Are In-Vitro Platelet Function Tests Useful in Predicting Blood Loss Following Open Heart Surgery?

Abstract

Although a significant correlation was found between blood loss and the PFA-100 IVBT, the practical value of these tests in the clinical situation is limited due to a great variability in individual results.

Platelet concentrates transfusion in cardiac surgery and platelet function assessment by multiple electrode aggregometry

“…Other methods of assessment of platelet function, like lumi-aggregometry 6 and PFA-100 s (Dade Behring, Miami, FL), also showed limited or no predictive value for post-operative blood loss. [8][9][10] PFA-100 s , an in vitro simulation of the bleeding time, 7 showed only limited predictive value for bleeding related to platelet dysfunction in cardiac surgery. This may be explained by the method being dependent both on the concentration and activity of plasmatic factors, such as the von Willebrand factor, and on platelet activity.…”

“…The application of methods that assess platelet function in whole blood has been investigated, with controversial reports on their predictive value for clinical endpoints such as bleeding or transfusion requirements. [6][7][8][9][10][11][12][13][14] Multiple electrode platelet aggregometry (MEA) is a whole-blood impedance aggregometry method that allows the assessment of platelet function both in the laboratory and in the near-patient setting. The method requires no centrifugation steps and the measurements are performed in single-use test cells.…”

Clinical Relevance and Practical Value of Platelet Function Assessment Using Multiple Electrode Aggregometry during Extracorporeal Circulation

“…Our working group has recently published studies evaluating predictability of bleeding complications by using MEA both preoperatively [3] and intraoperatively [4]. Even though we reported positive results with calculated receiver operating curve cut-off values, the fact is that the literature reveals controversial data on predictability of bleeding complications using platelet function testing [5][6][7]. Therefore, further efforts to elucidate this field are warranted.…”

PFA-100®: Globaltest der primären Hämostase?/PFA-100®: Global Test for Primary Haemostasis?

“…Blutungsrisiko [42]. Zwei anderen Studien zufolge, die den Blutverlust unter koronarer Bypass-Op zum Gegenstand hatten, scheinen verla Èngerte Verschlusszeiten einen drohenden Blutverlust nicht ausreichend veraussagen zu ko Ènnen [43,44].…”