Are Low Total Serum Antioxidant Status and Elevated Levels of C-Reactive Protein and Monocyte Chemotactic Protein-1 Associated With Cardiac Syndrome X?

On, Young Keun; Park, Rojin; Hyon, Min Su; Kim, Sung Koo; Kwon, Young Joo

doi:10.1253/circj.69.1212

Cited by 22 publications

(14 citation statements)

References 20 publications

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“…Low level of antioxidants, or inhibition of the antioxidant enzymes, cause oxidative stress and may damage or kill cells 28 . Thus in the present study, the increase in oxidative stress markers such as MDA levels and the decrease in antioxidant markers such as FRAP and GSH and SOD activity correlated with the presence of CSX, supports the reports regarding the role of oxidative stress in the pathogenesis of CSX 22,23,29 . However, the role of oxidative stress in patient with CSX has not been fully elucidated and we could not find many data in literature about the oxidative stress statusparticularly stated parameters-in CSX patients.…”

Section: Discussionsupporting

confidence: 91%

“…Oxidative stress is thought to be linked to certain cardiovascular diseases. In the literature, there are only two studies revealing the association between CSX and oxidative stress that have shown decreased total antioxidant levels in CSX patients 22,23 . In this study, lipid peroxidation was evaluated by measuring of MDA, which results from free radical damage to the membrane components of the cells and can also deactivate membrane transporters, by forming intra-and inter-molecular crosslinks 24,25 .…”

Section: Discussionmentioning

confidence: 99%

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Oxidative stress status in patients with cardiac syndrome X

Seydi-Shirvani¹,

Rasmi

Seyyed-Mohammadzad³

et al. 2012

ScienceAsia

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Cardiac syndrome X (CSX) is characterized by chest pain, typical angina pectoris, abnormal exercise test result and normal coronary arteries. Microvascular dysfunction and enhanced oxidative stress are the mechanisms suspected to play an important role in the pathogenesis of CSX. Thus we aimed to evaluate the oxidative stress status of 28 patients with CSX (14 male/14 female, mean age 49.5 ± 9.3 years) and 24 age-and gender-matched healthy controls (10 male/14 female, mean age 45.6 ± 5.7 years). Blood samples were drawn for measurement of malodialdehyde (MDA), as a marker of lipid peroxidation, glutathione (GSH) and superoxide dismutase (SOD) activity, as antioxidant markers and ferric reducing ability of plasma (FRAP), as a marker of total antioxidant capacity. There was significant increase in the levels of MDA in CSX patients comparing to controls (3.8 ± 0.12 vs 3.3 ± 0.14 mM, respectively; p = 0.006). But the levels of FRAP in CSX patients were significantly lower than those controls (504 ± 19 vs 568 ± 26 µM, respectively; p = 0.046). Also, GSH levels and SOD activity in patients were significantly lower than those of the controls (GSH: 133.6 ± 5.4 vs 152.5 ± 7.8 mmol/g Hb, p = 0.048; SOD: 386 ± 34 vs 578 ± 38 U/g Hb, p = 0.0001). It may be concluded that there is systemic oxidative stress in CSX patients. Considerable changes of antioxidant concentrations, indicating a compensatory mechanism to cope with increased oxidative stress in CSX patients and the body's antioxidant defence mechanisms try to minimize oxidative stress damage.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Oxidative stress status in patients with cardiac syndrome X

Seydi-Shirvani¹,

Rasmi

Seyyed-Mohammadzad³

et al. 2012

ScienceAsia

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show abstract

“…In the literature, there are two studies revealing the relationship between CSX and oxidative stress. Both of them indicated total antioxidant status levels reduced in CSX cases [19,20]. For the first time in the literature, we have shown increased activity of MPO, levels of MDA, and decreased activity of SOD, and levels of NOx in cases with CSX.…”

Section: Before Aftermentioning

confidence: 59%

The effect of nebivolol treatment on oxidative stress and antioxidant status in patients with cardiac syndrome-X

Erdamar

Şen

Tavıl

et al. 2009

Coronary Artery Disease

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“…It has been suggested that chronic inflammation is of central importance in atherosclerosis, 31,32 and it has been shown that regular and chronic exercise can suppress overt and subclinical inflammation, 3,34,35 based on the fact that atherosclerosis can be considered as a generalized manifestation of an inflammatory disease. 21 Therefore, we and other investigators have already reported that experimental atherosclerosis in apoE-deficient mice is markedly suppressed by administration of the Fc portion of immunoglobulin, possibly by an antiinflammatory action via the inhibitory Fc receptor IIB.…”

Section: Study Limitationsmentioning

confidence: 99%

Exercise Training Reduces Severity of Atherosclerosis in Apolipoprotein E Knockout Mice via Nitric Oxide

Shimada

Kishimoto

Okabe

et al. 2007

Circ J

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xercise is deters the development of cardiovascular disease. Its antiatherogenic effects have been described in different animal models, 1,2 and exercise can also influence risk factors that are associated with cardiovascular diseases (ie, hypertension, diabetes mellitus, obesity, hyperlipidemia, and endothelial dysfunction). [1][2][3] However, the mechanisms by which exercise is beneficial with regard to cardiovascular diseases are still unknown. Enzymes associated with antioxidant defense, such as manganese superoxide dismutase, endothelial nitric oxide synthase (eNOS), heme oxygenase, and catalase, 4-8 can be induced by oxidants in cell culture studies. There is significant evidence to indicate that exercise training increases coronary endothelium-dependent relaxation, 9,10 and that these effects are associated with increased NO production 9-12 and eNOS gene expression. 12,13 In the present study, using apolipoprotein-E (apoE)-deficient mice, we looked for evidence of induction of fatty and fibrofatty streaks in the arterial wall and the lessening of atherosclerotic lesions by exercise. We also investigated the effect of N G -nitro-L-arginine methylester (L-NAME) supplementation, an inhibitor of NOS, on atherosclerotic lesions in exercise-trained mice. Circulation Journal Vol.71, July 2007 Methods Experimental AtherosclerosisThe apoE-deficient 129ola × C57BL/6 hybrid mice were the generous gift of Dr Edward M. Rubin (University of California, Berkeley, CA, USA). They were mated with C57BL/6 mice to produce F1 hybrids. The F1 apoE +/-mice were then backcrossed to C57BL/6 mice for 10 generations. Mice homogeneous for the apoE-null allele on a C57BL/6 background were subsequently generated. Male mice were used in the present experiments. The mice were kept in a temperature-controlled facility on a 14:10-h light -dark cycle with free access to food and water.After being weaned at 4 weeks of age, the mice were fed a normal chow diet (Oriental Yeast) until 6 weeks of age, when they were switched to a high-fat diet (HFD) containing 20% fat and 0.3% cholesterol as previously described. 14 We performed the animal experiments in accordance with the Declaration of Helsinki, and they were approved by the institutional ethics committee for animal experiments of Kyoto University. Exercise ProtocolAt 6 weeks of age, the mice underwent an exercise protocol of swimming in a hot bath (37°C) for 30 min per day 3 times per week for 8 weeks. Exercise time was gradually increased up to 45 min in the first 2 weeks. These mice were divided into the following 4 groups, which on day 0 received HFD with and without L-NAME supplementation: HFD alone; n=9, HFD + Swimming; n=9, HFD + L-NAME; n=8, HFD + Swimming + L-NAME; n=9. L-NAME (100 g/ml) was administered orally via the drinking water 15 and daily fluid consumption was monitored. The estimated dose of L-NAME (25 mg·kg -1 ·body weight -1 ·day -1 ) was based on fluid consumption and drug concentration. The oral route Circ J 2007; 71: 1147 -1151 (Received April 5, 2006 revised manuscr...

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Are Low Total Serum Antioxidant Status and Elevated Levels of C-Reactive Protein and Monocyte Chemotactic Protein-1 Associated With Cardiac Syndrome X?

Cited by 22 publications

References 20 publications

Oxidative stress status in patients with cardiac syndrome X

Oxidative stress status in patients with cardiac syndrome X

The effect of nebivolol treatment on oxidative stress and antioxidant status in patients with cardiac syndrome-X

Exercise Training Reduces Severity of Atherosclerosis in Apolipoprotein E Knockout Mice via Nitric Oxide

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