Are Patients With Fibromyalgia in a Prothrombotic State?

Molina, Francisco; Moral, Marı́a Luisa Del; Rubia, Mercedes La; Blanco, Santos; Carmona, Rafael Marfil; Rus, Alma

doi:10.1177/1099800418824716

Cited by 15 publications

(20 citation statements)

References 18 publications

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“…In this regard, it has been reported that MPV is not as specific a marker of platelet activity as PDW because it increases during simple platelet swelling [22]. Moreover, other authors reported finding an inverse relationship between MPV and platelet count [23], as we observed in our previous study [7]. The increase in MPV values due to ROO consumption in the present study would not be negative, since it approximates values of patients with FM to those of healthy subjects [7].…”

Section: Discussionsupporting

confidence: 62%

“…In a previous study, we found altered levels of thrombosis-related parameters, including higher fibrinogen levels, PDW values and RBC counts, and lower MPV values in patients with FM in comparison to controls [7]. Results of the present study show that olive oil may return altered levels compared to those of the healthy controls (data from healthy subjects can be consulted at Molina et al, 2019 [7]). Curiously, although increased MPV values may be considered as a cardiovascular risk factor, our previous data showed significantly lower MPV values in FM patients that may be in a prothrombotic state when compared to healthy subjects [7].…”

Section: Discussionsupporting

confidence: 54%

“…Results of the present study show that olive oil may return altered levels compared to those of the healthy controls (data from healthy subjects can be consulted at Molina et al, 2019 [7]). Curiously, although increased MPV values may be considered as a cardiovascular risk factor, our previous data showed significantly lower MPV values in FM patients that may be in a prothrombotic state when compared to healthy subjects [7]. In this regard, it has been reported that MPV is not as specific a marker of platelet activity as PDW because it increases during simple platelet swelling [22].…”

Section: Discussionmentioning

confidence: 53%

“…PDW and MPV estimate platelet function and their increased values may be considered risk factors for cardiovascular disease [21]. In a previous study, we found altered levels of thrombosis-related parameters, including higher fibrinogen levels, PDW values and RBC counts, and lower MPV values in patients with FM in comparison to controls [7]. Results of the present study show that olive oil may return altered levels compared to those of the healthy controls (data from healthy subjects can be consulted at Molina et al, 2019 [7]).…”

Section: Discussionmentioning

confidence: 87%

“…We have recently reported a prothrombotic state in patients diagnosed with FM, reflected by altered levels of thrombosis-related parameters, such as fibrinogen; prothrombin time; red blood cell (RBC); and platelet counts, platelet distribution width (PDW), mean platelet volume (MPV) and platelet-to-lymphocyte ratio (PLR) [7]. This prothrombotic state may increase the risk for cardiovascular disease in patients with FM.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Olive Oil Consumption on Cardiovascular Risk Factors in Patients with Fibromyalgia

et al. 2020

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We have recently reported that patients with fibromyalgia (FM) may be at increased risk for cardiovascular disease. Olive oil reportedly has cardioprotective effects. We examined the influence of olive oil consumption on cardiovascular risk factors in FM. This preliminary study was performed on blood samples of women with FM who consumed 50 mL of organic olive oil daily for 3 weeks. Patients were randomized into two groups: 15 women ingested extra virgin olive oil (EVOO) and 15 refined olive oil (ROO). Cardiovascular risk markers were measured at baseline (pre measure) and after consumption of olive oil (post measure). Red blood cell count and erythrocyte sedimentation rate (ESR; both p < 0.05) declined significantly post-treatment in the EVOO group. Consumption of ROO increased mean platelet volume and reduced platelet distribution width (PDW), neutrophil-to-lymphocyte ratio, ESR and fibrinogen (all p < 0.05). Significant differences were found in pre–post change between the EVOO and ROO groups for cortisol and PDW (both p < 0.05). Our results have shown that consumption of olive oil may have antithrombotic and antiinflammatory properties in patients with FM, thereby improving a number of cardiovascular risk markers. Both EVOO and ROO may be useful as adjuvants for the prevention and/or treatment of cardiovascular disorders in these patients.

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Section: Discussionsupporting

confidence: 62%

Section: Discussionsupporting

confidence: 54%

Section: Discussionmentioning

confidence: 53%

Section: Discussionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

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Effects of Olive Oil Consumption on Cardiovascular Risk Factors in Patients with Fibromyalgia

et al. 2020

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Proteomics in Patients with Fibromyalgia Syndrome: A Systematic Review of Observational Studies

Gkouvi,

Tsiogkas,

Bogdanos

et al. 2024

Curr Pain Headache Rep

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Purpose of Review Fibromyalgia syndrome (FMS) is a disease of unknown pathophysiology, with the diagnosis being based on a set of clinical criteria. Proteomic analysis can provide significant biological information for the pathophysiology of the disease but may also reveal biomarkers for diagnosis or therapeutic targets. The present systematic review aims to synthesize the evidence regarding the proteome of adult patients with FMS using data from observational studies. Recent Findings An extensive literature search was conducted in MEDLINE/PubMed, CENTRAL, and clinicaltrials.gov from inception until November 2022. The study protocol was published in OSF. Two independent reviewers evaluated the studies and extracted data. The quality of studies was assessed using the modified Newcastle–Ottawa scale adjusted for proteomic research. Ten studies fulfilled the protocol criteria, identifying 3328 proteins, 145 of which were differentially expressed among patients with FMS against controls. The proteins were identified in plasma, serum, cerebrospinal fluid, and saliva samples. The control groups included healthy individuals and patients with pain (inflammatory and non-inflammatory). Summary The most important proteins identified involved transferrin, α-, β-, and γ-fibrinogen chains, profilin-1, transaldolase, PGAM1, apolipoprotein-C3, complement C4A and C1QC, immunoglobin parts, and acute phase reactants. Weak correlations were observed between proteins and pain sensation, or quality of life scales, apart from the association of transferrin and a2-macroglobulin with moderate-to-severe pain sensation. The quality of included studies was moderate-to-good. FMS appears to be related to protein dysregulation in the complement and coagulation cascades and the metabolism of iron. Several proteins may be dysregulated due to the excessive oxidative stress response.

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Patients with fibromyalgia have increased risk of 90-day postoperative adverse events following arthroscopic rotator cuff repair

Rancu,

Katsnelson,

Sanchez

et al. 2024

JSES International

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Are Patients With Fibromyalgia in a Prothrombotic State?

Cited by 15 publications

References 18 publications

Effects of Olive Oil Consumption on Cardiovascular Risk Factors in Patients with Fibromyalgia

Effects of Olive Oil Consumption on Cardiovascular Risk Factors in Patients with Fibromyalgia

Proteomics in Patients with Fibromyalgia Syndrome: A Systematic Review of Observational Studies

Patients with fibromyalgia have increased risk of 90-day postoperative adverse events following arthroscopic rotator cuff repair

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