Are nestin-positive mesenchymal stromal cells a better source of cells for CNS repair?

Lindsay, Susan L.; Barnett, Susan C.

doi:10.1016/j.neuint.2016.08.001

Cited by 27 publications

(29 citation statements)

References 105 publications

(154 reference statements)

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“…Such variety in the stem cells and OECs in the OM was also proposed following clinical studies of OM grafts transplanted into regions of SCI (Lima et al, ), and the OM has recently been confirmed as a potential source of adult stem cells (Feron, Perry, Girard, & Mackay‐Sim, 2013; Girard et al, ; Lindsay et al, ; Lindsay, Johnstone, McGrath, Mallinson, & Barnett, ; Lindsay & Barnett, ; Nivet et al, ; Stamegna et al, ; Tome, Lindsay, Riddell, & Barnett, 2009). In addition to OECs, human OM biopsies contain up to 5% mesenchymal‐like stromal cells from the LP.…”

Section: Olfactory Cell Characteristics and Their Origins In The Om Omentioning

confidence: 76%

“…In recent years, a stem cell‐like population has been identified in the OE and another one in the LP (Tome et al, 2009). OM‐MSCs have been isolated from the LP and characterized in different laboratories (Delorme et al, ; Feron et al, 2013; Girard et al, ; Lindsay et al, ; Lindsay et al, ; Lindsay & Barnett, ). Transplanted olfactory MSCs differentiated into neurons and stimulated neuroplasticity after lesions in the hippocampus, promoting neurogenesis (Nivet et al, ).…”

Section: Oecs In Spinal Cord Injury (Sci) Repairmentioning

confidence: 99%

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Cell therapy for spinal cord injury with olfactory ensheathing glia cells (OECs)

Gómez

Sanchez

Portela-Lomba

et al. 2018

Glia

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The prospects of achieving regeneration in the central nervous system (CNS) have changed, as most recent findings indicate that several species, including humans, can produce neurons in adulthood. Studies targeting this property may be considered as potential therapeutic strategies to respond to injury or the effects of demyelinating diseases in the CNS. While CNS trauma may interrupt the axonal tracts that connect neurons with their targets, some neurons remain alive, as seen in optic nerve and spinal cord (SC) injuries (SCIs). The devastating consequences of SCIs are due to the immediate and significant disruption of the ascending and descending spinal pathways, which result in varying degrees of motor and sensory impairment. Recent therapeutic studies for SCI have focused on cell transplantation in animal models, using cells capable of inducing axon regeneration like Schwann cells (SchCs), astrocytes, genetically modified fibroblasts and olfactory ensheathing glia cells (OECs). Nevertheless, and despite the improvements in such cell-based therapeutic strategies, there is still little information regarding the mechanisms underlying the success of transplantation and regarding any secondary effects. Therefore, further studies are needed to clarify these issues. In this review, we highlight the properties of OECs that make them suitable to achieve neuroplasticity/neuroregeneration in SCI. OECs can interact with the glial scar, stimulate angiogenesis, axon outgrowth and remyelination, improving functional outcomes following lesion. Furthermore, we present evidence of the utility of cell therapy with OECs to treat SCI, both from animal models and clinical studies performed on SCI patients, providing promising results for future treatments.

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Section: Olfactory Cell Characteristics and Their Origins In The Om Omentioning

confidence: 76%

Section: Oecs In Spinal Cord Injury (Sci) Repairmentioning

confidence: 99%

Cell therapy for spinal cord injury with olfactory ensheathing glia cells (OECs)

Gómez

Sanchez

Portela-Lomba

et al. 2018

Glia

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“…These stem cells could be differentiated in vitro and be beneficial to perform autologous transplantations or disease modeling [42, 43]. …”

Section: Discussionmentioning

confidence: 99%

Isolation of putative stem cells present in human adult olfactory mucosa

et al. 2017

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The olfactory mucosa (OM) has the unique characteristic of performing an almost continuous and lifelong neurogenesis in response to external injuries, due to the presence of olfactory stem cells that guarantee the maintenance of the olfactory function. The easy accessibility of the OM in humans makes these stem cells feasible candidates for the development of regenerative therapies. In this report we present a detailed characterization of a patient-derived OM, together with a description of cell cultures obtained from the OM. In addition, we present a method for the enrichment and isolation of OM stem cells that might be used for future translational studies dealing with neuronal plasticity, neuro-regeneration or disease modeling.

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“…Dermcidin acts as a neural growth factor [95]; retinoic acid is involved in neurobehavioural disorders and plays a role in normal neural development [96] and Cadherin acts as a regulator of neural cell growth [97]. OM-MSCs were identiied as secreting high levels of the chemokine CXCL12 [98] that is known to be important in the promotion of endogenous myelinations [99]. Evidences that OM-MSCs are capable to alter the biological properties of the precursors of OECs and oligodendrocytes and of increasing the myelination of the oligodendrocytes in the CNS [63], in conjunction with the other indings referred, demonstrate the enormous potential of these cells to be applied in regenerative medicine of the nervous system in general and in the PNS in particular.…”

Section: Secretome and Metabolomementioning

confidence: 99%

Olfactory Mucosa Mesenchymal Stem Cells and Biomaterials: A New Combination to Regenerative Therapies after Peripheral Nerve Injury

Alvites¹,

Santos²,

ProençaVarejão³

et al. 2017

Mesenchymal Stem Cells - Isolation, Characterization and Applications

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The peripheral nerve injury after trauma is a common occurrence in both human and veterinary medicine and has severe consequences for the survival and quality of life of the patients. Despite the continuous eforts and the creation of diverse medical and surgical techniques, the harmful efects of this type of injury are far from being overcome. Regenerative medicine has been growing in the scientiic milieu as a new therapeutic approach for diferent situations. Among the cell-based therapies explored, the mesenchymal stem cells are evidenced by their features, versatility and potential applications. The olfactory mucosa mesenchymal stem cells, components of the olfactory system and identiied in the lamina propria, were newly identiied and are still undergoing characterization, appearing as a new promise in the regenerative therapy of several tissues but with special emphasis on the nervous system in general and the peripheral nervous system in particular, for which they appear to have special regenerative aptitude.

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Are nestin-positive mesenchymal stromal cells a better source of cells for CNS repair?

Cited by 27 publications

References 105 publications

Cell therapy for spinal cord injury with olfactory ensheathing glia cells (OECs)

Cell therapy for spinal cord injury with olfactory ensheathing glia cells (OECs)

Isolation of putative stem cells present in human adult olfactory mucosa

Olfactory Mucosa Mesenchymal Stem Cells and Biomaterials: A New Combination to Regenerative Therapies after Peripheral Nerve Injury

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