Are lesion features reproducible between 18F-FDG PET/CT images when acquired on analog or digital PET/CT scanners?

Constantino, Cláudia S.; Oliveira, Francisco P. M.; Silva, Mariana; Oliveira, Carla; Castanheira, Joana; Silva, Ângelo; Vaz, Sofia; Vieira, Pedro; Costa, Durval C.

doi:10.1007/s00330-020-07390-8

Cited by 13 publications

(13 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The development of new PET/CT scanners and technical features could influence the choice of the best SUVmax threshold to detect RT and this topic needs to be better analyzed, especially in the future with the increased availability of digital PET/CT scanners [36].…”

Section: Discussionmentioning

confidence: 99%

The Role of 2-[18F]-FDG PET/CT in Detecting Richter Transformation in Chronic Lymphocytic Leukemia: A Systematic Review

et al. 2021

View full text Add to dashboard Cite

Richter transformation (RT) is a condition wherein B cell chronic lymphocytic leukemia (CLL) transforms into a more aggressive lymphoma variant. The incidence and the significance of RT detected by 2-[18F]-FDG PET/CT is a clinical challenge and it is not widely investigated in the literature. The aim of this systematic review was to analyze published data about the potential role of 2-[18F]-FDG PET/CT in detecting RT. A comprehensive computer literature search of the PubMed/MEDLINE, Embase and Cochrane library databases was conducted up to December 2020. Thirteen studies (1336 patients with CLL) were selected. The maximum standardized uptake value (SUVmax) was the most common metabolic parameter used to detect RT. An SUVmax of 5 had an average overall sensitivity of 87% (range: 71–96%), an average overall specificity of 49% (range: 4–80%), an average positive predictive value of 41% (range: 16–53%) and an average negative predictive value of 84% (range: 33–97%). Other metabolic variables were only marginally investigated, with promising results. 2-[18F]-FDG PET/CT imaging may play an important role in the detection of RT in CLL, based on the high metabolic activity of the nodal lesions that transformed into aggressive lymphomas. 2-[18F]-FDG PET/CT has high negative predictive value for evaluating RT.

show abstract

Section: Discussionmentioning

confidence: 99%

The Role of 2-[18F]-FDG PET/CT in Detecting Richter Transformation in Chronic Lymphocytic Leukemia: A Systematic Review

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Furthermore, the introduction of digital PET machines has resulted in increased sensitivity with a relative increased FDG uptake as compared to analog systems. In a recent prospective single-center study, Constantino et al (16) showed higher lesion SUVs with digital systems in a head-to-head comparison with analog systems. However, when they applied specific protocols' reconstructions, the relative difference was minimized between analog and digital PET system (16).…”

Section: Variants Artifacts and Pitfallsmentioning

confidence: 97%

“…In a recent prospective single-center study, Constantino et al (16) showed higher lesion SUVs with digital systems in a head-to-head comparison with analog systems. However, when they applied specific protocols' reconstructions, the relative difference was minimized between analog and digital PET system (16).…”

Section: Variants Artifacts and Pitfallsmentioning

confidence: 97%

Imaging Lymphoma With F-18 Fluorodeoxyglucose PET-CT: What Should Be Known About Normal Variants, Pitfalls, and Artifacts?

Vangu

Momodu

2022

Front. Nucl. Med.

View full text Add to dashboard Cite

18F fluorodeoxyglucose ([F-18] FDG) PET-CT has gained popularity in the management of many types of malignancies. Today, imaging patients with lymphoma using of [F-18] FDG PET-CT not only is considered as a state-of-the-art tool but also has taken a central place for therapeutic decisions. In fact, accurate staging at diagnosis is imperative to prevent under treatment of individuals with advanced disease. In Hodgkin's lymphoma, in particular, the current role of interim [F-18] FDG PET imaging goes beyond speculations in the adaptation of different therapeutic strategies. Therefore, the use of such a critical imaging modality should go hand in hand with sound interpretation that provides accurate results. As the number patients referred for PET-CT continues to increase, imaging specialists should remain aware of the inherent limitations linked to the integrated imaging system that may introduce potential pitfalls related to the machine or the administered [F-18] FDG. Knowledge of the normal physiologic biodistribution of [F-18] FDG, its physiologic variants, and of all the potential pitfalls and artifacts is paramount to avoid misinterpretation. Recognition of the limitations of [F-18] FDG PET-CT will increase the confidence of practicing clinicians on the modality and impact positively on the management of patients. In this article, we will review the normal physiological variants, technical artifacts, and diagnostic pitfalls in lymphoma. Highlighting the limitations of [F-18] FDG PET-CT imaging should warn interpreting specialists to find measures that mitigate them and improve reporting results.

show abstract

“…There is also the variability between observers as the measurement of this “most avid” pixel in a tumour volume is dependent on the size, shape and placement of the region of interest (ROI) 6 . In addition, these measurements are not transferable between machines, institutions or even necessarily repeatable from day to day on the same patient 7 …”

Section: Introductionmentioning

confidence: 99%

“…6 In addition, these measurements are not transferable between machines, institutions or even necessarily repeatable from day to day on the same patient. 7 Volumetric measurements of tumour activity for reporting are becoming more common in human medicine and are potentially more representative of the metabolic burden of a tumour. Some of the commonly reported parameters to date include the metabolic tumour volume (MTV) and the total lesion glycolysis (TLG).…”

mentioning

confidence: 99%

The prognostic significance of metabolic tumour volume and total lesion glycolysis for dogs staged for appendicular osteosarcoma with fluorine‐18 fluorodeoxyglucose positron emission tomography/computed tomography

Griffin

Brody

Lee

2021

Vet Comparative Oncology

View full text Add to dashboard Cite

Metabolic tumour volumes (MTV) and total lesion glycolysis (TLG) are metabolic parameters that are becoming more commonly reported in human medicine to quantify tumours detected on fluorine‐18 fluorodeoxyglucose positron emission tomography/computed tomography (18F‐FDG PET/CT). In this retrospective study dogs afflicted with appendicular osteosarcoma that were staged with 18F‐FDG PET/CT had MTV and TLG at a variety of set and fixed thresholds calculated by two observers. These values, along with SUVmax, were evaluated for prognostic significance in this population of dogs. There was excellent correlation between two observers for all values. Multiple volumetric parameters were significantly associated with survival. SUVmax had the highest sensitivity for survival and TLG at 2.5 SUV*cm3 had the highest specificity for prediction of survival based on ROC calculations. The SUVmax, MTV at 2.5 SUV and TLG at 2.5 SUV*cm3 were significantly different between dogs that survived more than or less than 1 year. This study is the first of its kind in veterinary medicine that retrospectively evaluated volumetric tumour values for prognostic significance and may provide a basis for standardized method of reporting 18F‐FDG PET/CT results.

show abstract

Are lesion features reproducible between 18F-FDG PET/CT images when acquired on analog or digital PET/CT scanners?

Cited by 13 publications

References 19 publications

The Role of 2-[18F]-FDG PET/CT in Detecting Richter Transformation in Chronic Lymphocytic Leukemia: A Systematic Review

The Role of 2-[18F]-FDG PET/CT in Detecting Richter Transformation in Chronic Lymphocytic Leukemia: A Systematic Review

Imaging Lymphoma With F-18 Fluorodeoxyglucose PET-CT: What Should Be Known About Normal Variants, Pitfalls, and Artifacts?

The prognostic significance of metabolic tumour volume and total lesion glycolysis for dogs staged for appendicular osteosarcoma with fluorine‐18 fluorodeoxyglucose positron emission tomography/computed tomography

Contact Info

Product

Resources

About