2018
DOI: 10.1177/1352458518791518
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Are neurofilaments valuable biomarkers for long-term disease prognostication in MS?

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Cited by 11 publications
(8 citation statements)
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“…Several studies highlighted the relevance of sNfL levels to reflect ongoing neuroinflammation as well as neurodegeneration in patients with MS. 8,37 In our cohort, only patients with highly active relapsing-remitting MS disease course were included.…”
Section: Discussionmentioning
confidence: 99%
“…Several studies highlighted the relevance of sNfL levels to reflect ongoing neuroinflammation as well as neurodegeneration in patients with MS. 8,37 In our cohort, only patients with highly active relapsing-remitting MS disease course were included.…”
Section: Discussionmentioning
confidence: 99%
“…Overall, the determination of serum NFL concentration, which does not necessarily require a lumbar puncture but can be now measured in the blood, seems to correlate with many clinical and magnetic tomographic characteristics of MS [96, 104, 105]. A future establishment as a prognostic biomarker in clinical practice is therefore conceivable.…”
Section: Molecular Biomarkers For Ms Prognosismentioning
confidence: 99%
“…Elevated sNfL levels have been shown to reflect acute axonal damage during active inflammation,9 and increasing evidence support the use of sNfL to monitor short-term disease activity, treatment response and disability progression 10. Whether sNfL levels also predict disease progression and neurodegeneration over several years, and even decades, is less clear 6 10–12. Associations between sNfL and long-term disability progression are not consistent,13 14 and although some studies have found higher sNfL levels to be associated with brain13 15 16 and GM atrophy,17–19 studies with extensive follow-up time are few, especially studies considering GM atrophy 17 19.…”
Section: Introductionmentioning
confidence: 99%