Are Participants in Pharmacological and Psychotherapy Treatment Trials for Social Anxiety Disorder Representative of Patients in Real-Life Settings?

Hoertel, Nicolas; Maricourt, Pierre de; Katz, Julien; Doukhan, Raphaël; Lavaud, Pierre; Peyre, Hugo; Limosin, Frédéric

doi:10.1097/jcp.0000000000000204

Cited by 24 publications

(14 citation statements)

References 92 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, the observed bias-anxiety associations were not moderated by age or gender, suggesting that they are further generalizable across these factors. Finally, our findings capture bias-anxiety associations across the full, continuous range of anxiety symptom severity (as well as differences in bias scores between high- and low-anxiety groups), complementing previous work relying only on extreme or diagnosis-based groups which may limit generalizability and dimension-based research (Cuthbert & Insel, 2013; Hoertel et al, 2014). …”

Section: Discussionmentioning

confidence: 51%

Association between attention bias to threat and anxiety symptoms in children and adolescents

et al. 2017

View full text Add to dashboard Cite

These findings indicate associations between threat bias and pediatric anxiety symptoms, and suggest that vigilance to external threats manifests more prominently in symptoms of social anxiety and school phobia, regardless of age and gender. These findings point to the role of attention bias to threat in anxiety, with implications for translational clinical research. The significance of applying standardized methods in multi-site collaborations for overcoming challenges inherent to clinical research is discussed.

show abstract

Section: Discussionmentioning

confidence: 51%

Association between attention bias to threat and anxiety symptoms in children and adolescents

et al. 2017

View full text Add to dashboard Cite

show abstract

“…17–22 The NESARC has been previously used by our group and others to estimate the a priori generalizability of clinical trials of several psychiatric disorders. 4–6,23–29 The NESARC research protocol received approval from the Institutional Review Boards of the US Office of Management and Budget and the US Census Bureau.…”

Section: Methodsmentioning

confidence: 99%

Toward National Estimates of Effectiveness of Treatment for Substance Use

Blanco¹,

Campbell²,

Wall³

et al. 2017

J. Clin. Psychiatry

View full text Add to dashboard Cite

Objective To estimate how results would have varied if a substance abuse clinical trial had been conducted with nationally representative adults with substance use and with representative adults receiving substance use treatment. Method Results were analyzed from a multisite clinical trial comparing the effectiveness of the Therapeutic Education System (TES) to treatment-as-usual for outpatient addiction treatment (n=507). Abstinence in the last four weeks of treatment was the primary outcome. The general population sample and general population treated samples were derived from Wave 1 of the National Epidemiological Survey on Alcohol and Related Conditions (NESARC) (n=43,093). Propensity scores provided a standardized measure of the difference between clinical trial participants and the two NESARC samples. The clinical trial was reanalyzed by reweighting the sample with propensity scores derived for the two samples to obtain generalizable estimates of treatment effects. Results Prior to reweighting, the Odds Ratio (OR) of response to TES versus treatment-as-usual in the trial was 1.62 (95% CI=1.12–2.35). After reweighting the sample to be representative of the two groups, ORs were 1.33 (95% CI=0.34–5.26) for the representative sample with any substance use and 1.64 (95% CI=0.82–3.27) for the representative treated sample. Conclusion Applying propensity score weighting to clinical trial results provides a method for estimating the population generalizability of clinical trial findings that relies on effect moderators observed in the study sample and population. Broader confidence intervals in the reweighted samples do not necessarily indicate lack of efficacy of TES, but rather greater uncertainty concerning effectiveness in general population samples.

show abstract

“…Social anxiety disorder (SAD) (formerly called social phobia) is one of the most common anxiety disorders with up to 13% of people in the United States experiencing this disorder at some point during their lives (Ruscio et al, 2008). Individuals with SAD often present with substantial comorbid psychopathology, includ-Abbreviations: ABIC, adjusted BIC; AIC, Akaike's Information Criterion; BIC, Bayesian Information Criterion; LCA, latent class analysis; LRT, likelihood ratio test; NCS, National Comorbidity Survey; SAD, social anxiety disorder; SE, standard error ing major depressive disorder and substance use disorders (Blanco et al, 2011;Grant et al, 2005;Hoertel et al, 2014;Magee, Eaton, Wittchen, McGonagle, & Kessler, 1996;Schneier et al, 2010;Stein, Torgrud, & Walker, 2000) and constitute a heterogeneous group of patients according to the type of feared social situations, comorbid mental disorders, and quality of life (Bögels et al, 2010;Ruscio et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Latent class analysis of the feared situations of social anxiety disorder: A population-based study

et al. 2016

Self Cite

View full text Add to dashboard Cite

show abstract

Are Participants in Pharmacological and Psychotherapy Treatment Trials for Social Anxiety Disorder Representative of Patients in Real-Life Settings?

Cited by 24 publications

References 92 publications

Association between attention bias to threat and anxiety symptoms in children and adolescents

Association between attention bias to threat and anxiety symptoms in children and adolescents

Toward National Estimates of Effectiveness of Treatment for Substance Use

Latent class analysis of the feared situations of social anxiety disorder: A population-based study

Contact Info

Product

Resources

About