Are early‐life antecedents of suicide mortality associated with psychiatric disorders and suicidal ideation in midlife?

Geoffroy, Marie‐Claude; Gunnell, David; Clark, Charlotte; Power, Chris

doi:10.1111/acps.12844

Cited by 14 publications

(16 citation statements)

References 24 publications

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“…The pattern of association was similar for psychiatric disorders, although the statistical evidence of a dose–response effect was weaker. Few previous studies have investigated the association of birth order and offspring psychiatric disorder, the current study adds support to previous studies that have and that reported later-born children to be at greatest risk of mental health problems, and increased risk of suicide [3, 15, 31]. Any differences in strength of association for outcomes of suicide attempts and psychiatric disorder could reflect a different aetiology of suicidal behaviour [20] and mental health, and the relative contribution of birth order to these outcomes.…”

Section: Discussionsupporting

confidence: 81%

Association of birth order with adolescent mental health and suicide attempts: a population-based longitudinal study

Easey¹,

Mars

Pearson

et al. 2019

Eur Child Adolesc Psychiatry

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Previous cohort studies have observed higher birth order to be associated with increased risk of suicidal behaviour. However, the mechanisms underlying this association are unclear. Using data from the Avon Longitudinal Study of Parents and Children (ALSPAC), we used multivariable logistic regression models and mediation analysis to investigate the associations of birth order with adolescent suicide attempts and psychiatric disorder. We investigated whether the number of maternal depressive episodes and father absence mediated the associations found. In fully adjusted models ( n = 2571), higher birth order was associated with an increased risk of both suicide attempts (OR = 1.42, CI = 1.10–1.84) and psychiatric disorder (OR = 1.29, CI = 0.99–1.69). Maternal depression and father absence only partially mediated (8%; 12%) these associations. Whilst maternal depression and paternal absence partially mediated the associations between birth order, and suicidal behaviour and psychiatric disorder, other pathways may account for much of these associations. Future studies should investigate alternative mediating pathways. Electronic supplementary material The online version of this article (10.1007/s00787-018-1266-1) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 81%

Association of birth order with adolescent mental health and suicide attempts: a population-based longitudinal study

Easey¹,

Mars

Pearson

et al. 2019

Eur Child Adolesc Psychiatry

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“…Age of parents. There were nine studies exploring the association between having teen parents (<20 years old) and depression in offspring in the meta-analysis (Buizer-Voskamp et al, 2011;Geoffroy et al, 2018;Herva et al, 2008;Levine, 2014;Pereira et al, 2012;Slykerman et al, 2015 Figure 2 Pooled ORs for the association between prenatal, perinatal, and postnatal factors and depression risk. Gale 1 is the study among females, Gale 2 is the study among males; Nomura 1 is the New York State Psychiatric Institute/Columbia University study, Nomura 2 is the National Collaborative Perinatal Project (NCPP) study; Pereira 1 study compares depression in children 7-9 years with maternal factors, Pereira 2 study compares depression in children 10-11 years with maternal factors, Pereira 3 study compares depression in children 7-9 years with paternal factors, Pereira 4 study compares depression in children 10-11 years with paternal factors; Joinson 1 study compares depression in children less than 12 years old, Joinson 2 study compares depression in children at 12-16 years old, Joinson 3 study compares depression in children at 12-17 years old; Phillips 1 is the study on prenatal stress, Phillips 2 is the study on prenatal stress; Taylor 1 is the ALSPAC study, Taylor 2 is the HUNT study, and Taylor evidence of heterogeneity between studies (I = 32%, p = .16).…”

Section: Biological Factorsmentioning

confidence: 99%

Research Review: Developmental origins of depression – a systematic review and meta‐analysis

D’Arcy

Meng

2020

Child Psychology Psychiatry

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Background: Many observational studies have found a direct association between adverse in utero, perinatal and postnatal exposures and offspring's depression. These findings are consistent with the 'developmental origins of disease hypothesis'. But no review has comprehensively summarized the roles of these exposures. This review aims to systematically scrutinize the strength of associations between individual prenatal, perinatal, and postnatal exposures and subsequent depression in offspring. Methods: We conducted a systematic review and meta-analysis to synthesize the literature from the EMBASE, HealthStar, PsychoInfo, and Medline databases since their inception to September 1, 2019. English language articles on population-based prospective cohort studies examining the associations between in utero, perinatal, and postnatal exposures and offspring's depression were searched. Random-effects models were used to calculate pooled estimates, and heterogeneity and sensitivity tests were conducted to explore potential confounders in the relationships of depression and early-life factors. Qualitative analysis was also conducted. Results: Sixty-four prospective cohort studies with 28 exposures studied in the relationships to offspring's depression met inclusion criteria. The meta-analysis found 12 prenatal, perinatal, and postnatal characteristics were associated with an increased risk of depression in offspring: low birth weight, premature birth, small gestational age, maternal education, socioeconomic status, having younger parents (<20 years), having older parents (≥35 years), maternal smoking, paternal smoking, maternal stress, maternal anxiety, and prenatal depression. Heterogeneity and sensitivity tests supported the findings. By and large, study characteristics had no effects on conclusions. Qualitative analyses generally supported the findings of meta-analysis and reported on additional risk factors. Conclusions: This review provides a robust and comprehensive overview of the lasting psychopathological effects of in utero, perinatal, and postnatal exposures. The findings highlight the need for clinical and public health interventions focusing on the identified risk factors. Large prospective cohort studies are warranted to investigate the combined effects of multiple co-existing early-life exposures.

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“…On the basis of this study and the comparison of three trajectories of peer-victimization-low, moderate, and severe from the ages of 6-13 years old-MGSS researchers report that adolescents who were more severely victimized throughout their school journey are "at greater chance of suicidality in adolescence than less severely victimized children, even accounting for a plethora of confounders assessed throughout childhood" (Geoffroy et al, 2018a, p. 41). Another cohort study of interest to the team is the 1958 National Child Development Study (NCDS) based in Britain, in which these researchers further identified perinatal risk factors (e.g., young maternal age), and developmental risk factors (i.e., externalizing behaviors) and correlated these with the number of childhood adversities that were associated with suicidality later in life (Geoffroy et al, 2018b). The findings produced through these cohort study analyses, thus far, are consistent with those from previous ACEs studies (Anda et al, 2006), in which researchers identified "a dose-response association between the number of emotional adversities and suicide, with the highest suicide risks [found] among those experiencing three or more adverse experiences" (Geoffroy et al, 2014, p. 10).…”

Section: Modeling Early Adversity As a Major Risk Factormentioning

confidence: 99%

Troubling Neurobiological Vulnerability: Psychiatric Risk and the Adverse Milieu in Environmental Epigenetics Research

2021

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In post-genomic science, the development of etiological models of neurobiological vulnerability to psychiatric risk has expanded exponentially in recent decades, particularly since the neuromolecular and biosocial turns in basic research. Among this research is that of McGill Group for Suicide Studies (MGSS) whose work centers on the identification of major risk factors and epigenetic traits that help to identify a specific profile of vulnerability to psychiatric conditions (e.g., depression) and predict high-risk behaviors (e.g., suicidality). Although the MGSS has attracted attention for its environmental epigenetic models of suicide risk over the years and the translation of findings from rodent studies into human populations, its overall agenda includes multiple research axes, ranging from retrospective studies to clinical and epidemiological research. Common to these research axes is a concern with the long-term effects of adverse experiences on maladaptive trajectories and negative mental health outcomes. As these findings converge with post-genomic understandings of health and also translate into new orientations in global public health, our article queries the ways in which neurobiological vulnerability is traced, measured, and profiled in environmental epigenetics and in the MGSS research. Inspired by the philosophy of Georges Canguilhem and by literature from the social studies of risk and critical public health, we explore how the epigenetic models of neurobiological vulnerability tie into a particular way of thinking about the normal, the pathological, and the milieu in terms of risk. Through this exploration, we examine how early life adversity (ELA) and neurobiological vulnerability are localized and materialized in those emerging models while also considering their broader conceptual and translational implications in the contexts of mental health and global public health interventions. In particular, we consider how narratives of maladaptive trajectories and vulnerable selves who are at risk of harm might stand in as a “new pathological” with healthy trajectories and resilient selves being potentially equated with a “new normal” way of living in the face of adversity. By troubling neurobiological vulnerability as a universal biosocial condition, we suggest that an ecosocial perspective may help us to think differently about the dynamics of mental health and distress in the adverse milieu.

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Are early‐life antecedents of suicide mortality associated with psychiatric disorders and suicidal ideation in midlife?

Abstract: Associations for younger maternal age, higher birth order and adversities with adult internalizing disorders suggest that psychiatric disorders may be on the pathway linking some early-life factors and suicide.

Cited by 14 publications

References 24 publications

Association of birth order with adolescent mental health and suicide attempts: a population-based longitudinal study

Association of birth order with adolescent mental health and suicide attempts: a population-based longitudinal study

Research Review: Developmental origins of depression – a systematic review and meta‐analysis

Troubling Neurobiological Vulnerability: Psychiatric Risk and the Adverse Milieu in Environmental Epigenetics Research

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