This paper aims to investigate the effect innovation barriers has on the innovation orientation in the Syrian construction firms in the period of the war years. The effect of 8 different barriers were investigated: Technical, Financial, Process, Psychological, Management, Culture, Environmental and Governmental barriers. Questionnaire data were collected from a sample of 306 architects and Civil engineers from large, small and medium sized construction firms, which operated in Syria within the past 6 years of the war. The results from total sample community confirmed only 9 hypotheses out of 16, confirming the full significant effect of the Technical, Financial, Process and Psychological Barriers had on both innovation orientations-(Creation & Adoption), Whereas, environmental Barrier significant effect only on the Creation innovation orientation. This paper illustrates the assessment of the measurement and structural model using Partial Least Squares-Structural Equation Modelling PLS-SEM (Warp PLS 6.0 software). The study contributes theoretically and methodologically to the innovation barriers literature in specific and innovation literature in general. Moreover, the result can assist the local firms and authorities in understanding the barriers structure and guide them for future developments and improvements that are disparately needed for the era of the rebuilding the country after the war.