX

View full text Add to dashboard Cite

Are E‐cigarettes a safe and good alternative to cigarette smoking?

Cited by 185 publications

References 40 publications

Will chronic e-cigarette use cause lung disease?

Will chronic e-cigarette use cause lung disease?

E-cigarette advertisements, and associations with the use of e-cigarettes and disapproval or quitting of smoking: Findings from the International Tobacco Control (ITC) Netherlands Survey

E-cigarettes and the need and opportunities for alternatives to animal testing

Contact Info

Product

Resources

About