Are health care providers who work with cancer drugs at an increased risk for toxic events? A systematic review and meta-analysis of the literature

Dranitsaris, George; Johnston, Mary; Poirier, Susan; Schueller, Trudi; Milliken, Debbie; Green, Esther; Zanke, Brent W.

doi:10.1191/1078155205jp155oa

Cited by 142 publications

(81 citation statements)

References 28 publications

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“…A meta-analysis pooled the results of five studies 19-21, 24, 25 and found an overall adjusted increased risk of 46% (95% CI = 11%-92%). 28 Only one of these studies 25 occurred after safe handling measures were first recommended in 1985. 29,30 However, since 1985, several exposure studies still report drug contamination on work surfaces in pharmacies and patient rooms.…”

Section: Commentmentioning

confidence: 99%

Occupational exposures among nurses and risk of spontaneous abortion

Lawson

Rocheleau

Whelan

et al. 2012

American Journal of Obstetrics and Gynecology

166

106

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Objective-We investigated self-reported occupational exposure to antineoplastic drugs, anesthetic gases, antiviral drugs, sterilizing agents (disinfectants), and X-rays and the risk of spontaneous abortion in U.S. nurses.Study Design-Pregnancy outcome and occupational exposures were collected retrospectively from 8,461 participants of the Nurses' Health Study II. Of these, 7,482 were eligible for analysis using logistic regression.Results-Participants reported 6,707 live births, and 775 (10%) spontaneous abortions (<20 weeks). After adjusting for age, parity, shift work, and hours worked, antineoplastic drug exposure was associated with a 2-fold increased risk of spontaneous abortion, particularly with early spontaneous abortion before the 12 th week, and 3.5-fold increased risk among nulliparous women. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Exposure to sterilizing agents was associated with a 2-fold increased risk of late spontaneous abortion (12-20 weeks), but not with early spontaneous abortion. HHS Public AccessConclusion-This study suggests that certain occupational exposures common to nurses are related to risks of spontaneous abortion.

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Section: Commentmentioning

confidence: 99%

Occupational exposures among nurses and risk of spontaneous abortion

Lawson

Rocheleau

Whelan

et al. 2012

American Journal of Obstetrics and Gynecology

166

106

View full text Add to dashboard Cite

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“…1 Over the past 4 decades, there have been considerable advances in understanding the health outcomes associated with occupational exposure to antineoplastic drugs, including acute effects, 2,3 reproductive toxicities, [4][5][6] and carcinogenic potential. 5,7 Recent evidence has confirmed that a range of Canadian health care workers are at risk of exposure.…”

Section: Discussionmentioning

confidence: 99%

Causes of Health Care Workers’ Exposure to Antineoplastic Drugs: An Exploratory Study

Hon

Abusitta

2016

CJHP

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“…The effects have occurred at lower doses as compared to those administered to patients [55]. A meta-analysis reported increase in the rate of spontaneous abortions but not that of congenital malformations and still births [57]. Children of nurses handling chemotherapeutic drugs for a long period showed learning disabilities in another study [58].…”

Section: Hazards Of Exposure To Cytotoxic Agentsmentioning

confidence: 99%

Safety considerations for Health care Workers involved in Cytoreductive Surgery and Perioperative chemotherapy

Bhatt

Mittal

Gopinath³

2016

Indian J Surg Oncol

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The combined modality treatment of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) has gained worldwide acceptance for management of selected patients with peritoneal metastases from various cancers. Cytoreductive surgery is performed with the goal of removing all macroscopic disease and is coupled with perioperative chemotherapy (POC) in the form of HIPEC with or without EPIC (early postoperative intraperitoneal chemotherapy) to deal with the microscopic residual disease. These treatments entail the use of cytotoxic drugs in the operation theatre or in the intensive care unit where they are not commonly used and put the healthcare workers participating in the treatment at risk of exposure. CRS is performed with high voltage electrocautery generating a large amount of surgical smoke which is inhaled by the involved personnel and has potential health hazards. This article outlines the safety measures to be taken while performing CRS and POC.

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Are health care providers who work with cancer drugs at an increased risk for toxic events? A systematic review and meta-analysis of the literature

Cited by 142 publications

References 28 publications

Occupational exposures among nurses and risk of spontaneous abortion

Occupational exposures among nurses and risk of spontaneous abortion

Causes of Health Care Workers’ Exposure to Antineoplastic Drugs: An Exploratory Study

Safety considerations for Health care Workers involved in Cytoreductive Surgery and Perioperative chemotherapy

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