Are gastrointestinal and sleep problems associated with behavioral symptoms of autism spectrum disorder?

Yang, Xiaolei; Liang, Shuang; Zou, Mingyang; Sun, Chongde; Han, Panpan; Jiang, Xi-Tao; Xia, Wei; Wu, Lijie

doi:10.1016/j.psychres.2017.10.040

Cited by 57 publications

(50 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The total score range is between 15 and 60, with higher scores indicating more severe levels of autism. It has been validated in studies in Chinese children with ASD (2,12,36). The Cronbach's alpha coefficients for the CARS were 0.735 in a prior Chinese study (37) and 0.83 in our study.…”

Section: Childhood Autism Rating Scale (Cars)supporting

confidence: 49%

“…The prevalence of sleep disturbances in children with ASD is as high as 50-80% in Western countries, which is approximately two or three times higher than the prevalence in typically developing (TD) children (20-50%) (4,5,10). An estimated 70-90% of Chinese children with ASD experience sleep disturbances (11,12) compared to 15-80% of TD children (13,14). Sleep problems were also reported more frequently among preschool-aged children with ASD compared to their TD peers in Western countries.…”

Section: Introductionmentioning

confidence: 99%

“…Numerous studies have shown that a wide variety of persistent sleep difficulties experienced by ASD children exacerbate their core autistic symptoms (25) and are associated with many conditions that co-occur with ASD including increased anxiety, sensory over-responsivity (26), selfstimulatory behavior, and daytime challenging behavior (27), as well as medical comorbidities such as gastrointestinal problems (12) and epilepsy (28). Among children with ASD, poor sleepers exhibit more ritualistic, compulsive, irritable, and hyperactive behavior than good sleepers (29,30).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Sleep Problems Influence Emotional/Behavioral Symptoms and Repetitive Behavior in Preschool-Aged Children With Autism Spectrum Disorder in the Unique Social Context of China

et al. 2020

View full text Add to dashboard Cite

Sleep disturbances are common in people with autism spectrum disorder (ASD), but research on this topic is still limited in China. In the current study, we evaluated the prevalence of sleep problems in preschool-aged children with ASD and to examine the correlations between sleep disturbances and emotional/behavioral symptoms and repetitive behavior in the unique social context of China. This study recruited 475 preschool-aged children aged 3-6 years old, including 252 children with ASD (mean age 5.13 ± 1.15, 80.6% male) and 223 age-matched typically developing (TD) children (mean age 5.12 ± 0.97, 74.9% male). The parents of all children completed a sociodemographic questionnaire and the Childhood Sleep Habits Questionnaire. The parents of 114 ASD children completed the Strengths and Difficulties Questionnaire (SDQ) and the Repetitive Behavioral Questionnaire-2 (RBQ-2). The prevalence of sleep problems in preschool-aged children with ASD in this study was 81.7%, which was higher than that in TD children (61.0%). The scores for bedtime resistance, sleep anxiety, sleep duration, parasomnias, and sleep onset delay in the ASD group were significantly higher than those in the TD group (t=−7.664, P=0.000; t=−10.477, P=0.000; t=−4.133, P=0.000; Z= −3.916, P=0.000; Z=−7.093, P=0.000; respectively). Sleep onset delay explained 17.3% of the variance (adjusted R 2 = 0.173) in the total SDQ score of children with ASD, and bedtime resistance explained a large proportion of total RBQ-2 score variance (adjusted R 2 = 0.206). The high rate of sleep disturbances in preschool-aged children with ASD emphasizes the importance of screening for sleep problems in this population. Attention should also be directed toward formulating good sleep hygiene practices for preschool-aged children in the particular social context and cultural setting of China.

show abstract

Section: Childhood Autism Rating Scale (Cars)supporting

confidence: 49%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Sleep Problems Influence Emotional/Behavioral Symptoms and Repetitive Behavior in Preschool-Aged Children With Autism Spectrum Disorder in the Unique Social Context of China

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Nutrient de ciencies, such as vitamin D, vitamin E, and calcium, commonly occur in children with ASD [23,24]. A study on the level of vitamin D in adolescents revealed poor quality sleep was associated with vitamin D de ciency [25].…”

Section: Discussionmentioning

confidence: 99%

“…A study on the level of vitamin D in adolescents revealed poor quality sleep was associated with vitamin D de ciency [25]. Researchers also found that child's picky eating was related to sleep disturbances during development, though if extra nutrients were supplied to the mother during lactation, her child was less prone to sleep disturbances [24]. It is also worth noting that VA has been accepted as a necessary nutrient not only for regular patterns of brain activity but also for playing important roles in the development of ASD [26].…”

Section: Discussionmentioning

confidence: 99%

Vitamin A Deficiency and Sleep Disturbances Related to Autism Symptoms in Children with Autism Spectrum Disorder: A Cross-Sectional Study

Wen

Yang

Zhu

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Vitamin A deficiency (VAD) and sleep disturbances have been reported in children with autism spectrum disorder (ASD). The influence of vitamin A (VA) on sleep regulation and sleep disturbances in ASD has garnered increased attention. This study aims to characterize the effect of VA levels and sleep disturbances on children with ASD.Methods: This cross-sectional study compared children with ASD (n=856) to typically developing children (TDC; n=316). The Children’s Sleep Habits Questionnaire assessed sleep disturbances, Childhood Autism Rating Scale evaluated the severity of autism symptoms, and Autism Behavior Checklist and Social Responsiveness Scale assessed autism behaviors. VA levels in blood samples were measured using high-performance liquid chromatography. Multivariable linear regression and two-way ANOVAs were performed to investigate the effect of VAD and sleep disturbances in children with ASD.Results: Children with ASD had lower serum VA levels and a higher prevalence of sleep disturbances than TDC. VAD and sleep disturbances in children with ASD corresponded to the severity of autism symptoms. Importantly, VA levels were negatively correlated with sleep disturbances among children with ASD, and the interaction of VAD and sleep disturbances were related to the severity of autism symptoms.Conclusion: VAD and sleep disturbances exacerbated autism symptoms in children with ASD, providing a novel target for treatment.Trial registration: Chinese Clinical Trial Registry, registration number: ChiCTR-ROC-14005442

show abstract

Developmental–behavioral profiles in children with autism spectrum disorder and co‐occurring gastrointestinal symptoms

et al. 2020

View full text Add to dashboard Cite

Gastrointestinal (GI) symptoms are frequently reported in children with autism spectrum disorder (ASD). We evaluated the frequency and severity of GI symptoms in preschool-aged children with ASD compared to participants with typical development (TD). Our goal was to ascertain whether GI symptoms are associated with differences in sex or developmental and behavioral measures. Participants were between 2 and 3.5 years of age and included 255 children with ASD (184 males/71 females) and 129 age-matched TD controls (75 males/54 females). A parent interview was used to assess GI symptoms (abdominal pain, gaseousness/bloating, diarrhea, constipation, pain on stooling, vomiting, difficulty swallowing, blood in stool or in vomit). Children with GI symptoms in each diagnostic group were compared to children without GI symptoms on measures of developmental, behavioral, and adaptive functioning. GI symptoms were reported more frequently in children with ASD compared to the TD group (47.8% vs. 17.8%, respectively). Children with ASD were also more likely to experience multiple GI symptoms (30.6% vs. 5.4%). GI symptoms were equally common in males and females across both diagnostic groups. There were no statistically significant differences in developmental or adaptive measures based on presence of GI symptoms in either ASD or TD children. Co-occurring GI symptoms were, however, associated with increased self-injurious behaviors, restricted stereotyped behaviors, aggressive behaviors, sleep problems and attention problems in both ASD and TD children. In children with ASD, a higher number of GI symptoms was associated with an increase in self-injurious behaviors, somatic complaints, reduced sleep duration, and increased parasomnias.

show abstract

Are gastrointestinal and sleep problems associated with behavioral symptoms of autism spectrum disorder?

Cited by 57 publications

References 43 publications

Sleep Problems Influence Emotional/Behavioral Symptoms and Repetitive Behavior in Preschool-Aged Children With Autism Spectrum Disorder in the Unique Social Context of China

Sleep Problems Influence Emotional/Behavioral Symptoms and Repetitive Behavior in Preschool-Aged Children With Autism Spectrum Disorder in the Unique Social Context of China

Vitamin A Deficiency and Sleep Disturbances Related to Autism Symptoms in Children with Autism Spectrum Disorder: A Cross-Sectional Study

Developmental–behavioral profiles in children with autism spectrum disorder and co‐occurring gastrointestinal symptoms

Contact Info

Product

Resources

About