Are Helicobacter pylori Infection and Fucoidan Consumption Associated with Fucoidan Absorption?

Abstract

We examined the associations of Helicobacter pylori and mozuku consumption with fucoidan absorption. Overall, 259 Japanese volunteers consumed 3 g fucoidan, and their urine samples were collected to measure fucoidan values and H. pylori titers before and 3, 6, and 9 h after fucoidan ingestion. Compared to the basal levels (3.7 ± 3.4 ng/mL), the urinary fucoidan values significantly increased 3, 6, and 9 h (15.3 ± 18.8, 24.4 ± 35.1, and 24.2 ± 35.2 ng/mL, respectively) after fucoidan ingestion. The basal fucoidan levels were significantly lower in H. pylori-negative subjects who rarely ate mozuku than in those who regularly consumed it. Regarding the ΔMax fucoidan value (highest value − basal value) in H. pylori-positive subjects who ate mozuku at least once a month, those aged ≥40 years exhibited significantly lower values than <40 years old. Among subjects ≥40 years old who regularly consumed mozuku, the ΔMax fucoidan value was significantly lower in H. pylori-positive subjects than in H. pylori-negative ones. In H. pylori-positive subjects who ate mozuku at least once monthly, basal fucoidan values displayed positive correlations with H. pylori titers and ΔMax fucoidan values in subjects <40 years old. No correlations were found in H. pylori-positive subjects who ate mozuku once every 2–3 months or less. Thus, fucoidan absorption is associated with H. pylori infection and frequency of mozuku consumption.

Pharmacokinetics of Marine-Derived Drugs

“…Unfortunately, the authors did not provide details about fucoidan’s molecular weight, sulfate content, or monosaccharides composition. To understand the effect of Helicobacter pylori on fucoidan absorption, the group of 259 subjects consumed 3 g mozuku fucoidan in a health drink [ 170 ]. Fucoidan was analyzed in urine.…”

Fucoidans as Scientifically and Commercially Important Algal Polysaccharides

“…Typical bioactivities of fucoidans are antibacterial and antioxidant. Fucoidans in this Special Issue exhibited antibacterial effect against Helicobacter pylori infection [ 22 ] and antioxidant effect against oxidative stress [ 23 ]. Fucoidans can be effective on skin.…”