Are Male Reproductive Disorders a Common Entity?

Boisen, Kirsten A; Main, K. M.; Meyts, Ewa Rajpert‐De; Ne, Skakkebæk

doi:10.1111/j.1749-6632.2001.tb03990.x

Cited by 79 publications

(46 citation statements)

References 72 publications

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“…The male fertility phenotype of the Osteocalcin−/− mice resembled closely a human condition called peripheral testicular failure [45][46][47][48]. This was an incentive to search for mutation either in Osteocalcin or in Gprc6a in patients affected by this disease.…”

Section: Identification Of Gprc6a As An Osteocalcin Receptor In Mice mentioning

confidence: 94%

An Overview of the Metabolic Functions of Osteocalcin

Wei

Karsenty

2015

Curr Osteoporos Rep

101

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A recent unexpected development of bone biology is that bone is an endocrine organ regulating a growing number of physiological processes. One of the functions regulated by bone through the hormone osteocalcin is glucose homeostasis. In this overview, we will explain why we hypothesized that bone mass and energy metabolism should be subjected to a coordinated endocrine regulation. We will then review the experiments that revealed the endocrine function of osteocalcin and the cell biology events that allow osteocalcin to become a hormone. We will also illustrate the importance of this regulation to understand whole-body glucose homeostasis in the physiological state and in pathological conditions. Lastly, we will mention epidemiological and genetic evidence demonstrating that this function of osteocalcin is conserved in humans.

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Section: Identification Of Gprc6a As An Osteocalcin Receptor In Mice mentioning

confidence: 94%

An Overview of the Metabolic Functions of Osteocalcin

Wei

Karsenty

2015

Curr Osteoporos Rep

101

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“…Testicular cancer represents the most severe degree of dysgenesis, whereas CIS is a less severe form of the testicular dysgenesis syndrome. 38 Fifty percent of patients diagnosed with CIS of the testis develop invasive testicular cancer within 5 years of diagnosis. 26 It is thought that all patients who harbour CIS cells at puberty will eventually develop testicular cancer.…”

Section: Incidence Trendsmentioning

confidence: 99%

“…Carcinoma in situ (CIS) of the testis is a distinct histologic pattern preceding the development of seminomatous and nonseminomatous germ-cell tumours of the testis. 37 The link between testicular cancer and CIS, which appears to precede the occurrence of testicular cancer, may be related to a condition referred to as testicular dysgenesis, 38 which occurs in utero with varying levels of severity. Testicular cancer represents the most severe degree of dysgenesis, whereas CIS is a less severe form of the testicular dysgenesis syndrome.…”

Section: Incidence Trendsmentioning

confidence: 99%

Epidemiology of testicular cancer: An overview

Garner

Turner

Ghadirian

et al. 2005

Intl Journal of Cancer

244

191

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Testicular cancer is a rare disease, accounting for 1.1% of all malignant neoplasms in Canadian males. Despite the low overall incidence of testicular cancer, it is the most common malignancy among young men. The incidence rate of testicular cancer has been increasing since the middle of the 20th century in many western countries. However, the etiology of testicular cancer is not well understood. A search of the peer-reviewed literature was conducted to identify important articles for review and inclusion in this overview of the epidemiology of testicular cancer. Most of the established risk factors are related to early life events, including cryptorchidism, carcinoma in situ and in utero exposure to estrogens. Occupational, lifestyle, socioeconomic and other risk factors have demonstrated mixed associations with testicular cancer. Although there are few established risk factors for testicular cancer, some appear to be related to hormonal balance at various life stages. Lifestyle and occupational exposures occurring later in life may play a role in promoting the disease, although they are not likely involved in cancer initiation. In addition to summarizing the current epidemiologic evidence on risk factors for testicular cancer, we suggest future research directions that may elucidate the etiology of testicular cancer. ' 2005 Wiley-Liss, Inc.Over the last 30 years, many studies have sought to discover factors associated with the development and promotion of testicular cancer. At present, however, there are few well-established risk factors for this disease, most notably cryptorchidism and age. For the most part, the etiology of testicular cancer remains unknown.This article provides an overview of risk factors that have been associated with testicular cancer to date. The purpose of this overview is to summarize the scientific literature on the epidemiology of testicular cancer, thereby providing a guide for future research that will advance our knowledge of testicular cancer etiology. Our overview is based on a detailed literature search dating to the late 1960s that was carried out through electronic databases and Medline. The publications considered in this overview are reliable scientific articles on the etiology of testicular cancer from different parts of the world. Incidence trendsThe worldwide incidence of testicular cancer has doubled over the last 40 years.1 In most countries, testicular cancer is rare, with an age-standardized incidence rate ranging from about 1/100,000 in Asian and African/African-American populations to 9.2/ 100,000 in Denmark (Table I).2 The age distribution of testicular cancer is distinct from that for other cancers, with the majority of cases occurring between the ages of 25-35.3 A second, much smaller, peak occurs after 80 years of age.3-5 Testicular cancer incidence varies markedly by race, with blacks and other nonwhite races exhibiting extremely low rates in comparison to white populations.

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“…Mild TDS has been estimated to affect 20% of the world's male population, while 5% of the population is thought to be afflicted with a more severe presentation in which all of the symptoms are present to a significant degree (16).…”

Section: Incidencementioning

confidence: 99%

Is male infertility a forerunner to cancer?

et al. 2010

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Purpose: The frequency of testicular cancer and male infertility has been increasing in the past several decades. This article examines the relationship between male infertility and testicular cancer, concentrating particularly on causal links. Results: Both of these disorders are associated with testicular dysgenesis syndrome and have also been traced to mutations in genes involving DNA repair and tumor suppression, as well as environmental exposure. Conclusion:The identification and examination of these common points of origin supports the integration of testicular cancer screenings into the routine evaluation of infertile men.

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Are Male Reproductive Disorders a Common Entity?

Cited by 79 publications

References 72 publications

An Overview of the Metabolic Functions of Osteocalcin

An Overview of the Metabolic Functions of Osteocalcin

Epidemiology of testicular cancer: An overview

Is male infertility a forerunner to cancer?

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