Are Genetic Influences on Peptic Ulcer Dependent or Independent of Genetic Influences for Helicobacter pylori Infection?

Malaty, Hoda M.; Graham, David Y.; Isaksson, Inger; Engstrand, Lars; Pedersen, Nancy L.

doi:10.1001/archinte.160.1.105

Cited by 62 publications

(33 citation statements)

References 31 publications

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“…[48] Malaty et al . [55] examined the longitudinal changes in H. pylori infection monitored from 1986-1994 within 46 families with children living in Japan. At study entry, prevalence of H. pylori in children with positive mothers was 23% versus 5% in children with negative mothers.…”

Section: Modes Of Transmissionmentioning

confidence: 99%

Helicobacter pylori infection in developing countries: The burden for how long?

Salih

2009

Saudi J Gastroenterol

202

135

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Approximately 50% (over 3 billion) of the world populations are known to be infected with Helicobacter pylori, mainly in the developing countries. Among those, hundreds of millions of people develop peptic ulceration during their lifetime and still tens of millions might progress to gastric cancer. Possible modes of H. pylori transmission generally described are through direct contact between family members and also through contaminated water and food. Because the high prevalence of infection occurs mainly in developing countries and because the test-and-treat strategy puts a huge economic burden on many of these countries, it is time to take an immediate action toward this bacterial infection and adopt a strategy to prevent it. To address this issue, an updated prevalence of infection, modes of transmission, economics of infection and preventative measures to block the infection process have been discussed.

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Section: Modes Of Transmissionmentioning

confidence: 99%

Helicobacter pylori infection in developing countries: The burden for how long?

Salih

2009

Saudi J Gastroenterol

202

135

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“…A study of monozygotic and dizygotic twins reared together or reared apart, however, found that genetic influences for peptic ulcer were independent of genetic influences important for acquiring H pylori infection. Host genetics are probably less important than environmental factors or strain virulence in determining outcome [39].…”

Section: Host and Environmental Factors In H Pylori-related Ulcer Dismentioning

confidence: 99%

Pathogenesis and therapy of gastric and duodenal ulcer disease

Shiotani

Graham

2002

Medical Clinics of North America

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“…In virtually all of these children, inflammation of the gastric mucosa is present and caused by H. pylori infection [2][3][4][5]. Further evidence for the familial nature of primary gastritis and peptic ulceration in children is the clustering of H. pylori infection among family members [37][38][39][40]. More recently, work by El-Omar et al [41] has provided molecular evidence for the familial nature of gastric cancer associated with H. pylori infection.…”

Section: Overviewmentioning

confidence: 99%

New approaches to helicobacter pylori infection in children

Gold

2001

Curr Gastroenterol Rep

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Helicobacter pylori infection is usually acquired during childhood, and evidence-based guidelines regarding diagnosis and treatment of infected children have been recently published. Diseases associated with H. pylori infection are gastritis, duodenal ulcers, mucosal-associated lymphoid-type (MALT) lymphoma, and gastric adenocarcinoma. The association of specific symptoms with H. pylori infection in children and adults (ie, recurrent abdominal pain and nonulcer dyspepsia) remains controversial. Additionally, the role of H. pylori in gastroesophageal reflux disease or in extra-gastrointestinal diseases (ie, coronary artery disease) lacks sufficient evidence to demonstrate causality. The diagnosis of H. pylori-associated diseases in children can reliably be made through gastroduodenal endoscopy with biopsies. Clinical trials are underway for the validation of noninvasive diagnostic tests for the H. pylori-infected child, and current guidelines recommend eradication therapy for infected children with duodenal and gastric ulcer, gastric lymphoma, and atrophic gastritis with intestinal metaplasia. The natural history of childhood H. pylori infection is poorly described. Moreover, rational approaches to the prevention and control of childhood H. pylori infection are critically needed, requiring characterization of the determinants for acquisition and persistence and the disease outcomes following eradication.

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Are Genetic Influences on Peptic Ulcer Dependent or Independent of Genetic Influences for Helicobacter pylori Infection?

Abstract: Background: Genetic factors play a role or roles in the etiology of peptic ulcer disease and the acquisition of Helicobacter pylori infection.

Cited by 62 publications

References 31 publications

Helicobacter pylori infection in developing countries: The burden for how long?

Helicobacter pylori infection in developing countries: The burden for how long?

Pathogenesis and therapy of gastric and duodenal ulcer disease

New approaches to helicobacter pylori infection in children

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