Are mutual interactions between antioxidants the only factors responsible for antagonistic antioxidant effect of their mixtures? Additive and antagonistic antioxidant effects in mixtures of gallic, ferulic and caffeic acids

Olszowy, Małgorzata; Dawidowicz, Andrzej L.; Jóźwik-Dolęba, Małgorzata

doi:10.1007/s00217-019-03255-7

Cited by 32 publications

(22 citation statements)

References 26 publications

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“…In fact, the total antioxidant capacity of a complex mixture is likely to depend on either the antagonistic or synergistic interaction among the different compounds. In particular, the antagonism occurs when the sum of the effects is less than the mathematical sum that would be predicted from individual components [ 52 ]. On the other hand, the combination of antioxidant compounds with complementary action may play an important role to optimize their action.…”

Section: Discussionmentioning

confidence: 99%

Dietary Supplementation of Antioxidant Compounds Prevents Light-Induced Retinal Damage in a Rat Model

et al. 2021

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Light-induced retinal damage (LD) is characterized by the accumulation of reactive oxygen species leading to oxidative stress and photoreceptor cell death. The use of natural antioxidants has emerged as promising approach for the prevention of LD. Among them, lutein and cyanidin-3-glucoside (C3G) have been shown to be particularly effective due to their antioxidant and anti-inflammatory activity. However, less is known about the possible efficacy of combining them in a multicomponent mixture. In a rat model of LD, Western blot analysis, immunohistochemistry and electroretinography were used to demonstrate that lutein and C3G in combination or in a multicomponent mixture can prevent oxidative stress, inflammation, gliotic and apoptotic responses thus protecting photoreceptor cells from death with higher efficacy than each component alone. Combined efficacy on dysfunctional electroretinogram was also demonstrated by ameliorated rod and cone photoreceptor responses. These findings suggest the rationale to formulate multicomponent blends which may optimize the partnering compounds bioactivity and bioavailability.

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Section: Discussionmentioning

confidence: 99%

Dietary Supplementation of Antioxidant Compounds Prevents Light-Induced Retinal Damage in a Rat Model

et al. 2021

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“…Similar to our results, additive or usually light subadditive antioxidant effects were observed when applying end-point ABTS •+ -based decolorization assays; e.g., for different combinations of various phenolics [ 102 ]; a wide set of different antioxidants, such as ascorbic acid, glutathione, quercetin, and uric acid [ 81 ]; human blood plasma combined with flavonoids, incl. quercetin and rutin [ 111 ]; binary and ternary mixtures of gallic, ferulic and caffeic acids [ 112 ]; and flavonoids and ascorbic acid [ 113 ]. Two possible reasons for this subadditivity manifestation were proposed: The formation of non-reactive adducts and regeneration of less active antioxidants by more active antioxidants [ 81 ].…”

Section: Discussionmentioning

confidence: 99%

Flavonoids with Glutathione Antioxidant Synergy: Influence of Free Radicals Inflow

et al. 2020

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This report explores the antioxidant interaction of combinations of flavonoid–glutathione with different ratios. Two different 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid radical (ABTS•+)-based approaches were applied for the elucidation of the antioxidant capacity of the combinations. Despite using the same radical, the two approaches employ different free radical inflow systems: An instant, great excess of radicals in the end-point decolorization assay, and a steady inflow of radicals in the lag-time assay. As expected, the flavonoid–glutathione pairs showed contrasting results in these two approaches. All the examined combinations showed additive or light subadditive antioxidant capacity effects in the decolorization assay. This effect showed slight dilution dependence and did not change when the initial ABTS•+ concentration was two times as high or low. However, in the lag-time assay, different types of interaction were detected, from subadditivity to considerable synergy. Taxifolin–glutathione combinations demonstrated the greatest synergy, at up to 112%; quercetin and rutin, in combination with glutathione, revealed moderate synergy in the 30–70% range; while morin–glutathione appeared to be additive or subadditive. In general, this study demonstrated that, on the one hand, the effect of flavonoid–glutathione combinations depends both on the flavonoid structure and molar ratio; on the other hand, the manifestation of the synergy of the combination strongly depends on the mode of inflow of the free radicals.

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“…In this regard, phenolics (and, particularly, flavonoids [306]) and the It is emblematic that in-vitro and in-vivo studies have almost exclusively been carried out using whole sprouts or, at best, fractionated extracts performed by non-standardized protocols [27,241]. This approach, while offering the possibility of uncovering health benefits and nutraceutical properties of functional foods, gives rise to significant challenges in drawing definitive conclusions due, for example, to variability in the production and preparation of the food matrix, dietary regimens and, importantly, the effects caused by interactions between active nutrients, as in the case of polyphenols where a fine line runs between additive, synergic, and antagonistic effects [303][304][305].…”

Section: Sprouts: a Compelling Case For Drug Discovery?mentioning

confidence: 99%

Sprouts and Microgreens: Trends, Opportunities, and Horizons for Novel Research

et al. 2020

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Sprouts and microgreens have attracted tremendous interest across multiple disciplines in recent years. Here, we critically review the most recent advances to underscore research prospects and niches, and related challenges, not yet addressed or fully pursued. In particular, we report a number of themes that merit special attention as a result of their relevance to plant science, nutrition, health, and zootechnics: (1) species not yet or inadequately investigated, such as wild plants, and fruit tree strains; (2) abiotic and biotic factors, and biostimulants, for elicitation strategies and metabolic engineering; (3) sanitization and processing technologies to obtain high-quality products; (4) digestive fate and impact of bioactive elements, antinutrients, and allergens on human nutrition; (5) experimental challenges to researching health benefits; (6) the opportunity to generate natural product libraries for drug discovery; and (7) sprouts in animal feeding to improve both animal health and the nutritional value of animal products for the human diet. The convergence of different themes involving interdisciplinary competencies advocate fascinating research pursuits, for example, the elicitation of metabolic variants to generate natural product collections for identification and selection of bioactive chemicals with a role as nutraceuticals, key constituents of functional foods, or interactive partners of specific drugs.

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Are mutual interactions between antioxidants the only factors responsible for antagonistic antioxidant effect of their mixtures? Additive and antagonistic antioxidant effects in mixtures of gallic, ferulic and caffeic acids

Cited by 32 publications

References 26 publications

Dietary Supplementation of Antioxidant Compounds Prevents Light-Induced Retinal Damage in a Rat Model

Dietary Supplementation of Antioxidant Compounds Prevents Light-Induced Retinal Damage in a Rat Model

Flavonoids with Glutathione Antioxidant Synergy: Influence of Free Radicals Inflow

Sprouts and Microgreens: Trends, Opportunities, and Horizons for Novel Research

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