Are people with uncontrolled diabetes mellitus at high risk of reinfections with COVID-19?

Pal, Rimesh; Banerjee, Mainak

doi:10.1016/j.pcd.2020.08.002

Cited by 43 publications

(45 citation statements)

References 36 publications

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“…Closer clinical surveillance and prescription of prophylactic heparin could reduce the incidence of severe cases of TVE in patients at greatest risk. 18 Moreover, treatment of patients during initial admission with intravenous fluids, glucocorticoids and anticoagulants may cause worsening of chronic diseases such as heart failure or diabetes and end up causing readmissions. In addition, uncontrolled diabetic patients may present impaired adaptive immune response due to an inadequate CD4+ T-cell response.…”

Section: Description Of the Cause For Admission At Initial Admission mentioning

confidence: 99%

Hospital Readmissions of Discharged Patients with COVID-19

Parra¹,

Cantero²,

Morrás³

et al. 2020

IJGM

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Objective: To analyse the rate of occurrence and the clinical variables associated with readmission of patients who had previously been discharged after admission for COVID-19. Setting: University hospital in Madrid (Spain). Participants: Sixty-one patients (74% male) who presented COVID-19 were readmitted during the 3 weeks after discharge from hospital. Interventions: Nested case-control study paired (1:1 ratio) by age, sex and period of admission. Outcome Measures: Rate of readmission rate of patients discharged after suffering COVID-19 and identification of the clinical variables associated with it. Results: Out of 1368 patients who were discharged during the study period, 61 patients (4.4%) were readmitted. Immunocompromised patients (N=10.2%) were at increased risk for readmission (p=0.04). There was also a trend towards a higher probability of readmission in hypertensive patients (p=0.07). Cases had had a shorter hospital stay and a higher prevalence of fever during the 48 hours prior to discharge. There were no significant differences in oxygen levels measured at admission and discharge by pulse oximetry intra-subject or between the groups. Neutrophil-to-lymphocyte ratio at hospital admission tended to be higher in cases than in controls (p=0.06). Neither glucocorticoids nor anticoagulants prescribed at hospital discharge were associated with a lower readmission rate. Patients who were readmitted due to a thrombotic event (8 patients, 13.1%) presented a higher level of D-dimer at discharge of initial admission. Conclusion: The rate of readmission after discharge from hospital for COVID-19 was low. Immunocompromised patients and those presenting with fever during the 48 hours prior to discharge were at greater risk of readmission to hospital.

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Section: Description Of the Cause For Admission At Initial Admission mentioning

confidence: 99%

Hospital Readmissions of Discharged Patients with COVID-19

Parra¹,

Cantero²,

Morrás³

et al. 2020

IJGM

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“…Diabetes mellitus (DM) is associated with a high risk of severe disease, acute respiratory distress syndrome, intensive care unit admissions, and eventual mortality from the novel coronavirus disease (COVID-19) [ 1 , 2 ]. It has also been hypothesized that DM might increase the chances of reinfections with COVID-19 [ 3 ]. In line with this hypothesis, several cases of clinical recurrences of COVID-19 and/or positive real time-polymerase chain reaction (RT-PCR) re-positives have been reported in patients with DM [ [4] , [5] , [6] , [7] , [8] ].…”

Section: Introductionmentioning

confidence: 99%

Impaired anti-SARS-CoV-2 antibody response in non-severe COVID-19 patients with diabetes mellitus: A preliminary report

Pal

Sachdeva

Mukherjee

et al. 2021

Diabetes & Metabolic Syndrome: Clinical Research & Revi

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Background and aims Patients with diabetes mellitus (DM) often demonstrate impaired antibody response to influenza/hepatitis B vaccines. Hence, we compared anti-SARS-CoV-2 antibody response in non-severe COVID-19 patients with and without type 2 diabetes mellitus (T2DM). Methods Records of non-severe COVID-19 patients admitted at our institution between April 10, 2020 and May 20, 2020 were retrieved. Qualitative detection of total (IgG + IgM) anti-SARS-CoV-2 antibody was performed using electrochemiluminescence immunoassay in plasma samples collected at least 14 days post-polymerase chain reaction (PCR) confirmation of diagnosis. Results Thirty-one non-severe COVID-19 patients were included. Nine patients (29%) had T2DM with mean HbA 1c at admission of 8.3 ± 1.0%. Anti-SARS-CoV-2 antibody was estimated at a median of 16 (14–17) days post-PCR confirmation of COVID-19 diagnosis. Only three patients (10%) were seronegative, and all had T2DM. Patients with T2DM were more likely to have non-detectable anti-SARS-CoV-2 antibodies than those without DM ( p = 0.019). Conclusions COVID-19 patients with T2DM may not undergo seroconversion even after two weeks of diagnosis. Impaired seroconversion could theoretically increase the risk of reinfections in patients with DM. However, the finding requires validation in large-scale studies involving serial estimations of anti-SARS-CoV-2 antibodies in patients with and without DM.

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“…Patients with diabetes recovering from COVID-19, who experienced the chronic hyperglycemic state and persistent inflammatory states, are at higher risk of COVID-19 reinfection and the occurrence and progression of DM complications. 13 There is a compelling need for this vulnerable population to reduce this risk through good blood sugar control during their isolation. However, ideal blood sugar levels cannot be maintained solely by anti-diabetic medications; 14 good self-management behaviors play a crucial role in DM treatment—especially for those with type 2 diabetes mellitus (T2DM).…”

Section: Introductionmentioning

confidence: 99%

Barriers to Self-Management of Type 2 Diabetes During COVID-19 Medical Isolation: A Qualitative Study

Shi¹,

Zhu²,

Li³

et al. 2020

DMSO

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Purpose: Diabetes self-management behaviors are necessary to obtain optimum glycemic control, reduce the risk of complications, and improve health outcomes. The COVID-19 pandemic imposes an additional struggle for self-management by diabetes patients. Although previous studies have reported socio-demographic, behavioral, psychological, and cultural barriers to diabetes self-management, little is known about perceived barriers to diabetes self-management among patients during isolation following their recovery from COVID-19. The purpose of this study was to explore perceived barriers among type 2 diabetes patients during isolation following their recovery from COVID-19. Patients and Methods: A qualitative, exploratory, and descriptive research design was utilized. Semi-structured telephonic interviews were conducted with 12 patients with diabetes who had been discharged from one COVID-19 designated hospital and underwent isolation in the designated facilities in Wuhan City, Hubei Province, China. Data were analyzed using Colaizzi's seven steps. Results: Barriers to diabetes self-management identified by patients with diabetes during isolation were categorized into five major themes: inadequate knowledge and behavioral beliefs, shortage of resources, suffering from health problems, negative emotions, and lack of support. Conclusion: Perceived barriers to diabetes self-management described by diabetes patients indicated a lack of environmental resources and support strategies to meet their needs. Efforts to remove barriers are important in assisting patients with diabetes to improve their quality of life and health outcomes.

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Are people with uncontrolled diabetes mellitus at high risk of reinfections with COVID-19?

Cited by 43 publications

References 36 publications

<p>Hospital Readmissions of Discharged Patients with COVID-19</p>

<p>Hospital Readmissions of Discharged Patients with COVID-19</p>

Impaired anti-SARS-CoV-2 antibody response in non-severe COVID-19 patients with diabetes mellitus: A preliminary report

<p>Barriers to Self-Management of Type 2 Diabetes During COVID-19 Medical Isolation: A Qualitative Study</p>

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