Are herbicide mixtures unaffected by resistance? A case study with <i>Lolium rigidum</i>

Busi, Roberto; Beckie, Hugh J.

doi:10.1111/wre.12453

Cited by 22 publications

(31 citation statements)

References 57 publications

(112 reference statements)

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“…It would be wise to rotate dinitroaniline herbicides like trifluralin with herbicides that might not be readily metabolized by dinitroaniline-metabolizing enzymes (e.g., prosulfocarb, pyroxasulfone) ( Busi et al, 2017 , 2020a ). Computer simulation modeling, as well as the screening work with many field L. rigidum populations showed that mixtures of pre-emergency herbicides (e.g., trifluralin/prosulfocarb, trifluralin/pyroxasulfone, trifluralin/triallate) can delay the onset of resistance and mitigate the existing levels of resistance ( Busi and Beckie, 2020 ; Busi et al, 2020b ). Third, co-existence of TSR and NTSR in the same populations suggest the importance of the integrated weed management (IWM) incorporating non-chemical weed management tactics (harvest weed seed control, crop rotation, etc.)…”

Section: Implications For Dinitroaniline Resistance Managementmentioning

confidence: 99%

Dinitroaniline Herbicide Resistance and Mechanisms in Weeds

Chen

Patterson

et al. 2021

Front. Plant Sci.

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Dinitroanilines are microtubule inhibitors, targeting tubulin proteins in plants and protists. Dinitroaniline herbicides, such as trifluralin, pendimethalin and oryzalin, have been used as pre-emergence herbicides for weed control for decades. With widespread resistance to post-emergence herbicides in weeds, the use of pre-emergence herbicides such as dinitroanilines has increased, in part, due to relatively slow evolution of resistance in weeds to these herbicides. Target-site resistance (TSR) to dinitroaniline herbicides due to point mutations in α-tubulin genes has been confirmed in a few weedy plant species (e.g., Eleusine indica, Setaria viridis, and recently in Lolium rigidum). Of particular interest is the resistance mutation Arg-243-Met identified from dinitroaniline-resistant L. rigidum that causes helical growth when plants are homozygous for the mutation. The recessive nature of the TSR, plus possible fitness cost for some resistance mutations, likely slows resistance evolution. Furthermore, non-target-site resistance (NTSR) to dinitroanilines has been rarely reported and only confirmed in Lolium rigidum due to enhanced herbicide metabolism (metabolic resistance). A cytochrome P450 gene (CYP81A10) has been recently identified in L. rigidum that confers resistance to trifluralin. Moreover, TSR and NTSR have been shown to co-exist in the same weedy species, population, and plant. The implication of knowledge and information on TSR and NTSR in management of dinitroaniline resistance is discussed.

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Section: Implications For Dinitroaniline Resistance Managementmentioning

confidence: 99%

Dinitroaniline Herbicide Resistance and Mechanisms in Weeds

Chen

Patterson

et al. 2021

Front. Plant Sci.

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“…Simulation models and experimental evidence indicate that mixtures of chemicals each applied at label rates (or sequential application to the same weed population cohort) are more effective than rotations in mitigating or managing resistance (e.g. Beckie and Reboud 15 ; Busi et al 16 ; Busi and Beckie 17 ; Fig. 1).…”

Section: Herbicide Resistance Managementmentioning

confidence: 99%

“…19 Even though a herbicide-resistant weed may be resistant to each component in a mixture, recent research has found that it may be controlled by a mixture of both components applied at label rates for reasons that are still unclear. 17…”

Section: Herbicide Resistance Managementmentioning

confidence: 99%

“…While we have outlined general strategies for mitigating or managing resistance, we are now at a point where increasing complex cross-resistance or multiple resistance in target populations demands more prescriptive or customized solutions tailored to the resistance profile of the population. 17,62 Accordingly, regular resistance surveillance and testing will become increasingly important to inform the most efficient and effective management strategies. 7 This goal will be greatly facilitated by emerging rapid and accurate diagnostic biochemical, molecular, genomic, and/or phenotypic assays.…”

Section: There Are More Common Than Different Strategiesmentioning

confidence: 99%

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Herbicide resistance management strategies: how do they compare with those for insecticides, fungicides and antibiotics?

Beckie

Busi

Lopez‐Ruiz

et al. 2021

Pest Management Science

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Herbicides are the largest category of pesticides used in global agriculture, which is reflected in the rate of increase in the number of unique cases of herbicide-resistant weed biotypes since the late 1950s. Recommended herbicide resistance management strategies and tactics have evolved over the past 50 years through cumulative research and experience and have been regularly reviewed. Nevertheless, new perspectives may be gained by viewing current recommended strategies through the lens of insecticide, fungicide, and antibiotic resistance management. What commonalities exist and what is the basis for disparate strategies? Although pesticide and antibiotic mixtures (or combinations) are generally more effective than rotations (or alternations) in mitigating or managing resistance, the latter strategy is often employed because of greater ease of implementation and other reasons. We conclude that there are more common than different strategies for mitigating or managing pesticide and antibiotic resistance. Overall, a reduction in selection pressure for resistance evolution through diverse multitactic management programmes, and disruption or mitigation of the dispersal or transmission of problematic genotypes are needed to sustain the longevity of current and future mode-of-action products for crop and human health protection.

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“…[36][37][38][39] Modeling simulations have often supported this hypothesis of a lower target-site resistance risk with the use of mixtures due to the assumption that the selection of resistance directly correlates to the initial frequency of resistance alleles versus the multiplicative product of two initial resistance allele frequencies. [40][41][42][43] In a recent study, 44 the frequency of target-site resistance in L. rigidum to Group 1 post-emergence herbicides such as diclofop-methyl (>90%) or clethodim (>60%) can be significantly minimized (4-6-fold) by the application of a mixture of clethodim and butroxydim (Fig. 2).…”

Section: Improving Resistance Diagnosis and Testingmentioning

confidence: 99%

Can new herbicide discovery allow weed management to outpace resistance evolution?

Gaines

Busi

Küpper

2021

Pest Management Science

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While herbicides are the most effective and widely adopted weed management approach, the evolution of multiple herbicide resistance in damaging weed species threatens the yield and profitability of many crops. Weeds accumulate multiple resistance mechanisms through sequential selection and/or gene flow, with long-range and international transport of herbicide-resistant weeds proving to be a serious issue. Metabolic resistance mechanisms can confer resistance across multiple sites of action and even to herbicides not yet discovered. When a new site of action herbicide is introduced to control a key driver weed, it likely will be one of very few effective available herbicide options for that weed in a specific crop due to the continuous use of herbicides over the years and the resulting accumulation of resistance mechanisms, placing it at even higher risk to be rapidly lost to resistance due to the high selection pressure it will experience. The number of available, effective herbicides for certain driver weeds is decreasing over time because the rate of resistance evolution is faster than the rate of new herbicide discovery. Effective monitoring for species movement and diagnostics for resistance should be deployed to rapidly identify emerging resistance to any new site of action. While innovation in herbicide discovery is urgently needed to combat the pressing issue of resistance in weeds, the rate of selection for herbicide resistance in weeds must be slowed through changes in the patterns of how herbicides are used.

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Are herbicide mixtures unaffected by resistance? A case study with Lolium rigidum

Cited by 22 publications

References 57 publications

Dinitroaniline Herbicide Resistance and Mechanisms in Weeds

Dinitroaniline Herbicide Resistance and Mechanisms in Weeds

Herbicide resistance management strategies: how do they compare with those for insecticides, fungicides and antibiotics?

Can new herbicide discovery allow weed management to outpace resistance evolution?

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