Are Gujarati Asian Indians ‘older’ for their ‘vascular age’ as compared to their ‘Chronological age’?

Sharma, Kamal; Sahoo, Sibasish; Shah, Komal; Patel, A.; Jadhav, Nikhil; Parmar, Meena; Patel, Krutika H

doi:10.1093/qjmed/hcu158

Cited by 18 publications

(15 citation statements)

References 24 publications

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“…It is the most common condition seen in primary care which leads to myocardial infarction, stroke, renal failure, and death if not detected early and treated appropriately. The western Indian population is more susceptible to CVDs, being affected at a younger age (≤40 years of age), with risk factors possibly also starting to show up at an early age period [1]. Prevalence of HTN increases with increasing age which could be used as a measure of its future CVD burden.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Predictors of Undiagnosed Hypertension in an Apparently Healthy Western Indian Population

Shukla

Madan

Thakkar

et al. 2015

Advances in Epidemiology

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This epidemiological study was designed to evaluate the prevalence of undetected hypertension in an apparently healthy western Indian population having no history of major illness. 3629 individuals of ≥18 years of age were included in the study. Hypertension (HTN) was defined as systolic blood pressure (SBP) ≥ 140 mmHg or diastolic blood pressure (DBP) ≥ 90 mmHg and prehypertension (PHTN) as SBP ≥ 120-139 mmHg or DBP ≥ 80-89 mmHg, but without HTN. The prevalence of undiagnosed HTN in the total population was 26% and was 11% and 40% in the young (≤40-year) and old (>40-year) populations, respectively. The prevalence of PHTN, 40% in the overall population, was nearly the same in the young (39%) and the old population (42%). The risk factor most strongly associated with PHTN and HTN was obesity, showing the highest odds ratio in the overall (PHTN 2.14; 95% CI 1.20-3.81; HTN 2.72; 95% CI 1.53-4.85), the young (PHTN 2.29; 95% CI 1. HTN 2.92;, and the old (PHTN 1.13; 95% CI 0.65-1.96; HTN 1.38; 95% CI 0.79-2.4) populations. Hypertension is a major risk factor for cardiovascular diseases which must not be ignored, especially in the western Indian population.

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Section: Introductionmentioning

confidence: 99%

Prevalence and Predictors of Undiagnosed Hypertension in an Apparently Healthy Western Indian Population

Shukla

Madan

Thakkar

et al. 2015

Advances in Epidemiology

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“…1,2 South Asian ethnicity itself is considered as one of the risk factor of CVD and the prevalence of various cardiovascular risk factors (CVRFs) predisposes this population to premature vascular ageing. 3 Atherosclerosis, formerly known as a disease of lipid storage is actually a complex cardiac condition involving active and chronic inflammatory process. Hypertension, diabetes, addiction, age, gender and hereditary factors all contribute to the progression of atherosclerosis; however inflammatory cells also play a vital role in this process.…”

Section: Introductionmentioning

confidence: 99%

Do circulating blood cell types correlate with modifiable risk factors and outcomes in patients with acute coronary syndrome (ACS)?

Sharma¹,

Shah²,

Patel³

et al. 2015

Indian Heart Journal

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“…A higher estimated vascular age than chronological age has been shown to be associated with components of metabolic syndrome and CV risk profiles in large crosssectional studies of general populations. 15,16 Higher Δage could predict the earlier occurrence of CV events in south Asians. In a randomized trial of 3153 subjects in southern Europeans, informing patients about their CVD risk expressed as the Heart Age tool resulted in a higher reduction in their CVD risk than the traditional methods of Framingham REGICOR risk score after 12 months follow up.…”

Section: Discussionmentioning

confidence: 96%

“…In this study, we reported more extensively the analyses conducted by using the concept of Δage because we wanted to underline the risk related to modifiable factors and to have an index that identifies men in whom such CKD risk factors can be improved. A higher estimated vascular age than chronological age has been shown to be associated with components of metabolic syndrome and CV risk profiles in large cross‐sectional studies of general populations . Higher Δage could predict the earlier occurrence of CV events in south Asians.…”

Section: Discussionmentioning

confidence: 99%

Vascular age is associated with the risk of dialysis or death in chronic kidney disease

Lin

Chan

et al. 2019

Nephrology

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Aim Increased arterial stiffness is associated with progressive renal deterioration and poor clinical outcomes in patients with chronic kidney disease (CKD). Assessment of vascular age as derived from arterial stiffness parameters might be an important clinical marker of cardiovascular risks. The aim of the present study is to evaluate whether the difference (△age) between vascular age and chronological age can predict the risk of reaching dialysis or death in patients with known CKD. Methods This longitudinal study enrolled 94 male Chinese CKD patients, aged 40–62 years. Vascular age was calculated by brachial‐ankle pulse wave velocity, and measured by an ankle‐brachial index‐form device. The study endpoints were the commencement of renal replacement therapy or death. Results After a stepwise multivariate analysis, △age was associated independently with increased urine protein‐to‐creatinine ratio (β = 0.32; P = 0.001) and decreased baseline estimated glomerular filtration rate (β = −0.24; P = 0.008). During a median follow‐up period of 62 (interquartile range = 55–66) months, the 4‐year cumulative incidence of reaching the study endpoint in patients with △age = 0 and △age > 0 year was 4.9% and 25%, respectively (log–rank test, P = 0.009). Multivariate forward Cox regression analysis identified that higher △age (hazard ratio (HR) = 1.05; P = 0.027), lower baseline estimated glomerular filtration rate (HR = 0.93; P < 0.001), and history of cardiovascular disease (HR = 5.90; P = 0.031) were independently associated with progression to commencement of dialysis or death. Conclusion Thus, the assessment of the difference between vascular age and chronological age may provide an alternative method to identify CKD patients at a high risk of progression to dialysis or death.

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Are Gujarati Asian Indians ‘older’ for their ‘vascular age’ as compared to their ‘Chronological age’?

Abstract: The Gujarati Asian Indians are subjected to premature vascular ageing and henceforth routine screening for vascular age and risk factors prevalence is strongly advocated in this ethnic group.

Cited by 18 publications

References 24 publications

Prevalence and Predictors of Undiagnosed Hypertension in an Apparently Healthy Western Indian Population

Prevalence and Predictors of Undiagnosed Hypertension in an Apparently Healthy Western Indian Population

Do circulating blood cell types correlate with modifiable risk factors and outcomes in patients with acute coronary syndrome (ACS)?

Vascular age is associated with the risk of dialysis or death in chronic kidney disease

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