Are Genes Associated with Energy Metabolism Important in Asthma and BMI?

Szczepankiewicz, Aleksandra; Bręborowicz, Anna; Sobkowiak, Paulina; Popiel, Anna

doi:10.1080/02770900802460514

Cited by 25 publications

(22 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…BMI, body mass index; OR, odds ratio; CI, confidence interval. molecules leptin and tumor necrosis factor alpha (TNFα) as well as the ubiquitously expressed protein kinase C alpha, a factor associated with adipocyte differentiation and insulin signaling (7,22,23). Cell cycle control genes have so far not been investigated in this respect, but their importance in inflammatory processes confer them etiologic plausibility to potentially modify the obesity-asthma relationship.…”

Section: Asthma In Obese Peoplementioning

confidence: 99%

The Association of a Variant in the Cell Cycle Control GeneCCND1and Obesity on the Development of Asthma in the Swiss SAPALDIA Study

Thun¹,

Imboden²,

Berger³

et al. 2013

Journal of Asthma

View full text Add to dashboard Cite

OBJECTIVE: The molecular mechanisms underlying the association between obesity (BMI 30 kg/m(2)) and asthma are poorly understood. Since shifts in the fate of bronchial cells due to lowgrade systemic inflammation may provide a possible explanation, we investigated whether two of the best documented functional variants in cell cycle control genes modify the obesity-asthma association. METHODS: We genotyped 5930 SAPALDIA cohort participants for the single-nucleotide polymorphisms (SNPs) rs9344 in the cyclin D1 gene (CCND1) and rs1042522 in the gene encoding tumor protein 53 (TP53). We assessed the independent association of these SNPs and obesity with asthma prevalence and incidence. RESULTS: The CCND1 SNP modified the association between obesity and asthma prevalence (p(interaction )= 0.03). The odds ratios (ORs) and 95% confidence intervals (CIs) for reporting a physician diagnosis of asthma at baseline, comparing obese with non-obese participants, were 1.09 (0.51-2.33), 1.64 (0.94-2.88), and 3.51 (1.63-7.53) for GG, GA, and AA genotypes, respectively. We found comparable genotype differences for incident asthma within the 11 years of follow-up. As for the TP53 SNP, the interactions with obesity status with respect to asthma were not statistically significant. CONCLUSIONS: Our results suggest that obesity may contribute to asthma and associated tissue remodeling by modifying the processes related to the CCND1 gene activity. Objective. The molecular mechanisms underlying the association between obesity (BMI 30 kg/m 2 ) and asthma are poorly understood. Since shifts in the fate of bronchial cells due to low-grade systemic inflammation may provide a possible explanation, we investigated whether two of the best documented functional variants in cell cycle control genes modify the obesity-asthma association. Methods. We genotyped 5930 SAPALDIA cohort participants for the single-nucleotide polymorphisms (SNPs) rs9344 in the cyclin D1 gene (CCND1) and rs1042522 in the gene encoding tumor protein 53 (TP53). We assessed the independent association of these SNPs and obesity with asthma prevalence and incidence. Results. The CCND1 SNP modified the association between obesity and asthma prevalence (p interaction ¼ 0.03). The odds ratios (ORs) and 95% confidence intervals (CIs) for reporting a physician diagnosis of asthma at baseline, comparing obese with non-obese participants, were 1.09 (0.51-2.33), 1.64 (0.94-2.88), and 3.51 (1.63-7.53) for GG, GA, and AA genotypes, respectively. We found comparable genotype differences for incident asthma within the 11 years of follow-up. As for the TP53 SNP, the interactions with obesity status with respect to asthma were not statistically significant. Conclusions. Our results suggest that obesity may contribute to asthma and associated tissue remodeling by modifying the processes related to the CCND1 gene activity.of Asthma, 2013; 50(2): 147-154 Copyright © 2013 Informa Healthcare USA, Inc. ISSN: 0277-0903 print/1532-4303

show abstract

Section: Asthma In Obese Peoplementioning

confidence: 99%

The Association of a Variant in the Cell Cycle Control GeneCCND1and Obesity on the Development of Asthma in the Swiss SAPALDIA Study

Thun¹,

Imboden²,

Berger³

et al. 2013

Journal of Asthma

View full text Add to dashboard Cite

show abstract

“…12 PRKCA, LEP, and TNFa were studied in individual surveys and the results were promising. 8,9,11 Why the ADRB2 polymorphism seems to be worth studying in the context of asthma and obesity phenotype? The same defect, which leads to a poorer response to the bronchodilator treatment, could be responsible for inadequate lipolysis and energy storage thus affecting both conditions.…”

Section: Shared Genetic Factors For Asthma and Obesitymentioning

confidence: 99%

“…7 Between commonly shared genes, the most biologicaly plausible are those that are pleiotropic, including b2-adrenergic receptor (ADRB2), vitamin D receptor gene (VDR), leptin (LEP), protein kinase C alpha (PRKCA), and tumor necrosis factor a (TNFa). [8][9][10][11][12] Polymorphisms within ADRB2 were described in association with different disorders, including not only asthma and obesity but also hypertension, 13 autism, 14 cerebral palsy, 15 susceptibility to parasite infestation, 16 and rheumatoid arthritis. 17 The ADRB2 Gene…”

mentioning

confidence: 99%

What the Genetic Background of Individuals with Asthma and Obesity Can Reveal: Is β2-Adrenergic Receptor Gene Polymorphism Important?

Danielewicz

2014

Pediatric Allergy, Immunology, and Pulmonology

View full text Add to dashboard Cite

“…A pediatric case-control study has shown a significant association between polymorphisms in the leptin gene and asthma, although there were no associations with polymorphisms in the leptin receptor or ghrelin gene [35]. In familybased association studies involving parent-child trios in both a Costa Rican cohort, and the Childhood Asthma Management Program cohort, single-nucleotide polymorphisms (SNPs) of the PRKCA gene (protein kinase C alpha) were associated with both BMI and asthma [36 ].…”

Section: Shared Genetic Determinants In Obesity and Asthmamentioning

confidence: 99%

Recent insight into obesity and asthma

Beuther

2010

Current Opinion in Pulmonary Medicine

View full text Add to dashboard Cite

There are still far more questions than answers as to how obesity might cause or worsen asthma. It is clear that weight gain and obesity are particularly troublesome in asthmatics, and clinicians should target these individuals for aggressive intervention. Randomized controlled trials are needed to determine the best treatment approaches for obese asthma, and prospective studies in which both obesity and asthma are well characterized are needed to better understand the underlying mechanisms.

show abstract

Are Genes Associated with Energy Metabolism Important in Asthma and BMI?

Cited by 25 publications

References 34 publications

The Association of a Variant in the Cell Cycle Control GeneCCND1and Obesity on the Development of Asthma in the Swiss SAPALDIA Study

The Association of a Variant in the Cell Cycle Control GeneCCND1and Obesity on the Development of Asthma in the Swiss SAPALDIA Study

What the Genetic Background of Individuals with Asthma and Obesity Can Reveal: Is β2-Adrenergic Receptor Gene Polymorphism Important?

Recent insight into obesity and asthma

Contact Info

Product

Resources

About