Are obesity and rheumatoid arthritis interrelated?

Dar, Lior; Tiosano, Shmuel; Watad, Abdulla; Bragazzi, Nicola Luigi; Zisman, Devi; Comaneshter, Doron; Cohen, Arnon D; Amital, Howard

doi:10.1111/ijcp.13045

Cited by 49 publications

(37 citation statements)

References 39 publications

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“…However, the validity of the diagnoses in the registry was found to be high in previous studies. 1,[8][9][10][11] CRP levels were represented by a mean value of all measured laboratory CRP levels for each participant in blood exams from 2002-2013 (regardless of time and clinical setting within which the test was taken).…”

Section: Patients Selectionmentioning

confidence: 99%

Venous thromboembolism events among RA patients

Mansour

Azrielant

Watad

et al. 2019

MJR

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Background: Rheumatoid arthritis (RA) is associated with an increased risk for venous thromboembolism. However, so far, relatively few and small size-based studies have been conducted. We aimed to investigate the link between RA and venous thromboembolism utilizing a large sample of subjects originating from a large data base. Materials and methods: The study was performed utilizing the medical database of Clalit Health Services, the largest healthcare provider in Israel. We enrolled all patients with RA and age-and gender-matched controls. Chi-square and t-tests were used for univariate analysis and a logistic regression model was used for a multivariate analysis. RA patients were compared to controls regarding the proportion of venous thromboembolic events (defined as deep vein thrombosis, pulmonary embolism or both). Multivariate logistic regression was employed to assess factors associated with thromboembolic events. Results: The study included 11,782 patients with RA and 57,973 age-and gender-matched controls. RA patients had a higher rate of venous thromboembolism events compared with controls (6.92% vs. 3.18%, respectively, p<0.001). RA and mean C-reactive protein levels were found to be independently associated with the proportion of thromboembolic events (OR 2.27 for RA and 1.07 for each 1 mg/dL increment of mean C-reactive protein, respectively). Conclusion: RA and C-reactive protein levels are independently associated with venous thromboembolic events. Physicians should be aware of such findings and have a lower threshold for suspecting detecting such events in patients with RA, mainly those with mean high levels of C-reactive protein.

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Section: Patients Selectionmentioning

confidence: 99%

Venous thromboembolism events among RA patients

Mansour

Azrielant

Watad

et al. 2019

MJR

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“…Study cohorts were matched to patients undergoing THA without RA in a 1:5 ratio by age, sex, and medical comorbidities associated with RA-coronary artery disease, chronic kidney disease, chronic obstructive pulmonary disease, diabetes melli-tus, hyperlipidemia, hypertension, obesity (body mass index > 30 kg/m 2 ), and tobacco use. [18][19][20][21][22][23][24] After the random matching, the query yielded 277,802 patients with (n ¼ 86,507) and without (n ¼ 432,420) RA undergoing primary THA. Matching was successful as the two cohorts were statistically different with respect to age, sex, and medical comorbidities (►Table 1).…”

Section: Methodsmentioning

confidence: 99%

The Effects of Rheumatoid Arthritis on In-Hospital Lengths of Stay, Complications, and Costs following Primary Total Hip Arthroplasty: A Matched-Control Study

Vakharia

Gwam

Luo

et al. 2020

The Journal of Hip Surgery

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Studies investigating the relationship of rheumatoid arthritis (RA) in patients undergoing primary total hip arthroplasty (THA) are limited. Therefore, the purpose of this study was to analyze whether RA patients undergoing primary THA have higher rates of: (1) in-hospital lengths of stay (LOS), (2) medical complications, (3) implant-related complications, and (4) costs of care. A query using an administrative claims database was performed identifying patients who underwent primary THA with RA, whereas patients without RA served as controls. Study group patients were matched to controls in a 1:5 ratio by age, sex, and medical comorbidities. The query yielded 518,927 patients with (n = 86,507) and without (n = 432,420) RA undergoing primary THA. A p-value of less than 0.002 was considered statistically significant. Patients with RA were found to have significantly longer in-hospital LOS (4 vs. 3 days, p < 0.0001). Additionally, RA patients had significantly higher incidence and odds (odds ratio [OR]) of medical (6.39 vs. 1.18%; OR: 5.71, p < 0.0001) and implant-related complications (7.45 vs. 3.35%; OR: 2.32, p < 0.0001) compared with patients without RA. Furthermore, RA patients were found to have significantly higher day of surgery ($12,422.19 vs. $12,103.08, p < 0.0001) and total global 90-day episode of care costs ($16,560.40 vs. $15,167.67, p < 0.0001). This study of 518,927 patients demonstrates patients with RA undergoing primary THA have significantly longer in-hospital LOS, in addition to higher rates of complications and costs. The study is informative as orthopaedists can adequately counsel and educate RA patients of the potential complications which may occur following their procedure.

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“…For every 1000 adults, five will have RA, making it one of the most prevalent chronic inflammatory conditions worldwide [67]. RA etiology is not exactly known due to the synergistic effects of epigenetics [68] and environmental factors (smoking [69,70], obesity [71][72][73], and alcohol consumption [74][75][76]). Autoantibodies such as antibodies to citrullinated protein antigens (ACPAs) or rheumatoid factor (RF) have well-established roles in RA as accurate predictors of disease severity [77][78][79].…”

Section: Rheumatoid Arthritismentioning

confidence: 99%

Molecular Imaging of Inflammatory Disease

et al. 2021

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Inflammatory diseases include a wide variety of highly prevalent conditions with high mortality rates in severe cases ranging from cardiovascular disease, to rheumatoid arthritis, to chronic obstructive pulmonary disease, to graft vs. host disease, to a number of gastrointestinal disorders. Many diseases that are not considered inflammatory per se are associated with varying levels of inflammation. Imaging of the immune system and inflammatory response is of interest as it can give insight into disease progression and severity. Clinical imaging technologies such as computed tomography (CT) and magnetic resonance imaging (MRI) are traditionally limited to the visualization of anatomical information; then, the presence or absence of an inflammatory state must be inferred from the structural abnormalities. Improvement in available contrast agents has made it possible to obtain functional information as well as anatomical. In vivo imaging of inflammation ultimately facilitates an improved accuracy of diagnostics and monitoring of patients to allow for better patient care. Highly specific molecular imaging of inflammatory biomarkers allows for earlier diagnosis to prevent irreversible damage. Advancements in imaging instruments, targeted tracers, and contrast agents represent a rapidly growing area of preclinical research with the hopes of quick translation to the clinic.

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Are obesity and rheumatoid arthritis interrelated?

Abstract: Our findings demonstrate that obesity is significantly associated with RA. This finding underlines the role that obesity plays in inflammation and autoimmune conditions.

Cited by 49 publications

References 39 publications

Venous thromboembolism events among RA patients

Venous thromboembolism events among RA patients

The Effects of Rheumatoid Arthritis on In-Hospital Lengths of Stay, Complications, and Costs following Primary Total Hip Arthroplasty: A Matched-Control Study

Molecular Imaging of Inflammatory Disease

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