Are Inherited Combined Thrombophilia Mutations a Causative or an Additive Factor in Recurrent Venous Thrombotic Accidents?

Benefits of prescribing low-dose digoxin in atrial fibrillation

“…These patients should undergo thrombophilia testing (e.g., protein C, protein S, antithrombin, lupus anticoagulant, and activated protein C resistance). 19 However, AF patients on NOACs/DOACs (FIIa and FXa inhibitors) may cause false results, and therefore, such patients need to be carefully assessed. 53 As one of the goals of AF therapy is to prevent deterioration in patients' QOL, administering pertinent questionnaires can help identify changes in QOL.…”

“…17 AF accounts for almost one-third of all stroke cases caused by thromboembolic events (TE), and the mortality rate in such cases is higher when compared with strokes of other etiologies. 18,19 Furthermore, the severity of stroke is higher and the degree of debilitation in the AF patients is much worse than the non-AF stroke patients. 20,21 Silent cerebral infarctions (SCI's) are a common feature in AF patients, putting them at a greater risk of developing cognitive impairment, disabilities, and stroke events in the future.…”

Optimizing pharmacologic thromboprophylaxis use in pediatric orthopedic surgical patients through implementation of a perioperative venous thromboembolism risk screening tool

“…8,[11][12][13] Additionally, the presence of a personal or family history of thrombosis or thrombophilia has also been established as a risk factor. 14,15 Despite limited data existing in the literature, orthopedic surgical risk factors such as complex and prolonged surgery, surgeries focused on the spine and hip, and surgeries which result in altered mobility have been identified. 7,[16][17][18][19][20] Aside from financial considerations, thromboprophylaxis administration also introduces inherent risks to the patient, with the most notable adverse outcomes being bleeding complications.…”

“…A range of risk factors for VTE and high‐risk pediatric subgroups have been identified through recent studies, detailing risk factors such as post‐pubertal age, altered mobility, obesity, active cancer, active inflammatory or metabolic disorder, major trauma, infection, estrogen therapy, smoking, admission to an intensive care unit, and the presence of a central venous catheter 8,11–13 . Additionally, the presence of a personal or family history of thrombosis or thrombophilia has also been established as a risk factor 14,15 . Despite limited data existing in the literature, orthopedic surgical risk factors such as complex and prolonged surgery, surgeries focused on the spine and hip, and surgeries which result in altered mobility have been identified 7,16–20 …”