Are microRNA potential biomarkers in children with idiopathic nephrotic syndrome?

Parvex, Paloma

doi:10.1016/j.ebiom.2018.12.045

Cited by 3 publications

(7 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, the discovery of new noninvasive methods that can identify DN and NDRD has important clinical value. MicroRNAs have become biomarkers of many types of diseases due to their function and varied biological effects [ 17 , 31 , 32 ].…”

Section: Discussionmentioning

confidence: 99%

“…MicroRNA is an endogenous non-coding single-stranded RNA consisting of 21–25 nucleotides [ 17 ]. MicroRNAs can induce the degradation of messenger RNAs and block protein translation.…”

Section: Introductionmentioning

confidence: 99%

“…MicroRNAs can induce the degradation of messenger RNAs and block protein translation. They also play a very important regulatory role in the occurrence and development of kidney disease [ 17 ]. Therefore, the discovery of blood- and urine-specific microRNAs in patients with DN has provided a new direction for identifying diagnostic biomarkers for DN and has enabled the timely screening and disease monitoring of DN [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Urinary sediment microRNAs can be used as potential noninvasive biomarkers for diagnosis, reflecting the severity and prognosis of diabetic nephropathy

et al. 2021

View full text Add to dashboard Cite

Background Patients with both diabetes mellitus (DM) and kidney disease could have diabetic nephropathy (DN) or non-diabetic renal disease (NDRD). IgA nephropathy (IgAN) and membranous nephropathy (MN) are the major types of NDRD. No ideal noninvasive diagnostic model exists for differentiating them. Our study sought to construct diagnostic models for these diseases and to identify noninvasive biomarkers that can reflect the severity and prognosis of DN. Methods The diagnostic models were constructed using logistic regression analysis and were validated in an external cohort by receiver operating characteristic curve analysis method. The associations between these microRNAs and disease severity and prognosis were explored using Pearson correlation analysis, Cox regression, Kaplan–Meier survival curves, and log-rank tests. Results Our diagnostic models showed that miR-95-3p, miR-185-5p, miR-1246, and miR-631 could serve as simple and noninvasive tools to distinguish patients with DM, DN, DM with IgAN, and DM with MN. The areas under the curve of the diagnostic models for the four diseases were 0.995, 0.863, 0.859, and 0.792, respectively. The miR-95-3p level was positively correlated with the estimated glomerular filtration rate (p < 0.001) but was negatively correlated with serum creatinine (p < 0.01), classes of glomerular lesions (p < 0.05), and scores of interstitial and vascular lesions (p < 0.05). However, the miR-631 level was positively correlated with proteinuria (p < 0.001). A low miR-95-3p level and a high miR-631 level increased the risk of progression to end-stage renal disease (p = 0.002, p = 0.011). Conclusions These four microRNAs could be noninvasive tools for distinguishing patients with DN and NDRD. The levels of miR-95-3p and miR-631 could reflect the severity and prognosis of DN.

show abstract

Section: Discussionmentioning

confidence: 99%

“…MicroRNA is an endogenous non-coding single-stranded RNA consisting of 21–25 nucleotides [ 17 ]. MicroRNAs can induce the degradation of messenger RNAs and block protein translation.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Urinary sediment microRNAs can be used as potential noninvasive biomarkers for diagnosis, reflecting the severity and prognosis of diabetic nephropathy

et al. 2021

View full text Add to dashboard Cite

show abstract

“…MicroRNAs (miRNAs/miRs) contain ~19–25 nucleotides and are endogenous non-coding RNAs with gene-regulating functions ( 16 – 19 ). miRNAs are critical in the biological processes of diversified human carcinomas.…”

Section: Introductionmentioning

confidence: 99%

Downregulation of miR‑193a‑3p via targeting cyclin D1 in thyroid cancer

Wen

et al. 2020

Mol Med Rep

View full text Add to dashboard Cite

Thyroid cancer (Tc) is a frequently occurring malignant tumor with a rising steadily incidence. microrna (mirna/mir)-193a-3p is an mirna that is associated with tumors, playing a crucial role in the genesis and progression of various cancers. However, the expression levels of mir-193a-3p and its molecular mechanisms in Tc remain to be elucidated. The present study aimed to probe the expression of miR-193a-3p and its clinical significance in TC, including its underlying molecular mechanisms. Microarray and rna sequencing data gathered from three major databases, specifically Gene expression omnibus (Geo), arrayexpress and The cancer Genome atlas (TcGa) databases, and the relevant data from the literature were used to examine mir-193a-3p expression. Meta-analysis was also conducted to evaluate the association between clinicopathological parameters and mir-193a-3p in 510 Tc and 59 normal samples from the TcGa database. mirWalk 3.0, and the TcGa and Geo databases were used to predict the candidate target genes of mir-193a-3p. Gene ontology, Kyoto encyclopedia of Genes and Genomes and protein-protein interaction network enrichment analyses were conducted by using the predicted candidate target genes to investigate the underlying carcinogenic mechanisms. a dual luciferase assay was performed to validate the targeting regulatory association between the most important hub gene cyclin d1 (ccnd1) and mir-193a-3p. mir-193a-3p expression was considerably downregulated in Tc compared with in the non-cancer controls (P<0.001). The area under the curve of the summary receiver operating characteristic was 0.80. Downregulation of miR-193a-3p was also significantly associated with age, sex and metastasis (P=0.020, 0.044 and 0.048, respectively). Bioinformatics analysis indicated that a low mir-193a-3p expression may augment ccnd1 expression to affect the biological processes of Tc. in addition, ccnd1, as a straightforward target, was validated through a dual luciferase assay. mir-193a-3p and ccnd1 may serve as prognostic biomarkers of Tc. Finally, mir-193a-3p may possess a crucial role in the genesis and progression of Tc by altering the ccnd1 expression.

show abstract

“…Dysregulations of miRNAs have been implicated in pathological events associated with idiopathic NS, hinting at the possibility of miRNAs as promising diagnostic biomarkers and therapeutic targets for NS. For instance, overexpression of miR‐194‐5p facilitated the progression of idiopathic NS via increasing inflammatory responses in glomeruli and podocytes of NS children (Meng et al, 2015), and this miRNA was found to be reduced with disease remission (Parvex, 2019). Alteration of miR expression in podocytes predominantly causes the progression of glomerular diseases, including FSGS (Trionfini & Benigni, 2017).…”

Section: Mirnas In Idiopathic Nsmentioning

confidence: 99%

MicroRNAs in childhood nephrotic syndrome

Dhandapani

Venkatesan

Charmine

2021

Journal Cellular Physiology

View full text Add to dashboard Cite

The discovery of microRNAs (miRNAs) has opened up new avenues of research to understand the molecular basis of a number of diseases. Because of their conservative feature in evolution and important role in the physiological function, microRNAs could be treated as predictors for disease classification and clinical process based on the specific expression. The identification of novel miRNAs and their target genes can be considered as potential targets for novel drugs. Furthermore, currently, the circulatory and urinary exosomal miRNAs are gaining increasing attention as their expression profiles are often associated with specific diseases, and they exhibit great potential as noninvasive or minimally invasive biomarkers for the diagnosis of various diseases. The remarkable stability of these extracellular miRNAs circulating in the blood or excreted in the urine underscored their key importance as biomarkers of certain diseases. There is voluminous literature concerning the role of microRNAs in other diseases, such as cardiovascular diseases, diabetic nephropathy, and so forth. However, little is known about their diagnostic ability for the pediatric nephrotic syndrome (NS). The present review article highlights the recent advances in the role of miRNAs in the pathogenesis and molecular basis of NS with an aim to bring new insights into further research applications for the development of new therapeutic agents for NS.

show abstract

Are microRNA potential biomarkers in children with idiopathic nephrotic syndrome?

Cited by 3 publications

References 8 publications

Urinary sediment microRNAs can be used as potential noninvasive biomarkers for diagnosis, reflecting the severity and prognosis of diabetic nephropathy

Urinary sediment microRNAs can be used as potential noninvasive biomarkers for diagnosis, reflecting the severity and prognosis of diabetic nephropathy

Downregulation of miR‑193a‑3p via targeting cyclin D1 in thyroid cancer

MicroRNAs in childhood nephrotic syndrome

Contact Info

Product

Resources

About