Are fish oil-based dietary supplements a significant source of exposure to chlorinated paraffins?

An Overview of the Untargeted Analysis Using LC–MS (QTOF): Experimental Process and Design Considerations

“…The concentrations were in the range of 1.01-37.22 µg/g lw (SCCPs) and 0.83-37.76 µg/g lw (MCCPs), respectively. These results were lower than concentrations obtained by GC-HRMS in our previously published study (16). The differences may have been caused by still remaining matrix effects, even after sulfuric acid treatment of the samples.…”

“…for this study. The detailed list is documented in our previous paper (16). Isotopically labeled internal standard of β-hexabromocyclododecane ( 13 C 12 -β-HBCD; 50 µg/mL toluene) was purchased from Wellington Laboratories.…”

“…In this study, a sample of fish oil-based dietary supplements with no measurable CPs contamination found in a previous study (16) were chosen for method development and validation. Four other samples (with higher levels of CPs contamination previously determined by GC-HRMS) were analyzed to compare the new methods.…”

“…A previously published SFC-based method (16) was used in this study with several modifications (gradient of mobile phases, composition of mobile phase B, and make-up solvent were changed). The supercritical fluid chromatograph Acquity UPC 2 coupled with a Synapt G2 Si high-resolution mass spectrometer (both Waters) with electrospray ionization operated in a negative mode was employed.…”

“…Our new online directory quickly connects you with chromatography professionals and buyers around the world. www.ChromatographyDirectory.com Explore Listings Submit Your Listing regarding injection solvent; that is, the use of acetonitrile in this study and isooctane used elsewhere (16), where the samples prepared for GC-HRMS analysis (in isooctane) were also measured by SFC-HRMS (as a complementary method for screening of LCCPs).…”